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SANTA CLARA — When Isaac Guerendo trots onto the field with the first team Sunday at Levi’s Stadium, he will equal the same number of starts he had in five years of college football. Hard to believe, but Guerendo started exactly one time, and it came in his final college game at Louisville. Against USC in the Holiday Bowl, Guerendo carried 23 times for 161 yards and three touchdowns and added five receptions in a 42-28 loss. In 40 other games at Wisconsin and Louisville, Guerendo played in a shared backfield –something he’s done with the 49ers this season behind Jordan Mason and Christian McCaffrey . With McCaffrey on injured reserve with a PCL strain and Mason to follow soon with a high ankle sprain, Guerendo should get his biggest workload since his last college game. “I’m excited, but really it’s whatever it takes to win,” Guerendo said Wednesday as the 49ers (5-7) began preparations to host the Bears (4-8). “Whatever the plan looks like is what we’ll bring.” Guerendo will be backed up by Patrick Taylor Jr., who was on the roster earlier this season when McCaffrey was dealing with bilateral Achilles tendinitis, then re-signed to the practice squad. Taylor was promoted Tuesday, and the 49ers also made a waiver claim on former Jets running back Israel Abanikanda. “I think he’s ready to go,” 49ers coach Kyle Shanahan said. “He had some ups and downs but got better through everything. I think he’s ready for this.” Guerendo, 6-foot and 219 pounds, has 42 carries for 246 yards and two touchdowns, averaging a gaudy 5.9 yards per carry. His 15-yard run in the third quarter was the 49ers’ lone touchdown in a 35-10 loss to the Buffalo Bills. The 49ers traded up to get Guerendo in the fourth round, only to see him sidelined with a hamstring strain in his first training camp practice. A speedy wide receiver at Avon High School in Indiana who also ran track and played basketball, Guerendo carried 10 times for 99 yards with a long run of 76 against Seattle and 14 times for 85 yards against Dallas. At Wisconsin, Guerendo played behind Jonathan Taylor, now a star running back for the Indianapolis Colts. He split time as a graduate student at Louisville with Jawhar Jordan, who rushed for 1,128 yards while Guerendo had 810 yards on 132 carries and a 6.1-yard average. The good news is Guerendo’s body hasn’t taken on the normal amount of abuse for a running back. And Guerendo feels he’s up to the challenge after playing 12 games with old-school running backs coach Bobby Turner. “I always give credit to Coach T for preparing everybody like they’re going to be the starter, so that when moments do come, you’re ready for it,” Guerendo said. McCaffrey appeared to have finally gotten untracked against the Bills, gaining 53 yards on seven carries before getting tripped up on a 19-yard burst in the second quarter. But the tackle injured his knee, Mason injured his ankle, and Guerendo became the lead runner for a team that is sixth in the NFL in rushing. Over time, Guerendo has become accustomed to the speed of the NFL game. “I think it takes guys some time,” Shanahan said. “You start to get a feel for it, if you’ve got the right stuff, you get more reps and the more you adjust to it. How hard you’ve got to hit stuff, how quick those holes close, how you have to hit it full speed and can’t hesitate. We’ve seen that stuff get better in practice and we’ve seen it carry over into games.” McCaffrey, meanwhile, took to social media in the form of a lengthy Instagram post to explain how he was feeling after his latest injury. He wrote of his love for football, how humbling it is and his desire to return. “This wasn’t my year, and sometimes when it rains, it pours,” McCaffrey wrote. “You can feel sorry for yourself and listen to the birds, or you can hold the line. I’m grateful for the support of everyone in my corner and promise I’ll work smarter and harder to come back better from this.” For those who dream big, Shanahan said with a six-week time frame, McCaffrey could conceivably return if the 49ers reach the postseason. THE INJURY LIST Those who didn’t practice Wednesday included edge rusher Nick Bosa (hips, obliques), left tackle Trent Williams (ankle), left guard Aaron Banks (concussion), Mason (ankle) and linebacker Demetrius Flannigan-Fowles (ankle). Cornerback Deommodore Lenoir (knee), linebacker Dre Greenlaw (Achilles) and safety Talanoa Hufanga (wrist) were limited. Defensive tackle Jordan Elliott has cleared concussion protocol after missing the Buffalo game. Hufanga joined Greenlaw as practicing during a 21-day window. Shanahan said it’s more likely Greenlaw would be activated before a Thursday night game against the Los Angeles Rams on Dec. 12 than against Chicago. HUFANGA AND THE CLUB After recovering from an ACL tear last season, Hufanga has played in just two games this season. First, he was felled by an ankle injury, and then a wrist injury that needed surgery. When activated, he’ll play with a protective club on his right hand. “I was still dealing with the ankle. I was about to get it re-wrapped and for some reason my hand wouldn’t open,” Hufanga said. Hufanga said he’ll try to use the