super ace in gcash By Michelle Marchante, Miami Herald (TNS) MIAMI — As her students finished their online exam, Arlet Lara got up to make a cafe con leche . Her 16-year-old son found her on the kitchen floor. First, he called Dad in a panic. Then 911. “I had a stroke and my life made a 180-degree turn,” Lara told the Miami Herald, recalling the medical scare she experienced in May 2020 in the early months of the COVID pandemic. “The stroke affected my left side of the body,” the North Miami woman and former high school math teacher said. Lara, an avid runner and gym goer, couldn’t even walk. “It was hard,” the 50-year-old mom said. After years of rehabilitation therapy and a foot surgery, Lara can walk again. But she still struggles with moving. This summer, she became the first patient in South Florida to get an implant of a new and only FDA-approved nerve stimulation device designed to help ischemic stroke survivors regain movement in their arms and hands. This first procedure was at Jackson Memorial Hospital in Miami. Lara’s rehab was at at the Christine E. Lynn Rehabilitation Center for The Miami Project to Cure Paralysis, part of a partnership between Jackson Health System and UHealth. Every year, thousands in the United States have a stroke , with one occurring every 40 seconds, according to the U.S. Centers for Disease Control and Prevention. The majority of strokes are ischemic, often caused by blood clots that obstruct blood flow to the brain. For survivors, most of whom are left with some level of disability, the Vivistim Paired VNS System, the device implanted in Lara’s chest, could be a game changer in recovery, said Dr. Robert Starke, a UHealth neurosurgeon and interventional neuroradiologist. He also serves as co-director of endovascular neurosurgery at Jackson Memorial Hospital, part of Miami-Dade’s public hospital system. Arlet Lara, the first patient in South Florida to get an FDA-approved nerve stimulation implant, right, runs into her rehabilitation neurology physician Dr. Gemayaret Alvarez, before her physical therapy appointment on Monday, Sept. 9, 2024, at Lynn Rehabilitation Center at Jackson Memorial Hospital. The implant is designed to help stroke survivors regain function in their arms. (Alie Skowronski/Miami Herald/TNS) Arlet Lara, the first patient in South Florida to get an FDA-approved nerve stimulation implant designed to help stroke survivors regain function in their arms, goes through exercises while her therapist activates the device during her physical therapy appointment on Monday, Sept. 9, 2024, at Lynn Rehabilitation Center at Jackson Memorial Hospital. The activation works as positive reinforcement to her muscles when she completes the exercise correctly. (Alie Skowronski/Miami Herald/TNS) Arlet Lara, the first patient in South Florida to get an FDA-approved nerve stimulation implant, does an exercise while Neil Batungbakal, rehabilitation therapist, activates the implant with the black trigger during her physical therapy appointment on Monday, Sept. 9, 2024, at Lynn Rehabilitation Center at Jackson Memorial Hospital. The implant is designed to help stroke survivors regain function in their arms. The activation works as positive reinforcement to her muscles when she completes the exercise correctly. (Alie Skowronski/Miami Herald/TNS) Arlet Lara, the first patient in South Florida to get an FDA- approved nerve stimulation implant, does an exercise while Neil Batungbakal, rehabilitation therapist, activates the implant with the black trigger during her physical therapy appointment on Monday, Sept. 9, 2024, at Lynn Rehabilitation Center at Jackson Memorial Hospital. Arlet Lara, the first patient in South Florida to get an FDA-approved nerve stimulation implant, right, runs into her rehabilitation neurology physician Dr. Gemayaret Alvarez, before her physical therapy appointment on Monday, Sept. 9, 2024, at Lynn Rehabilitation Center at Jackson Memorial Hospital. The implant is designed to help stroke survivors regain function in their arms. (Alie Skowronski/Miami Herald/TNS) The Vivistim Paired VNS System is a small pacemaker-like device implanted in the upper chest and neck area. Patients can go home the same day. The U.S. Food and Drug Administration approved the stroke rehabilitation system in 2021 to be used alongside post-ischemic stroke rehabilitation therapy to treat moderate to severe mobility issues in hands and arms. Lara’s occupational therapist can activate the device during rehabilitation sessions to electrically stimulate the vagus nerve, which runs from the brain down to the abdomen and regulates various parts of the body’s nervous system. The electrical stimulation rewires the brain to improve a stroke survivor’s ability to move their arms and hands. Lara also has a magnet she can use to activate the device when she wants to practice at home. Her therapy consists of repetitive tasks, including coloring, pinching cubes and grabbing and releasing cylindrical shapes. After several weeks of rehabilitation therapy with the device, Lara has seen improvement. “Little by little, I’m noticing that my hand is getting stronger. I am already able to brush my teeth with the left hand,” she told the Miami Herald in September. Since then, Lara has finished the initial six-week Vivitism therapy program, and is continuing to use the device in her rehabilitation therapy. She continues to improve and can now eat better with her left hand and can brush her hair with less difficulty, according to her occupational therapist, Neil Batungbakal. Lara learned about the device through an online group for stroke survivors and contacted the company to inquire. She then connected them with her Jackson medical team. Now a year later, the device is available to Jackson patients. So far, four patients have received the implant at Jackson. Starke sees the device as an opportunity to help bring survivors one step closer to regaining full mobility. Strokes are a leading cause of disability worldwide. While most stroke survivors can usually recover some function through treatment and rehabilitation, they tend to hit a “major plateau” after the first six months of recovery, he said. Vivistim, when paired with rehabilitation therapy, could change that. Jackson Health said results of a clinical trial published in the peer-reviewed medical journal The Lancet in 2021 showed that the device, “when paired with high-repetition, task-specific occupational or physical therapy, helps generate two to three times more hand and arm function for stroke survivors than rehabilitation therapy alone.” The device has even shown to benefit patients 20 years from their original stroke, according to Starke. “So now a lot of these patients that had strokes 10-15 years ago that thought that they would never be able to use their arm in any sort of real functional way are now able to have a real meaningful function, which is pretty tremendous,” Starke said. Vivistim’s vagus-nerve stimulation technology was developed by researchers at the University of Texas at Dallas’ Texas Biomedical Device Center and is being sold commercially by Austin-based MicroTransponder, a company started by university graduates. Similar devices are used to treat epilepsy and depression . For Lara, the device is a new tool to help her recovery journey. “Everything becomes a challenge so we are working with small things every day because I want to get back as many functions as possible,” Lara said. Patients interested in Vivistim should speak with their doctor to check their eligibility. The FDA said patients should make sure to discuss any prior medical history, including concurrent forms of brain stimulation, current diathermy treatment, previous brain surgery, depression, respiratory diseases and disorders such as asthma, and cardiac abnormalities. “Adverse events included but were not limited to dysphonia (difficulty speaking), bruising, falling, general hoarseness, general pain, hoarseness after surgery, low mood, muscle pain, fracture, headache, rash, dizziness, throat irritation, urinary tract infection and fatigue,” the FDA said. MicroTransponder says the device is “covered by Medicare, Medicaid, and private insurance with prior authorization on a case-by-case basis.” To learn more about the device, visit vivistim.com. ©2024 Miami Herald. Visit at miamiherald.com. Distributed by Tribune Content Agency, LLC.Quarterbacks in spotlight when No. 6 Miami visits Syracuse

He is not yet in power but President-elect Donald Trump rattled much of the world with an off-hours warning of stiff tariffs on close allies and China -- a loud hint that Trump-style government by social media post is coming back. With word of these levies against goods imported from Mexico, Canada and China, Trump sent auto industry stocks plummeting, raised fears for global supply chains and unnerved the world's major economies. For Washington-watchers with memories of the Republican's first term, the impromptu policy volley on Monday evening foreshadowed a second term of startling announcements of all manner, fired off at all hours of the day from his smartphone. "Donald Trump is never going to change much of anything," said Larry Sabato, a leading US political scientist and director of the University of Virginia's Center for Politics. "You can expect in the second term pretty much what he showed us about himself and his methods in the first term. Social media announcements of policy, hirings and firings will continue." The first of Trump's tariff announcements -- a 25 percent levy on everything coming in from Mexico and Canada -- came amid an angry rebuke of lax border security at 6:45 pm on Truth Social, Trump's own platform. The United States is bound by agreements on the movement of goods and services brokered by Trump in a free trade treaty with both nations during his first term. But Trump warned that the new levy would "remain in effect until such time as Drugs, in particular Fentanyl, and all Illegal Aliens stop this Invasion of our Country" -- sowing panic from Ottawa to Mexico City. Seconds later, another message from the incoming commander-in-chief turned the focus on Chinese imports, which he said would be hit with "an additional 10% Tariff, above any additional Tariffs." The consequences were immediate. Almost every major US automaker operates plants in Mexico, and shares in General Motors and Stellantis -- which produce pickup trucks in America's southern neighbor -- plummeted. Canada, China and Mexico protested, while Germany called on its European partners to prepare for Trump to impose hefty tariffs on their exports and stick together to combat such measures. The tumult recalls Trump's first term, when journalists, business leaders and politicians at home and abroad would scan their phones for the latest pronouncements, often long after they had left the office or over breakfast. During his first four years in the Oval Office, the tweet -- in those days his newsy posts were almost exclusively limited to Twitter, now known as X -- became the quasi-official gazette for administration policy. The public learned of the president-elect's 2020 Covid-19 diagnosis via an early-hours post, and when Iranian Revolutionary Guards commander Qasem Soleimani was assassinated on Trump's order, the Republican confirmed the kill by tweeting a US flag. The public and media learned of numerous other decisions big and small by the same source, from the introduction of customs duties to the dismissal of cabinet secretaries. It is not a communication method that has been favored by any previous US administration and runs counter to the policies and practices of most governments around the world. Throughout his third White House campaign, and with every twist and turn in his various entanglements with the justice system, Trump has poured his heart out on Truth Social, an app he turned to during his 20-month ban from Twitter. In recent days, the mercurial Republican has even named his attorney general secretaries of justice and health via announcements on the network. "He sees social media as a tool to shape and direct the national conversation and will do so again," said political scientist Julian Zelizer, a Princeton University professor. cjc/ft/dw/bjt

Manitoba continues to have the highest rates of child poverty in Canada, according to findings released in the 2024 Manitoba Child and Family Poverty Report Tuesday. The report highlights an increase in child and family poverty in the province, with Winnipeg Centre showing the highest rate of child poverty among urban federal ridings. Data from the 2022 tax filers reveals a sharp rise in poverty rates, particularly among children under 18 and under 6. The report’s findings also show that the percentage of children living in food-insecure households in Manitoba rose to 32.6% in 2023 from 25.7% in 2022. “As the provincial government is getting ready to roll out its poverty reduction strategy, we hope they will engage with us on the findings and the proposed solutions in this report,” said Dr. Sid Frankel, senior scholar at the University of Manitoba and member of the Campaign 2000 national steering committee. “Our recommendations are not a comprehensive list but offer some small, intermediate and large actions the province can commit to now, and then again, of course, at budget time.” Experts warn of the serious consequences of food insecurity for children and adolescents, who are more likely to face health issues, including increased hospital visits and mental health challenges. Dr. Natalie Riediger, Associate Professor at the University of Manitoba, noted, “Children and adolescents living in food insecure households are more likely to be hospitalized, visit the emergency room, require day surgery, and access health services for mental or substance use disorders.” Local organizations also see the issue worsening. “Every day, we see the need growing in our community and the desperation that unmet needs bring about,” said Mary Burton of Zoongizi Ode. “There have been some positive movements from the government but when the situation has been allowed to get this bad, we need much more.” The Christmas Cheer Board has reported a 27% increase in requests for help since 2021, with more than 21,000 requests expected this year. “We have even moved away from providing the traditional Christmas dinner because people are having so much trouble just meeting basic needs,” said Shawna Bell, executive director of the Christmas Cheer Board. Meaghan Erbus from Harvest Manitoba echoed these concerns, “The stats we provided for this report are just the tip of the iceberg. Our upcoming Voices report, to be released in December, has stories that prove resiliency but also heartbreak.” The report also highlights the deepening income inequality in Manitoba, where the richest 10% earn 22.6 times more than the lowest 10%. “It is clear that income inequality is alive and well in Manitoba,” said Kate Kehler of the Social Planning Council of Winnipeg. “Inequality is greater in Manitoba than in Canada as a whole. We need an equity lens on taxes at all three levels of government.” The report calls for immediate and comprehensive action to address these issues, with a particular focus on addressing the root causes of poverty, improving access to basic needs, and ensuring that education and social systems work for all Manitobans. Dr. Sid Frankel said, “Education got us into this mess and education will get us out of it,” quoting the late Murray Sinclair. “We know there are better ways to educate and care for our children and we need the commitment to implement them.” As the province prepares to launch its poverty reduction strategy, advocates said the government needs to take these recommendations seriously and prioritize urgent action to reduce child and family poverty.Israel strikes kill 52 in Lebanon as Hezbollah targets south Israel

Sherritt International Co. (OTCMKTS:SHERF) Sees Large Decline in Short Interest

DETROIT — Fifty years later, a man who grew up in suburban Detroit tried to return a very overdue baseball book to his boyhood library. The answer: You can keep it — and no fine. Chuck Hildebrandt, 63, of Chicago said he visited the public library in Warren while in town for Thanksgiving, carrying a book titled "Baseball's Zaniest Stars." He borrowed it in 1974 as a 13-year-old "baseball nut" but never returned it. Chuck Hildebrandt of Chicago holds the book "Baseball's Zaniest Stars," which was due Dec. 4, 1974, at the Warren, Mich., library, on Dec. 10. "When you're moving with a bunch of books, you're not examining every book. You throw them in a box and go," said Hildebrandt, who lived in many cities. "But five or six years ago, I was going through the bookshelf and there was a Dewey decimal library number on the book. 'What is this?'" Inside the book was a slip of paper indicating it was due back at the Warren library on Dec. 4, 1974. Hildebrandt told The Associated Press he decided to keep the book until 2024 — the 50th anniversary — and then try to return it. He figured the library might want to publicize the long overdue exchange. Chuck Hildebrandt of Chicago shows the library slip in the overdue book "Baseball's Zaniest Stars" on Dec. 10. He said he recently met library director Oksana Urban, who listened to his pitch. Hildebrandt said he hasn't heard anything since then, though Urban told the Detroit Free Press that all is forgiven. "Some people never come back to face the music," she said of patrons with overdue books. "But there was really no music to face because he and the book were erased from our system." So "Baseball's Zaniest Stars" is back on Hildebrandt's shelf. In return, he's now trying to raise $4,564 for Reading is Fundamental , a nonprofit literacy group. The amount roughly represents a 50-year overdue library fine. Hildebrandt seeded the effort with $457. The Major League Baseball draft is unique among professional sports drafts. The 30 organizations pick teenagers and college students who will not join their big league clubs for years—if ever. These athletes will spend that time honing their craft in the minor leagues, where long bus rides and minuscule paychecks are the norm. A few will move quickly up the ranks, seizing playing time opportunities to advance their careers and making their names known to scouts, fans, and other observers around the country. Some of the best will become MLB stars, but there's minimal correlation to draft position. Four of the players on this list were picked after hundreds of other diamond darlings, and only two were #1 overall selections. There's also more than a handful who didn't do much for the teams that drafted them, including superstars such as Nolan Ryan, Ozzie Smith, and Randy Johnson. Each of these players was traded before they evolved into Hall of Famers. Still, calling the draft a "crapshoot" might be going too far. College players are " slightly more likely " than high schoolers to reach the revered stadiums of the majors, and third-rounders have a better chance than fifth-rounders, for example, though the margins are slim, as Vice reported. Teams not only make picks based on years-in-advance projections but also whether they can sign players, a step that must be completed before those youngsters begin playing