protective device as a benefit rather than a detriment. “I had a good friend back in the day who played with a club who had three picks in one game, so you never know,” Hufanga said. MOORE FARES WELL Left tackle Jaylon Moore acquitted himself well for the second straight game in starting in place of Williams. “It was OK, but you can always get better and that’s what I’m focusing on — the things I can get better at,” Moore said. Tight end George Kittle noted last week that Moore was at left tackle all through training camp during Williams’ holdout, so it’s not like he hasn’t been with the first team. “It definitely did help, especially being comfortable with the group,” Moore said. “The quarterback’s cadence, the guy you’re next to, all the small stuff comes into play.”CALGARY, Alberta (AP) — A Ukrainian girls’ hockey team is in Canada for a few days of peace and hockey in an arena that doesn’t have a missile-sized hole in its roof. After 56 hours of travel to Calgary, including a 24-hour bus ride from Dnipro to Warsaw, Poland, that required army escort for a portion of it, the Ukrainian Wings will join Wickfest, Hayley Wickenheiser’s annual girls’ hockey festival, on Thursday. The squad of players aged 11 to 13 was drawn from eight different cities in Ukraine, where sport facilities have been damaged or destroyed since Russia started its invasion in February 2022. “They all have a personal story of something awful happening,” said Wickenheiser. “We give them a week of peace and joy here, and I hope they can carry that with them. “We know full well they’re going back to difficult circumstances. It’s tough that way.” Nine players are from Kharkiv, where pictures show a large hole in the roof of the Saltovskiy Led arena where the girls’ team WHC Panthers once skated. “It was our home ice arena, and we played all our national team championships in this ice arena,” said Kateryna Seredenko, who oversees the Panthers program and is the Wings general manager. Ukraine’s Olympic Committee posted photos and wrote in a Facebook post Sept. 1 that Kharkiv’s Sport Palace, which was home to multiple hockey teams, was also destroyed in an attack on the city. Seredenko says the Wings’ arduous journey to Calgary was worth it because it gives the girls hope. “It’s not a good situation in Ukraine, but when they come here, they can believe that everything will be good, everything will be fine, of course we will win soon and we must play hockey. We can’t stop because we love these girls and we will do everything for them,” she said. “So many girls on this Ukrainian team are future players of the national team.” Wickenheiser, a Hockey Hall of Famer , is the assistant general manager of player development for the Toronto Maple Leafs and a doctor who works emergency room shifts in the Toronto area. The six-time Olympian and four-time gold medalist organized her first Wickfest after the 2010 Winter Games. She’s had teams from India, Mexico and the Czech Republic attend over the last decade and a half, but never a team that ran the Ukrainians’ gauntlet of logistics. The Canadian Partnership for Women and Children’s Health took on the task of arranging visas and paying for the team’s travel. “We care about women and children’s health. Sport is such a symbol. When you see a group of girls coming off the ice all sweaty and having worked hard on the ice, it’s a symbol of a healthy girl,” said chief executive officer Julia Anderson. “That’s a healthy kid that’s able to participate in sport. We really believe if we can get girls there, whether they’re in an active war zone, or here in Canada, those girls will change the world.” The Wings aren’t the first Ukrainians to seek a hockey haven in Canada since the war began. An under-25 men’s team played four games against university squads in early 2023 to prepare for that year’s world university games. Ukrainian teams have also twice played in the Quebec City International Pee-Wee Hockey Tournament. “It’s the first time in Ukrainian history where a girls’ team is coming to Canada to a very good tournament,” Seredenko said. “They can see how they can play in their future. And they can see how it is to play hockey in Canada.” ___ AP sports: https://apnews.com/sports The Associated Press
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Biden’s pardon hurts justiceAs tensions rise between the Pakistan Tehreek-e-Insaf (PTI) and the government following the apparent failure of "do-or-die" protest, the former ruling party has vowed to pursue a civil disobedience movement if its demands, which include the release of "political prisoners", are not met. "Release our workers and a judicial inquiry should be launched in May 9 events and the late-night crackdown on protesters on November 26," Opposition Leader in the National Assembly Omar Ayub said while addressing a press conference in Peshawar on Sunday. Last week, incarcerated PTI founder Imran Khan — in a post on X — warned the government of launching a "civil disobedience" movement from December 14 if his demands are not met. The ousted prime minister also constituted a five-member negotiation committee comprising Omar Ayub Khan, Ali Amin Gandapur, Sahibzada Hamid