professionally. To see how clubs have fared since the inaugural draft in 1965, ATS.io compiled a list of the best draft pick by each franchise using data from Baseball Reference . The players were ranked using career wins above replacement , so not one recent choice was named. The amazing Mike Trout, a 32-year-old selected in 2009, is the youngest player. Unsigned picks were not considered, and players who were traded as picks were credited to their acquiring teams. Data is as of June 5, 2024. - Draft: 11th overall pick in 2006 - Position: Pitcher - Games played: 457 - Career stats: 214 wins, 3.15 earned run average, 1.08 walks plus hits per inning - College/HS: University of Missouri (Columbia, Mo.) - Wins above replacement: 75.0 - Draft: 1st overall pick in 1990 - Position: Shortstop - Games played: 2,499 - Career stats: 468 home runs, .303 batting average, .930 on-base plus slugging - College/HS: The Bolles School (Jacksonville, Fla.) - Wins above replacement: 85.3 - Draft: 48th overall pick in 1978 - Position: Third baseman - Games played: 3,001 - Career stats: 431 home runs, .276 batting average, .788 on-base plus slugging - College/HS: Aberdeen HS (Aberdeen, Md.) - Wins above replacement: 95.9 - Draft: 19th overall pick in 1983 - Position: Pitcher - Games played: 709 - Career stats: 354 wins, 3.12 earned run average, 1.17 walks plus hits per inning - College/HS: University of Texas at Austin (Austin, Texas) - Wins above replacement: 139.2 - Draft: 31st overall pick in 1984 - Position: Pitcher - Games played: 744 - Career stats: 355 wins, 3.16 earned run average, 1.14 walks plus hits per inning - College/HS: Valley HS (Las Vegas, Nev.) - Wins above replacement: 106.6 - Draft: 7th overall pick in 1989 - Position: First baseman - Games played: 2,322 - Career stats: 521 home runs, .301 batting average, .974 on-base plus slugging - College/HS: Auburn University (Auburn, Ala.) - Wins above replacement: 73.8 - Draft: 36th overall pick in 1965 - Position: Catcher - Games played: 2,158 - Career stats: 389 home runs, .267 batting average, .817 on-base plus slugging - College/HS: Binger HS (Binger, Okla.) - Wins above replacement: 75.1 - Draft: 333rd overall pick in 1989 - Position: Shortstop - Games played: 2,543 - Career stats: 612 home runs, .276 batting average, .956 on-base plus slugging - College/HS: Illinois Central College (East Peoria, Ill.) - Wins above replacement: 73.1 - Draft: 8th overall pick in 1995 - Position: First baseman - Games played: 2,247 - Career stats: 369 home runs, .316 batting average, .953 on-base plus slugging - College/HS: University of Tennessee (Knoxville, Tenn.) - Wins above replacement: 61.8 - Draft: 2nd overall pick in 2004 - Position: Pitcher - Games played: 518 - Career stats: 260 wins, 3.25 earned run average, 1.12 walks plus hits per inning - College/HS: Old Dominion University (Norfolk, Va.) - Wins above replacement: 81.7 - Draft: 428th overall pick in 1988 - Position: Outfielder - Games played: 2,103 - Career stats: 130 home runs, .299 batting average, .794 on-base plus slugging - College/HS: University of Arizona (Tucson, Ariz.) - Wins above replacement: 68.4 - Draft: 29th overall pick in 1971 - Position: Shortstop - Games played: 2,707 - Career stats: 317 home runs, .305 batting average, .857 on-base plus slugging - College/HS: El Segundo HS (El Segundo, Calif.) - Wins above replacement: 88.6 - Draft: 25th overall pick in 2009 - Position: Centerfielder - Games played: 1,518 - Career stats: 378 home runs, .299 batting average, .991 on-base plus slugging - College/HS: Millville Senior HS (Millville, N.J.) - Wins above replacement: 86.1 - Draft: 7th overall pick in 2006 - Position: Pitcher - Games played: 425 - Career stats: 210 wins, 2.48 earned run average, 1.00 walks plus hits per inning - College/HS: Highland Park HS (Dallas, Texas) - Wins above replacement: 79.7 - Draft: 76th overall pick in 2007 - Position: First baseman - Games played: 1,589 - Career stats: 417 home runs, .258 batting average, .874 on-base plus slugging - College/HS: Notre Dame HS (Sherman Oaks, Calif.) - Wins above replacement: 44.3 - Draft: 3rd overall pick in 1973 - Position: Shortstop - Games played: 2,856 - Career stats: 251 home runs, .285 batting average, .772 on-base plus slugging - College/HS: William Howard Taft Charter HS (Woodland Hills, Calif.) - Wins above replacement: 77.4 - Draft: 55th overall pick in 1969 - Position: Pitcher - Games played: 692 - Career stats: 287 wins, 3.31 earned run average, 1.20 walks plus hits per inning - College/HS: Santiago HS (Garden Grove, Calif.) - Wins above replacement: 94.5 - Draft: 6th overall pick in 1992 - Position: Shortstop - Games played: 2,747 - Career stats: 260 home runs, .310 batting average, .817 on-base plus slugging - College/HS: Central HS (Kalamazoo, Mich.) - Wins above replacement: 71.3 - Draft: 96th overall pick in 1976 - Position: Outfielder - Games played: 3,081 - Career stats: 297 home runs, .279 batting average, .820 on-base plus slugging - College/HS: Oakland Technical HS (Oakland, Calif.) - Wins above replacement: 111.1 - Draft: 30th overall pick in 1971 - Position: Shortstop - Games played: 2,404 - Career stats: 548 home runs, .268 batting average, .908 on-base plus slugging - College/HS: Ohio University (Athens, Ohio) - Wins above replacement: 106.9 - Draft: 6th overall pick in 1985 - Position: Outfielder - Games played: 2,986 - Career stats: 762 home runs, .298 batting average, 1.051 on-base plus slugging - College/HS: Arizona State University (Tempe, Ariz.) - Wins above replacement: 162.8 - Draft: 86th overall pick in 1977 - Position: Shortstop - Games played: 2,573 - Career stats: 28 home runs, .262 batting average, .666 on-base plus slugging - College/HS: California Polytechnic State University, San Luis Obispo (San Luis Obispo, Calif.) - Wins above replacement: 76.9 - Draft: 2nd overall pick in 1985 - Position: First baseman - Games played: 1,976 - Career stats: 284 home runs, .303 batting average, .880 on-base plus slugging - College/HS: Mississippi State University (Mississippi State, Miss.) - Wins above replacement: 56.5 - Draft: 1st overall pick in 1993 - Position: Shortstop - Games played: 2,784 - Career stats: 696 home runs, .295 batting average, .930 on-base plus slugging - College/HS: Westminster Christian School (Miami, Fla.) - Wins above replacement: 117.6 - Draft: 402nd overall pick in 1999 - Position: Third baseman - Games played: 3,080 - Career stats: 703 home runs, .296 batting average, .918 on-base plus slugging - College/HS: Metropolitan Community College-Maple Woods (Kansas City, Mo.) - Wins above replacement: 101.4 - Draft: 3rd overall pick in 2006 - Position: Third baseman - Games played: 1,986 - Career stats: 342 home runs, .264 batting average, .804 on-base plus slugging - College/HS: California State University, Long Beach (Long Beach, Calif.) - Wins above replacement: 58.6 - Draft: 4th overall pick in 1986 - Position: Pitcher - Games played: 486 - Career stats: 211 wins, 3.28 earned run average, 1.22 walks plus hits per inning - College/HS: Georgia Institute of Technology (Atlanta, Ga.) - Wins above replacement: 67.8 - Draft: 17th overall pick in 1995 - Position: Pitcher - Games played: 416 - Career stats: 203 wins, 3.38 earned run average, 1.18 walks plus hits per inning - College/HS: Arvada West HS (Arvada, Colo.) - Wins above replacement: 64.2 - Draft: 36th overall pick in 1985 - Position: Pitcher - Games played: 618 - Career stats: 303 wins, 3.29 earned run average, 1.17 walks plus hits per inning - College/HS: University of Southern California (Los Angeles, Calif.) - Wins above replacement: 101.1 Data reporting by Karim Noorani. Story editing by Carren Jao. Additional editing by Kelly Glass. Copy editing by Robert Wickwire. Photo selection by Clarese Moller. This story originally appeared on ATS.io and was produced and distributed in partnership with Stacker Studio. - Draft: 295th overall pick in 1965 - Position: Pitcher - Games played: 807 - Career stats: 324 wins, 3.19 earned run average, 1.25 walks plus hits per inning - College/HS: Alvin HS (Alvin, Texas) - Wins above replacement: 81.3 Stay up-to-date on what's happening Receive the latest in local entertainment news in your inbox weekly!Omniverse Africa Announces Strategic Partnership With GIZ/DTC Nigeria For Omniverse Summit 2025NoneVANCOUVER, BC , Nov. 27, 2024 /PRNewswire/ - Sandstorm Gold Ltd. ("Sandstorm Gold Royalties", "Sandstorm" or the "Company") (NYSE: SAND) (TSX: SSL) is pleased to provide various developments within its diversified stream and royalty portfolio (dollar figures in USD unless otherwise indicated). Robertson Receives Approval of Key Environmental Permit On November 15 th , the U.S. Bureau of Land Management filed a positive Record of Decision for the Robertson mine, following publication of the project's Final Environmental Impact Statement ("EIS") and public review period. The Record of Decision is the last major Federal permit under the National Environmental Protection Act of 1969 ("NEPA"). Robertson is owned by Nevada Gold Mines ("NGM"), a joint venture between Barrick Gold Corp. and Newmont Corporation, and is located at the north end of Nevada's Cortez District. The project is less than 10 kilometres east of the Pipeline and Cortez Mine Complex, a well-known mining district that hosts NGM gold production from the operating Pipeline, Cortez, and Goldrush mines. Robertson is planned as an open-pit, heap leach operation that will utilize certain infrastructure and facilities at the Pipeline and Cortez Mine Complex. NGM most recently estimated first production at Robertson in 2027, subject to permitting, and feasibility work remains ongoing. For more information about the Robertson mine visit www.barrick.com . For information regarding the Record of Decision, visit the U.S. Bureau of Land Management's website at www.blm.gov and refer to the press release dated November 20, 2024 . Sandstorm has a 1.0%–2.25% sliding scale net smelter returns ("NSR") royalty on the Robertson project. At current gold prices, Sandstorm expects the upper-end of the sliding scale would apply to its royalty. Hod Maden Site Preparation Continues SSR Mining Inc. ("SSR Mining") reports that engineering studies and site preparation activities continue at its Hod Maden project in Türkiye, as the company continues to advance the project through to a construction decision. In the third quarter of 2024, approximately $10.9 million was spent at Hod Maden. SSR Mining will provide guidance on the expected 2025 capital spend at Hod Maden with its annual 2025 guidance. For more information, visit www.ssrmining.com and refer to the press release dated November 6, 2024 . Sandstorm holds a 2.0% NSR royalty and a 20% gold stream on the Hod Maden project. Under the terms of the Hod Maden gold stream, Sandstorm has agreed to purchase 20% of all gold produced from Hod Maden (on a 100% basis) for ongoing per ounce cash payments equal to 50% of the spot price of gold until 405,000 ounces of gold are delivered. Sandstorm will then receive 12% of the gold produced for the life of the mine for ongoing per ounce cash payments equal to 60% of the spot price of gold. Underground Development Commences at Hugo North Extension; Additional High-Grade Intercepts Released Entrée Resources Ltd. ("Entrée") announced the commencement of underground development work at Oyu Tolgoi Lift 1 Panel 1 on the Entrée/Oyu Tolgoi joint venture property in November. This initial phase involves up to 212 metres of lateral development in the southwest corner of the Hugo North Extension ("HNE"), as outlined in the 2024 Oyu Tolgoi Mine Plan, intended to support the development of mine infrastructure. Entrée continues to advance discussions with Rio Tinto and Oyu Tolgoi LLC ("OTLLC") to finalize either (i) the execution and delivery of the existing JV agreement between the parties or, (ii) conversion to an alternative agreement of equivalent economic value to govern their relationship during the development and mining stages of the Entrée/Oyu Tolgoi joint venture property. Entrée, Rio Tinto and OTLLC have identified a potential pathway forward, with corresponding definitive agreements subject to the approval of the entire OTLLC board. Entrée also released additional results from the 2023 drilling program at HNE, which includes both infill and extension holes from surface and underground. In addition to confirming long, high-grade intervals within the existing Hugo North Lift 2 block cave footprint, drill hole EGD 174 was terminated in mineralization at a depth of 1,800 metres, highlighting that the deposit remains open at depth with continuity for deeper potential lifts at Oyu Tolgoi. At depths, the Hugo North deposit dips to the northwest with an increasing proportion located on the Entrée/Oyu Tolgoi joint venture ground. Underground geotechnical holes UGD 807A, UGD 807B , and UGD 808 confirmed continuity of mineralization outside the potential Hugo North Lift 2 footprint. Highlights from the surface drill results include: Highlights from the underground drill results include: During 2024, drilling has continued at HNE with all holes targeting the potential Lift 2 mineralized footprint. As of October 31, 2024 , OTLLC had advised Entrée that approximately 5,287 metres of underground drilling in 23 diamond drill holes and 2,476 metres of surface drilling in four diamond drill holes had been completed. Entrée will report on the drill results once they have been received and reviewed. For more information, including full details of the drill results, visit www.entreeresourcesltd.com and refer to the press releases dated October 29 and November 4, 2024 . Sandstorm has a copper and precious metal stream with Entrée on the HNE whereby the Company has the right to purchase 0.42% of the copper, 5.62% of gold, and 4.26% of silver produced for ongoing cash payments of $0.50 per pound of copper, $220 per ounce of gold, and $5 per ounce of silver. Equinox Gold to Restart Mining at Aurizona Piaba Pit; Expansion Plans Ongoing Equinox Gold Corp. ("Equinox Gold") expects to resume mining at its Aurizona Piaba pit in the fourth quarter of 2024, following remediation from a geotechnical event caused by persistent heavy rains earlier in the year. Mining has been paused at Piaba since March 2024 , while ore feed at Aurizona has relied on existing stockpiles and mining from the Tatajuba open pit. A revised mine plan incorporating the Tatajuba, Boa Esperança, and Piaba pits has been prepared, and Equinox Gold has concluded that the geotechnical event does not have a significant negative impact on the long-term economic performance of Aurizona. Despite weather challenges, exploration activities in 2024 have included over 6,500 metres of regional drilling at Aurizona, focused on high potential targets. In the first nine months of 2024, nearly 3,500 metres of drilling has focused on resource delineation of the western extension of the Tatajuba deposit. Expansion plans at Aurizona aim to extend the mine life beyond 10 years and increase annual gold production through the development of an underground mine that would operate concurrently with the open pits. Engineering studies for the underground mine beneath the Piaba pit are ongoing, with efforts focused on refining ventilation systems, access layouts, and ore extraction plans. Construction of a portal and underground decline is expected to begin in 2025, enabling underground drilling and bulk sampling and ultimately supporting production operations. For more information, visit www.equinoxgold.com and refer to the company's 2024 third quarter Management Discussion & Analysis. Sandstorm has a sliding scale NSR royalty on the Aurizona mine, including the Piaba, Tatajuba, and Boa Esperança pits. When gold prices are above $2,000 per ounce, Sandstorm's royalty is a 5% NSR. Chapada Optimization Plan Improves Project Cash Flows Following optimization efforts at Lundin Mining Corporation's ("Lundin Mining") Chapada mine in Brazil , mining costs have decreased by 46% compared to 2022. In addition to improved haulage cycle times, fleet availability, and blasting fragmentation, the stockpile feed levels were also optimized. A redesigned mining plan was implemented with a lower annual stripping requirement, reducing annual mining rates by 30 million tonnes. These changes are expected to streamline operations while maintaining output, further improving free cash flow generated from the mine. Lundin Mining is concluding a scoping study on the Sauva deposit, and an updated technical report for the Chapada mine is expected to be filed in 2025. For more information, visit www.lundinmining.com and refer to Lundin Mining's conference call held on November 7, 2024 , discussing the company's 2024 third quarter financial results. Sandstorm holds a copper stream on the Chapada mine, whereby Sandstorm has agreed to purchased, for ongoing per pound cash payments equal to 30% of the spot price of copper, 4.2% of the copper produced up to maximum of 3.9 million pounds ("Mlbs") annually until 39 Mlbs are delivered, then 3.0% of the copper until 50 Mlbs are delivered; then 1.5% of the copper for the life of mine. Updated PEA for High-Grade Coringa Gold Project Serabi Gold plc ("Serabi") has published an updated Preliminary Economic Assessment ("PEA") for the Coringa gold project in Brazil , highlighting significant improvements compared to the 2019 study. Annual production is estimated at 28 thousand ounces ("koz") in 2025 then averaging 36 koz per year between 2026 and 2031 with an 11-year mine life until 2034. The updated PEA reflects an updated Mineral Resource Inventory at Coringa that includes Measured & Indicated Resources of 795 thousand tonnes ("kt") at 7.03 grams per tonne ("g/t") gold containing 179 koz gold and Inferred Resources are 1.45 million tonnes ("Mt") at 5.81 g/t gold containing 271 koz gold. The mine plan utilizes 81% of the total Measured & Indicated Resource inventory and 89% of Inferred Resources (3.16 g/t cut-off). The Coringa project has been in production since July 2022 as an underground operation using open stoping mining methods. Processing of Coringa ore is undertaken at Serabi's Palito Complex, utilizing existing process plant capacity. For more information, visit www.serabigold.com and refer to the press release dated October 21, 2024 . Sandstorm holds a 2.5% NSR royalty on the Coringa project. Notes 1. Drill hole EGD177 is the upper portion of "daughter" drill hole EGD177A, which was previously reported by Entrée Resources Ltd. on July 18, 2024. Qualified Person Imola Götz (M.Sc., P.Eng, F.E.C.), Sandstorm's Vice President, Mining & Engineering is a Qualified Person as defined by Canadian National Instrument 43-101. Ms. Götz has reviewed and approved the scientific and technical information in this news release. Contact Information For more information about Sandstorm Gold Royalties, please visit our website at www.sandstormgold.com or email us at info@sandstormgold.com . ABOUT SANDSTORM GOLD ROYALTIES Sandstorm is a precious metals-focused royalty company that provides upfront financing to mining companies and receives the right to a percentage of production from a mine, for the life of the mine. Sandstorm holds a portfolio of over 230 royalties, of which 41 of the underlying mines are producing. Sandstorm