Raza, Salman Akram Raja and Asad Qaiser. The committee, he said, would negotiate with the federal government on two points — the release of “political prisoners” facing trial and the constitution of a judicial commission to probe the events of May 9, 2023 and a late-night crackdown on PTI protesters on November 26. Addressing the presser today, Omar said that the committee was ready to hold talks with every stakeholder in the country. He castigated the government for allegedly using live ammunition against the "peaceful protesters", saying that 12 PTI workers were killed during the protest. "Over 200 workers are still missing while more than 5,000 were arrested," he claimed. For his part, Opposition Leader in the Senate Shibli Faraz claimed that the PTI’s mandate was stolen in the February 8 general elections. "Issues should be resolved through dialogue," he said while condemning the government’s "use of force". The former ruling party's much-hyped protest in Islamabad, aimed at securing the PTI founder's release who has been behind bars for more than a year, culminated in the party’s hasty retreat after the government's midnight crackdown on the protesters. The Imran-founded party has since claimed that at least 12 of its workers were killed and 1,000 were arrested. However, the government has categorically denied using live ammunition against the protesters and said that four law enforcers including three Rangers personnel and a policeman were martyred during the protest. The federal government has strongly reacted to Imran Khan's civil disobedience's call, with ruling leaders saying that the PTI’s new strategy is destined to fail just like its "previous attacks on Islamabad". "Civil disobedience [movement] becomes successful when the people are not dependent on the state," said Defence Minister Khawaja Asif while speaking to Geo News , adding that the state is providing all facilities to the nationals. He was of the view that such movements had made impacts during the British era and said: "Whoever tabled this suggestion to the PTI is seemingly unaware of history." Meanwhile, PM's aide Rana Sanaullah also predicted that the former ruling party would fail to achieve its desired goals and ruled out holding "conditional talks" with the opposition party. "We haven't shut the door on negotiations," said Sanaullah speaking on Geo News programme "Naya Pakistan", adding that they are ready for political talks with the PTI to resolve dispute on contentious matters. He predicted that the opposition party's civil disobedience call is bound to fall flat as the party suffered an "irreparable political loss" following the Islamabad protest fiasco.
Deion Sanders continues to be the talk of the football world - both college football and NFL. The former NFL star, who dominated at cornerback for the Cowboys, Falcons, 49ers and others, has since gotten into coaching. He's in Year 2 at Colorado, leading the Buffaloes to an 8-3 start. Colorado remains in the hunt for a Big 12 Championship and possible College Football Playoff berth, though the Boulder program is going to need a lot of help this weekend. While Colorado plays out the 2024 season, Coach Prime continues to get linked to NFL jobs - most notably, the Dallas Cowboys gig, which could open up if Mike McCarthy gets fired. According to former Cowboys star Michael Irvin, Deion Sanders would absolutely take the job, on one condition - if Dallas drafts his son, Shedeur Sanders. "100%. And I can tell you, good sources have told me that. Great sources have told me that," Irvin told Colin Cowherd earlier this month. Andrew Wevers/Getty Images While Deion Sanders talks a lot, he hasn't made a ton of statements about his politics. However, over the years, he's made it pretty clear where he stands. Back in 2017, Deion Sanders aligned with some Republican billionaires. While Coach Prime might be center, or even left of center, he's not so far left that he'll refuse to work with those on the right. He worked with Republican billionaires David and Charles Koch, and took some heat from it. But Deion Sanders, who starred in the NFL from 1988-2005, has made it clear that he doesn't discriminate based on politics. ”You talk about a family that has one desire: to make this country a better place,” Sanders reportedly said . “To level the playing field, to inspire, encourage, motivate. And that’s what they do, and that’s who they are, and I’m thankful to be partnered with them.” “I think I chose correctly,” he said. “I’m happy where I am and who I’m with, because we share a lot of the same values and goals, and I’m thankful to be part of this team.” Deion Sanders has made it clear that he'll do whatever it takes to help the less fortunate. “We are committed to helping people improve their lives,” Sanders said. “This is an opportunity to provoke real change in our community and provide effective assistance to those who live in constant struggle.” Andrew Wevers/Getty Images Coach Prime is likely on the side of most Americans - able to get along with pretty much everyone, outside of maybe those on the extremes. Colorado, meanwhile, is set to finish its 2024 regular season on Friday, taking on Oklahoma State.