plans to grow and diversify its low-cost production profile through the acquisition of additional gold royalties. For more information visit: www.sandstormgold.com . CAUTIONARY STATEMENTS TO U.S. SECURITYHOLDERS The financial information included or incorporated by reference in this press release or the documents referenced herein has been prepared in accordance with International Financial Reporting Standards as issued by the International Accounting Standards Board, which differs from US generally accepted accounting principles ("US GAAP") in certain material respects, and thus are not directly comparable to financial statements prepared in accordance with US GAAP. This press release and the documents incorporated by reference herein, as applicable, have been prepared in accordance with Canadian standards for the reporting of mineral resource and mineral reserve estimates, which differ from the previous and current standards of the United States securities laws. In particular, and without limiting the generality of the foregoing, the terms "mineral reserve", "proven mineral reserve", "probable mineral reserve", "inferred mineral resources,", "indicated mineral resources," "measured mineral resources" and "mineral resources" used or referenced herein and the documents incorporated by reference herein, as applicable, are Canadian mineral disclosure terms as defined in accordance with Canadian National Instrument 43-101 — Standards of Disclosure for Mineral Projects ("NI 43-101") and the Canadian Institute of Mining, Metallurgy and Petroleum (the "CIM") — CIM Definition Standards on Mineral Resources and Mineral Reserves, adopted by the CIM Council, as amended (the "CIM Definition Standards"). For United States reporting purposes, the United States Securities and Exchange Commission (the "SEC") has adopted amendments to its disclosure rules (the "SEC Modernization Rules") to modernize the mining property disclosure requirements for issuers whose securities are registered with the SEC under the Exchange Act, which became effective February 25, 2019 . The SEC Modernization Rules more closely align the SEC's disclosure requirements and policies for mining properties with current industry and global regulatory practices and standards, including NI 43-101, and replace the historical property disclosure requirements for mining registrants that were included in SEC Industry Guide 7. Issuers were required to comply with the SEC Modernization Rules in their first fiscal year beginning on or after January 1, 2021 . As a foreign private issuer that is eligible to file reports with the SEC pursuant to the multi-jurisdictional disclosure system, the Corporation is not required to provide disclosure on its mineral properties under the SEC Modernization Rules and will continue to provide disclosure under NI 43-101 and the CIM Definition Standards. Accordingly, mineral reserve and mineral resource information contained or incorporated by reference herein may not be comparable to similar information disclosed by United States companies subject to the United States federal securities laws and the rules and regulations thereunder. As a result of the adoption of the SEC Modernization Rules, the SEC now recognizes estimates of "measured mineral resources", "indicated mineral resources" and "inferred mineral resources." In addition, the SEC has amended its definitions of "proven mineral reserves" and "probable mineral reserves" to be "substantially similar" to the corresponding CIM Definition Standards that are required under NI 43-101. While the SEC will now recognize "measured mineral resources", "indicated mineral resources" and "inferred mineral resources", U.S. investors should not assume that all or any part of the mineralization in these categories will be converted into a higher category of mineral resources or into mineral reserves without further work and analysis. Mineralization described using these terms has a greater amount of uncertainty as to its existence and feasibility than mineralization that has been characterized as reserves. Accordingly, U.S. investors are cautioned not to assume that all or any measured mineral resources, indicated mineral resources, or inferred mineral resources that the Company reports are or will be economically or legally mineable without further work and analysis. Further, "inferred mineral resources" have a greater amount of uncertainty and as to whether they can be mined legally or economically. Therefore, U.S. investors are also cautioned not to assume that all or any part of inferred mineral resources will be upgraded to a higher category without further work and analysis. Under Canadian securities laws, estimates of "inferred mineral resources" may not form the basis of feasibility or pre-feasibility studies, except in rare cases. While the above terms are "substantially similar" to CIM Definitions, there are differences in the definitions under the SEC Modernization Rules and the CIM Definition Standards. Accordingly, there is no assurance any mineral reserves or mineral resources that the Company may report as "proven mineral reserves", "probable mineral reserves", "measured mineral resources", "indicated mineral resources" and "inferred mineral resources" under NI 43-101 would be the same had the Company prepared the reserve or resource estimates under the standards adopted under the SEC Modernization Rules or under the prior standards of SEC Industry Guide 7. CAUTIONARY NOTE REGARDING FORWARD-LOOKING INFORMATION This press release contains "forward-looking statements", within the meaning of the U.S. Securities Act of 1933, the U.S. Securities Exchange Act of 1934, the Private Securities Litigation Reform Act of 1995 and "forward-looking information" within the meaning of applicable Canadian securities legislation, concerning the business, operations and financial performance and condition of Sandstorm Gold Royalties. Forward-looking statements include the future price of gold, silver, copper, iron ore and other metals, the estimation of mineral reserves and resources, realization of mineral reserve estimates, and the timing and amount of estimated future production. Forward-looking statements can generally be identified by the use of forward-looking terminology such as "may", "will", "expect", "intend", "estimate", "anticipate", "believe", "continue", "plans", or similar terminology. Forward-looking statements are made based upon certain assumptions and other important factors that, if untrue, could cause the actual results, performances or achievements of Sandstorm Gold Royalties to be materially different from future results, performances or achievements expressed or implied by such statements. Such statements and information are based on numerous assumptions regarding present and future business strategies and the environment in which Sandstorm Gold Royalties will operate in the future, including the receipt of all required approvals, the price of gold and copper and anticipated costs. Certain important factors that could cause actual results, performances or achievements to differ materially from those in the forward-looking statements include, amongst others, failure to receive necessary approvals, changes in business plans and strategies, market conditions, share price, best use of available cash, gold and other commodity price volatility, discrepancies between actual and estimated production, mineral reserves and resources and metallurgical recoveries, mining operational and development risks relating to the parties which produce the gold or other commodity the Company will purchase, regulatory restrictions, activities by governmental authorities (including changes in taxation), currency fluctuations, the global economic climate, dilution, share price volatility and competition. Forward-looking statements are subject to known and unknown risks, uncertainties and other important factors that may cause the actual results, level of activity, performance or achievements of the Company to be materially different from those expressed or implied by such forward-looking statements, including but not limited to: the impact of general business and economic conditions, the absence of control over mining operations from which the Company will purchase gold, other commodities or receive royalties from, and risks related to those mining operations, including risks related to international operations, government and environmental regulation, actual results of current exploration activities, conclusions of economic evaluations and changes in project parameters as plans continue to be refined, risks in the marketability of minerals, fluctuations in the price of gold and other commodities, fluctuation in foreign exchange rates and interest rates, stock market volatility, as well as those factors discussed in the section entitled "Risks to Sandstorm" in the Company's annual report for the financial year ended December 31, 2023 and the section entitled "Risk Factors" contained in the Company's annual information form dated March 27, 2024 available at www.sedarplus.com . Although the Company has attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements, there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking statements. The Company does not undertake to update any forward-looking statements that are contained or incorporated by reference, except in accordance with applicable securities laws. View original content to download multimedia: https://www.prnewswire.com/news-releases/sandstorm-gold-royalties-provides-updates-on-producing-and-key-development-assets-302317866.html SOURCE Sandstorm Gold Ltd.

Following a glittering array of new vessels in 2024, the cruise industry shows no signs of slowing down in 2025 with many major lines launching new cruise ships. From never-before-seen onboard attractions to luxurious accommodations and cutting-edge designs, these vessels promise to further develop the cruising experience for travelers in 2025 and well into the future. The Caribbean is the focus destination for new cruise ships in 2025. Each of these five new vessels will spend at least some of the year sailing in one of the world’s most popular cruising destinations . MSC’s ‘World America’ In recent years, Italian giant MSC Cruises has pushed hard into the U.S. market. From April 2025, MSC World America makes its debut in Miami. For the first time, MSC has crafted a brand new cruise ship with the American market firmly in mind. Cruisers already familiar with MSC World Europa will recognize much of what World America will offer, yet there are some key differences. The 22-deck ship will offer an adults-only “zen” zone and an outdoor “Family Aventura” zone featuring a water park, water slides, and a ropes course. This zone also features the Cliffhanger, the first over-water swing ride at sea that will allow cruisers to swing more than 150 feet beyond the side of the ship. On board, guests will find 13 dining venues including 6 specialty restaurants such as the ‘Butcher’s Cut’ steakhouse. The ship will also offer the fleet’s largest ‘Yacht Club’, MSC Cruises’ premium ship-within-a-ship concept. Royal Caribbean’s ‘Star of the Seas’ If you’ve been keen to try out Icon of the Seas , Royal Caribbean’s latest ship could be for you. Sister ship Star of the Seas will operate a series of 7-day Caribbean itineraries from Port Canaveral. It will feature 40 dining venues and bars, a waterpark, seven pools, with a maximum guest capacity of 7,600. With up to 2,350 crew on board, that means almost 10,000 people could call Star of the Seas home at any one time. As its sister ship, Star of the Seas will offer much the same experience as Icon , with improvements to family amenities. Notably, the upper age limit for the popular Surfside neighborhood will rise from six to 10, while the teen club will be refreshed. Icon’s Empire Supper Club will be replaced with a Chicago-themed Lincoln Park Supper Club, while a new restaurant concept is planned for Surfside. NCL’s ‘Norwegian Aqua’ One common criticism of NCL’s otherwise popular ‘Prima’ class of cruise ship has been that some of the onboard venues are relatively small. It seems NCL has paid attention, for its new Norwegian Aqua has been designed with extra space, especially outside. There’s more seating at the Infinty pools and more space in the Vibe Beach Club, for example. Set to appeal to solo cruisers with dedicated cabins and facilities, Norwegian Aqua will also have the “highest staffing levels of any new contemporary cruise ship” according to the company. The ‘Aqua Slidecoaster’ is the world's first hybrid rollercoaster and waterslide at sea, allowing two people to race. Inside, the Glow Court promises a futuristic sports court with LED and neon lights. Norwegian Aqua will sail regularly to Bermuda from New York and to the Caribbean from Port Canaveral and Miami. Virgin Voyages’ ‘Brilliant Lady’ Brilliant Lady , Virgin Voyages' fourth ship, debuts in September 2025 following construction delays. With 1,408 cabins, 86% featuring balconies, plus luxurious suites and solo accommodations, the new ship will carry up to 2,700 guests. Like its sister ships, Brilliant Lady will offer a non-standard cruising experience, with fares including Wi-Fi, gratuities, a basic beverage package, and signature fitness classes. The ship avoids the traditional main dining room and buffet setup, instead offering a choice of around 20 dining venues. Itineraries start in New York with trips to Bermuda and Quebec, then move to Miami for winter Caribbean cruises, including Aruba and Ocho Rios. A Panama Canal crossing leads to West Coast voyages and Virgin Voyages’ first Alaska season in summer 2026. Disney Cruise Line’s ‘Disney Destiny’ Disney Destiny , launching in November 2025, will be Disney Cruise Line’s third Wish-class ship, carrying 4,000 passengers. Themed around heroes and villains, it features new venues, shows, and designs, including Pride Lands: Feast of The Lion King, Marvel’s Spider-Man on the stern, and Minnie Mouse filigree art on the bow. Dining highlights include Worlds of Marvel, 1923, and the exclusive Edna A La Mode Sweets. Adult-only spaces feature fine dining, a spa, and an infinity pool. Powered by LNG, Disney Destiny has 1,238 staterooms, most featuring Disney’s split-bath designs—with a bathtub/shower and sink in one room and separate toilet and sink in another. Disney Destiny will offer four- and five-night cruises from Fort Lauderdale to the Bahamas and Caribbean, featuring stops at Disney’s private islands, Castaway Cay and Lookout Cay at Lighthouse Point, which opened in June 2024. If you enjoy visiting private islands, watch out for itineraries that will visit both islands. Other New Cruise Ships In 2025 While these five eye-catching new cruise ships have dominated headlines, there are several other intriguing vessels awaiting launch. Debuting in September 2025, Star Princess will be Princess Cruises' second Sphere-class ship, 20% larger than its predecessors, and the 17th in the fleet. Featuring expanded accommodations, including new Reserve and Signature Collections, it continues the line’s heritage with a fresh design and is the third ship to bear the name. By the end of 2025, Celebrity Cruises should have launched Celebrity Xcel , the fifth Edge-class ship. Debuting in November with alternating seven-night Caribbean itineraries from Fort Lauderdale, the 3,260-passenger vessel will feature signature spaces like The Retreat, the Magic Carpet, and Sunset Bar. Although “bigger is better” is a clear trend among new cruise ships, not all lines are playing ball. Set to launch in summer 2025, the adult-only Viking Vesta from Viking Ocean Cruises will carry a maximum of 998 guests. Although being slightly longer than its predecessors because of advanced marine technology, the onboard experience will feel immediately familiar to fans of the line. MORE FROM FORBESDecember 11, 2024 This article has been reviewed according to Science X's editorial process and policies . Editors have highlightedthe following attributes while ensuring the content's credibility: fact-checked peer-reviewed publication trusted source proofread by Carnegie Institution for Science A team of researchers led by Carnegie Science's Will Ludington, Karina Gutiérrez-García, and Kevin Aumiller identified genes that enable a beneficial bacterial species to colonize specific regions of the gastrointestinal tract. Their work, published in Science , could revolutionize our understanding of how the composition of the gut microbiome is determined and open the door to microbiome engineering. The gut microbiome is an ecosystem of hundreds to thousands of microbial species living within the human body and influencing our health, fertility, and even longevity. These populations can aid digestion, inform immune responses, and help fight off pathogens among other functions. However, the microbiome isn't uniform throughout the gut. Just as various organs within the gastrointestinal system have different specialties when it comes to digesting food and absorbing nutrients, different microbial communities are localized within each zone and play unique roles there. Successful colonization of each region of the G.I. tract by different microbial populations is dependent on a variety of factors such as nutrient requirements of the bacteria; the local pH and dissolved oxygen content ; competition with other bacterial strains; and survivability in harsh conditions —including stomach acid, bile salts, and immune-response cells. "We're talking about an incredibly complex system of interconnected microbial communities, and each species needs to get to the right place where it can thrive and contribute to host health," explained Ludington, who has been probing microbiome acquisition and composition for several years at Carnegie. "Researchers have been trying to figure out how each bacterial species is directed to the right location and how colonization by harmful or less-than-ideal species is minimized." Think about checked luggage moving through the system of conveyor belts behind the scenes at a busy, urban airport. The baggage handling system may look disorganized and chaotic, but the majority of bags get to the plane where they need to be. And processes are in