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SEAN DIETRICH: Warning: Do not trust anyone who looks like meRoivios Initiates Landmark Study to Demonstrate Safety and Efficacy of an Innovative Renal Assist Device for Cardiac Surgery Patients With Kidney Disease NASSAU, Bahamas , Dec. 19, 2024 /PRNewswire/ -- Roivios , a pioneering clinical-stage medical device company dedicated to revolutionizing kidney health, proudly announces that its research and development arm, 3ive Labs, has secured approval for an Investigational Device Exemption (IDE) from the FDA. This approval paves the way for a pivotal trial of the JuxtaFlow Renal Assist Device (RAD), marking a transformative step forward in enhancing outcomes for cardiac surgery patients with renal insufficiency. The GRADIENT ( G roundbreaking R enal A ssist D evice I ntervening to EN hance cardio T horacic surgery outcomes) trial is designed to address the critical need for renal support among cardiac surgery patients undergoing cardiopulmonary bypass (CPB). These patients often face increased risks of postoperative complications, such as worsening renal dysfunction, which can lead to extended ICU stays and increased mortality. "The GRADIENT Trial offers an invaluable opportunity to further explore renal support during cardiac surgery," said Dr. Evelio Rodriguez , a renowned heart surgeon at Ascension Saint Thomas in Nashville, TN , and the National Principal Investigator of the GRADIENT trial. "The JuxtaFlow device offers new hope for some of our most vulnerable patients." JuxtaFlow RAD is an innovative device designed to potentially improve kidney function during times of acute stress. By applying a gentle suction to the kidney's outlet, it aims to enhance blood filtration more efficiently. This groundbreaking approach was recognized with an FDA Breakthrough Device Designation in April. The GRADIENT study will be a prospective, multicenter, randomized, controlled, open-label trial that plans to enroll patients with renal insufficiency (eGFR 15-60 ml/min) undergoing elective or urgent cardiac surgery requiring CPB. The study seeks to evaluate the safety and effectiveness of the JuxtaFlow RAD to sustain or enhance renal function during and following CPB surgery. "Achieving Breakthrough Device Designation was instrumental in securing IDE approval," noted John Erbey , Chief Executive Officer at Roivios. "This initiative is the culmination of a decade of technological and clinical advancements in addressing kidney disease management challenges. Our ongoing dialogue with the FDA is paving the way for more effective management, empowering patients to thrive. We are eager to commence IDE enrollment and explore the JuxtaFlow RAD's potential to improve surgical outcomes and enhance patient quality of life." For more information about Roivios and the JuxtaFlow Renal Assist Device, please visit Roivios.com . About JuxtaFlow RAD The JuxtaFlow RAD is a pioneering investigational device set to transform kidney support therapy. Acknowledging the harmful effects of fluid accumulation and pressure on the kidneys, Roivios has advanced beyond traditional blood filtration methods that can further stress the kidneys. By applying mild, controlled negative pressure within the kidney's collecting system, the device has the potential to maintain and improve filtration and support recovery. This novel approach holds promise for a compelling value proposition by preserving kidney function and expediting patient recovery, ultimately reducing hospital stays and associated costs. Equipped with a proprietary specialized catheters and pump, the device optimizes kidney function during critical recovery periods, such as post-surgery. Currently, the JuxtaFlow RAD is under investigation and is not available for sale in any geography. About Roivios Roivios is a clinical-stage medical device company committed to pioneering solutions for kidney health. Our lead product, the JuxtaFlow Renal Assist Device (RAD), is designed to preserve kidney function and offer a proactive approach to managing kidney disease. We aim to demonstrate improved renal outcomes, potentially reducing the need for dialysis, and lowering healthcare costs. Holding proprietary patents in key kidney technologies, we aim to revolutionize kidney disease management. With plans to extend its application beyond kidney disease to various medical settings, Roivios is preparing for a transformative U.S. launch, aiming to redefine kidney disease management and improve patient quality of life. Discover more at roivios.com . This release contains forward-looking statements subject to risks and uncertainties. Actual results may differ significantly. Media Contact : Kelly Krueger , Krueger PR, kelly@kruegerpr.com View original content to download multimedia: https://www.prnewswire.com/news-releases/fda-grants-ide-approval-for-the-pivotal-trial-of-the-juxtaflow-renal-assist-device-rad-302336698.html SOURCE Roivios, ltd