place to correct any erroneous sorting that occurs over time. "Likewise, in the gut, beneficial bacteria need to get to the region where they can successfully create a colony," co-lead author Gutiérrez-García indicated. "We worked to reveal the mechanisms that enable this to happen." Successful colonization hinges on proteins in bacterial cell walls called adhesins. As you might guess from their name, they can stick to a variety of different surfaces within the body. But they typically bind non-specifically, meaning they could just as soon attach to one tissue as another. So how do symbiotic microbiome species get to the place they need to go? To tackle this mystery, Ludington, Gutiérrez-García, Aumiller and their colleagues developed technology that enabled them to watch a single cell of the bacterial species Lactiplantibacillus plantarum colonize its niche within the fruit fly gut in real time. The team also included Carnegie's Ren Dodge, Benjamin Obadia, Haolong Zhu, and Ru-Ching Hsia, as well as Ann Deng, Sneha Agrawal, and Xincheng Yuan from Johns Hopkins University and, Richard Wolff and Nandita Garud from UCLA. Discover the latest in science, tech, and space with over 100,000 subscribers who rely on Phys.org for daily insights. Sign up for our free newsletter and get updates on breakthroughs, innovations, and research that matter— daily or weekly . The fruit fly may be a pest in the kitchen, but it's a workhorse in the laboratory and the perfect organism for this type of research, because the species that comprise its microbiome are well defined and small in number. Watching the events unfold in such high-resolution detail enabled the scientists to see the difference between short-lived colonization and long-term success. "Developing this imaging technique was an exciting challenge," said Dodge, a key contributor to the study. "It allowed us to see the interactions of individual bacteria cells with the host gut in unprecedented detail." They found that L. plantarum isolated from the guts of wild fruit flies was able to stably attach to host tissue whereas L. plantarum from humans and other sources formed only transient attachments. With this information in hand, the researchers set out to determine the genetic basis for this super-affinity. Through diligent and painstaking work, they were able to identify a set of genes for symbiotic gut colonization within a niche. "By identifying the genes that enable L. plantarum to colonize specific niches, we now have the insights into how to engineer greater precision into other bacteria," said Aumiller, a co-lead author on the project. "This opens the door to creating probiotics that are optimized for specific niches in the human gut." "Looking ahead, we will attempt to elucidate the mechanism underlying this binding specificity," Ludington concluded. More information: Karina Gutiérrez-García et al, A conserved bacterial genetic basis for commensal-host specificity, Science (2024). DOI: 10.1126/science.adp7748 Journal information: Science Provided by Carnegie Institution for Science

Photos You Can’t Miss! Kana Nishino’s Stunning 2024 MomentsLosses for big technology stocks pulled major indexes lower on Wall Street. The S&P 500 fell 0.4% Wednesday. The Dow Jones Industrial Average slipped 0.3% from its record high a day earlier, and the Nasdaq composite lost 0.6%. Losses for Nvidia, Microsoft and Broadcom were the biggest weights on the market. Dell sank 12.2% after reporting revenue that fell shy of forecasts, and HP dropped 11.4% after giving a weaker-than-expected outlook. Treasury yields fell in the bond market. U.S. financial markets will be closed Thursday for Thanksgiving, and will reopen for a half day on Friday. THIS IS A BREAKING NEWS UPDATE. AP’s earlier story follows below. Stocks wavered in afternoon trading on Wednesday, as losses for several Big Tech companies offset gains elsewhere in the market. The S&P 500 fell 0.4% in afternoon trading, even though more stocks were rising than falling in the index. The Dow Jones Industrial Average fell 135 points, or 0.3%, as of 3:05 p.m. Eastern time. Both indexes set records on Tuesday. The Nasdaq composite fell 0.5%. Losses for tech heavyweights helped pull the broader market lower. Semiconductor giant Nvidia slipped 1.6%. Its huge value gives it outsized influence on market indexes. Microsoft fell 0.9% Several personal computer makers added to Big Tech's heavy weight on the market following their latest earnings reports. HP sank 11.8% after giving investors a weaker-than-expected earnings forecast for its current quarter. Dell slumped 11.9% after its latest quarterly revenue fell short of Wall Street forecasts. Gains for financial and health care companies helped counter Big Tech's downward pull. Visa rose 0.9% and Thermo Fisher Scientific added 2.3%. The U.S. economy expanded at a healthy 2.8% annual pace from July through September, according to the Commerce Department, leaving its original estimate of third-quarter growth unchanged. The growth was driven by strong consumer spending and a surge in exports. The update follows a report on Tuesday from the Conference Board that said confidence among U.S. consumers improved in November, but not by as much as economists expected. Consumers have been driving economic growth, but the latest round of earnings reports from retailers shows a mixed and more cautious picture. Department store operator Nordstrom fell 8.5% after warning investors about a trend toward weakening sales that started in late October. Clothing retailer Urban Outfitters jumped 19.1% after beating analysts’ third-quarter financial forecasts. Weeks earlier, retail giant Target gave investors a discouraging forecast for the holiday season, while Walmart provided a more encouraging forecast. Consumers, though resilient, are still facing pressure from inflation. The latest update from the U.S. government shows that inflation accelerated last month. The personal consumption expenditures index, or PCE, rose to 2.3% in October from 2.1% in September. Overall, the rate of inflation has been falling broadly since it peaked more than two years ago. The PCE, which is the Federal Reserve's preferred measure of inflation, was just below 7.3% in June of 2022. Another measure of inflation, the consumer price index, peaked at 9.1% at the same time. The latest inflation data, though, is a sign that the rate of inflation seems to be stalling as it falls to within range of the Fed's target of 2%. The central bank started raising its benchmark interest rate from near-zero in early 2022 to a two-decade high by the middle of 2023 and held it there in order to tame inflation. The Fed started cutting its benchmark interest rate in September, followed by a second cut in November. Wall Street expects a similar quarter-point cut at the central bank's upcoming meeting in December. “Today’s data shouldn’t change views of the likely path for disinflation, however bumpy," said David Alcaly, lead macroeconomic strategist at Lazard Asset Management. "But a lot of observers, probably including some at the Fed, are looking for reasons to get more hawkish on the outlook given the potential for inflationary policy change like new tariffs.” President-elect Donald Trump has said he plans to impose sweeping new tariffs on Mexico, Canada and China when he takes office in January. That could shock the economy by raising prices on a wide range of goods and accelerating the rate of inflation. Such a shift could prompt the Fed to rethink future cuts to interest rates. Treasury yields slipped in the bond market. The yield on the 10-year Treasury fell to 4.25% from 4.30% late Tuesday. The yield on the two-year Treasury, which more closely follows expected actions by the Fed, fell to 4.22% from 4.25% late Tuesday. U.S. markets will be closed Thursday for Thanksgiving, and will reopen for a half day on Friday. Damian J. Troise And Alex Veiga, The Associated PressDAYTONA BEACH, Fla. (AP) — Kobe Magee had 23 points in Drexel's 83-71 win against Chicago State on Tuesday. Magee had nine rebounds for the Dragons (5-3). Yame Butler shot 6 of 10 from the field and 8 for 11 from the line to add 20 points. Cole Hargrove went 5 of 7 from the field to finish with 10 points. Troy McCoy finished with 19 points and six rebounds for the Cougars (0-8). Jalen Forrest added 14 points for Chicago State. Matthew Robinson finished with 10 points and two steals. Story continues below video Jason Drake led Drexel in scoring with eight points in the first half to help put them up 35-28 at the break. Magee scored 16 points in the second half. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .

It was a Netflix documentary Michael Nantais watched during the early months of the pandemic that cemented his love of sustainable farming. Nantais, who grew up just outside of Montreal in Pointe-Claire, started experimenting in his mother’s backyard; growing kale, cucumbers, and zucchinis for the first time more than four years ago. “I didn’t really know much at that time,” the now 26-year-old said. “I was buying seedlings and planting them.” Then came the rush of changes to his life and career plans. Nantais switched from an economics degree at university to a biology program to learn more about plants. He focused on learning everything about farming, first from a plant soil lab, later at a vertical farm in Montreal. Vertical farming stacks crops vertically in layers, typically in an indoor setup, which allows farmers to control lighting, humidity, and temperature. It’s gaining popularity, especially in urban areas. “Was my mind set on vertical farming when I switched to biology? The answer is no,” Nantais recalled. “I was open-minded ... I just wanted to learn,” he said. Younger Canadians may not own the farmland or heavy machinery needed to launch traditional agriculture careers, but they are equipped with technology. That’s changing how they get their foot in the door even when they don’t come from farm families. Traditionally, many agriculture students came from rural areas and , said Jay Steeves, dean of Werklund School of Agriculture & Technology at Olds College in Alberta. Now, more are joining agricultural programs at schools, and graduates are finding niche areas of the field. “It’s not just that broad acre farming with large operations,” said Steeves. “We’re starting to see indoor agriculture, the idea of produce and food creation for a growing population.” Steeves recalled a school project a year ago when a student grew lettuce in their dorm room and was able to control different environments, moisture and light intensity remotely. “That idea of a student or an individual in a small, little dorm room with a growing operation the size of a mini-fridge is part of agriculture at this point in time,” Steeves said, “and is now producing food that can be used and consumed by anyone on the planet.” Innovation is key for aspiring farmers, said Craig Klemmer, principal economist at Farm Credit Canada. Starting small could be the first step. “With the changing face of the Canadian population, it’s creating new opportunities for markets,” he said. For instance, there’s been a growing demand for sheep and goat meat, which can be started small and scaled up. Others are looking into more niche areas of the sector, he said growing herbs or working in sustainable farming which need fewer capital investments and resources to get operations going. “When you look at the opportunities, it’s more on the smaller niche,” Klemmer said. “Finding a new and creative solution, making some partnerships would be good ways to start.” Nantais moved to Toronto last year to set up his own vertical farm business with an investment from his uncle but ran into a logistical issue: Finding an appropriate rental space for the operation. He decided instead to partner with an existing vertical farm, Living Earth Farm, which grows sunflowers, peas, radishes, basil, cilantro and arugula, among other microgreens. He operates the farm as a partner and plans to be there for a while. “Hopefully, we can expand, increase our supply and start selling more of it.” Exploring niche areas of farming comes at a time when the costs of farmland and farm machines have gone up exponentially over the years. The price of farmland in southern Ontario has gone up from an average of $2,616 per hectare in 1996 to approximately $23,100 per hectare in 2023, according to Farm Credit Canada’s historical farmland values report. Other provinces have seen similar price jumps. “The reality, if we look at traditional crop production in Canada at large scale, they are very high barriers to entry,” Klemmer said. “It would require quite a bit of capital to make those investments.” That means not everyone is in a position to own a facility or run farmland, no matter the size. Steeves said many young graduates from the agricultural college are pivoting to areas such as crop science and working with larger producers to help them become more efficient. “A farmer isn’t your classic picture (of a) person standing in the field, getting their hands dirty working with animals,” Steeves said. Field work including drone assessments, pest management and soil testing are jobs increasingly finding a place among modern agriculture workers who want to be a part of the food system but can’t own their own operations. “It’s not so much operating and owning but doing more of the consulting for production,” Steeves said. can go a long way for a young farmer. Just like any other job, Steeves said, aspiring farmers need soft skills such as networking and the ability to move around for jobs. Despite rising interest in farming and a growing culture of grow-your-own-food, there remains a shortage in labour supply in the farming sector. As a large number of Canadian farmers head into retirement, fewer young people are stepping up to take on those roles. About 61 per cent of Canadian farm operators were 55 and older, according to a 2021 Statistics Canada report. Meanwhile, the number of farmers under 35 fell to 8.6 per cent as of 2021, compared with 11.5 per cent in 2001. “I think we still need more people,” Steeves said. He said there’s a place for everyone to be a part of agriculture if not at the farmer or producer level and still feel connected to the industry. “We’re still trying to get rid of that myth that you have to come from this background in order to be involved,” Steeves said. This report by The Canadian Press was first published Dec. 21, 2024.US Provides $400,000 To Preserve Ancient Nigerian EarthworksBrazil's federal police said Thursday that they had indicted former President Jair Bolsonaro and 36 other people for allegedly attempting a coup to keep him in office after his defeat in the 2022 elections. Police said their findings were being delivered Thursday to Brazil's Supreme Court, which must decide whether to refer them to Prosecutor-General Paulo Gonet, who will either formally charge Bolsonaro and put him on trial or toss the investigation. The former right-wing president has denied that he tried to stay in office after his narrow electoral defeat in 2022 to his rival, leftist President Luiz Inacio Lula da Silva. Bolsonaro has faced a series of legal threats since then. Police said in a brief statement that the Supreme Court had agreed to reveal the names of all 37 people who were indicted "to avoid the dissemination of incorrect news." The 700-page police document likely will take several days for the court to review, Supreme Court Justice Alexandre de Moraes said. The others indicted included General Walter Braga Netto, who was Bolsonaro's running mate in the 2022 campaign; former Army commander General Paulo Sergio Nogueira de Oliveira; Valdemar Costa Neto, the chairman of Bolsonaro's Liberal Party; and his veteran former adviser, General Augusto Heleno. The investigation started last year. On Tuesday, four military officers and a federal police officer were arrested as part of the same probe. They were accused of plotting to overthrow the government following the 2022 elections, including alleged plans to kill Lula and other top officials. Other investigations focus on Bolsonaro's potential roles in smuggling diamond jewelry into Brazil without properly declaring it, and in directing a subordinate to falsify his and others' COVID-19 vaccination statuses. Bolsonaro has denied any involvement in either. Another probe found that he had abused his authority to cast doubt on the country's voting system, and judges barred him from running again until 2030. The far-reaching investigations have weakened Bolsonaro's status as a leader of Brazil's right wing, said Carlos Melo, a political science professor at Insper University in Sao Paulo. "Bolsonaro is already barred from running in the 2026 elections," Melo told The Associated Press. "And if he is convicted, he could also be jailed by then. To avoid being behind bars, he will have to convince Supreme Court justices that he has nothing to do with a plot that involves dozens of his aides. That's a very tall order."

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