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NSE: 40% of Nigeria’s Agric Output Lost to Post-harvest ActivitiesEven with access to blockbuster obesity drugs, some people don't lose weight Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Jonel Aleccia, The Associated Press Nov 23, 2024 6:10 AM Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message FILE - Donna Cooper holds up a dosage of Wegovy, a drug used for weight loss, at her home, March 1, 2024, in Front Royal, Va. (AP Photo/Amanda Andrade-Rhoades, File) Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content. Jonel Aleccia, The Associated Press See a typo/mistake? Have a story/tip? 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It’s a 10-year anniversary set to brighten communities across the country. Monuments across Canada, including the giant Winnipeg sign at The Forks and the Esplanade Riel, will be lit up yellow this week to celebrate 10 years of the #NoGoodWay Day campaign, a nationwide effort to build a more inclusive environment for Special Olympics athletes. “Special Olympics has given me the world,” said Camryn Grant, an athlete in Winnipeg. “It has provided me friendships and being able to play sports.” Spearheaded by Motionball athletes, the event is an anti-bullying campaign at its heart, educating people about the importance of inclusive language aimed to end casual and negative use of the “R-Word” in everyday conversations. “It really is hard when you see an athlete get bullied or have someone say something negative towards them,” said Grant. She says Motionball has had a significant impact on building a supportive community for Special Olympics athletes, and the campaign has played an important role in the work across all sports. “It makes everyone happy when they see everyone having fun,” she said. “When they don’t, it can take a negative impact on someone, and you can see athletes will shy away from sports.” The campaign is calling on the public to take a pledge to not use the “R-word” in everyday conversation, to educate others about the link between the R-word and bullying and for people to show their support for #NoGoodWay Day. Marina Lovell, the event director at Motionball Winnipeg, says the words we use can have a real effect on people. “We hold a lot of power with the words that we say,” said Lovell. “Hopefully we can use that for the good. So by changing the language, and stopping using that word, we hopefully can promote inclusivity and those living with an intellectual disability can feel more welcome.” Since the beginning of the campaign, Motionball says tens of thousands of Canadians have pledged their commitment to use inclusive language. “Obviously a lot of people have jumped on board and taken the pledge,” she said “We just want to get the word out; to stop using that word, and if they do hear it, to say something to someone.” To show support for Special Olympic athletes and the #NoGoodWay campaign, you can take the pledge on the .LAS VEGAS — Players Era Festival organizers have done what so many other have tried — bet their fortunes in this city that a big payoff is coming. Such bet are usually bad ones, which is why so many massive casino-resorts have been built on Las Vegas Boulevard. But it doesn't mean the organizers are wrong. They're counting on the minimum of $1 million in guaranteed name, image and likeness money that will go to each of the eight teams competing in the neutral-site tournament that begins Tuesday will create a precedent for other such events. EverWonder Studios CEO Ian Orefice, who co-founded Players with former AND1 CEO Seth Berger, compared this event to last year's inaugural NBA In-Season Tournament that played its semifinals and final in Las Vegas by saying it "did really well to reinvigorate the fan base at the beginning of the year." "We're excited that we're able to really change the paradigm in college basketball on the economics," Orefice said. "But for us, it's about the long term. How do we use the momentum that is launching with the 2024 Players Era Festival and be the catalyst not to change one event, but to change college basketball for the future." Orefice and Berger didn't disclose financial details, but said the event will come close to breaking even this year and that revenue is in eight figures. Orefice said the bulk of the revenue will come from relationships with MGM, TNT Sports and Publicis Sport & Entertainment as well as sponsors that will be announced later. Both organizers said they are so bullish on the tournament's prospects that they already are planning ahead. Money made from this year's event, Orefice said, goes right back into the company. "We're really in this for the long haul," Orefice said. "So we're not looking at it on a one-year basis." Rick Giles is president of the Gazelle Group, which also operates several similar events, including the College Basketball Invitational. He was skeptical the financial numbers would work. Giles said in addition to more than $8 million going to the players, there were other expenses such as the guarantees to the teams. He said he didn't know if the tournament would make up the difference with ticket sales, broadcast rights and sponsorship money. The top bowl of the MGM Grand Garden Arena will be curtained off. "The math is highly challenging," Giles said. "Attendance and ticket revenues are not going to come anywhere close to covering that. They haven't announced any sponsors that I'm aware of. So it all sort of rests with their media deal with Turner and how much capital they want to commit to it to get these players paid." David Carter, a University of Southern California adjunct professor who also runs the Sports Business Group consultancy, said even if the Players isn't a financial success this year, the question is whether there will be enough interest to move forward. "If there is bandwidth for another tournament and if the TV or the streaming ratings are going to be there and people are going to want to attend and companies are going to want to sponsor, then, yeah, it's probably going to work," Carter said. "But it may take them time to gain that traction." Both founders said they initially were met with skepticism about putting together such an event, especially from teams they were interested in inviting. Houston was the first school to commit, first offering an oral pledge early in the year and then signing a contract in April. That created momentum for others to join, and including the No. 6 Cougars, half the field is ranked. "We have the relationships to operate a great event," Berger said. "We had to get coaches over those hurdles, and once they knew that we were real, schools got on board really quickly." The founders worked with the NCAA to make sure the tournament abided by that organization's rules, so players must appear at ancillary events in order to receive NIL money. Strict pay for play is not allowed, though there are incentives for performance. The champion, for example, will receive $1.5 million in NIL money. Now the pressure is on to pull off the event and not create the kind of headlines that can dog it for years to come. "I think everybody in the marketplace is watching what's going to happen (this) week and, more importantly, what happens afterwards," Giles said. "Do the players get paid on a timely basis? And if they do, that means that Turner or somebody has paid way more than the market dictates? And the question will be: Can that continue?" CREIGHTON: P oint guard Steven Ashworth likely won’t play in the No. 21 Bluejays’ game against San Diego State in the Players Era Festival in Las Vegas. Ashworth sprained his right ankle late in a loss to Nebraska on Friday and coach Greg McDermott said afterward he didn’t know how long he would be out. Get local news delivered to your inbox!Super Clash: Kotoko coach Prosper Ogum counting on playersâ self-belief for victory against Hearts
Fallout's Walton Goggins Revealed Why He's 'Really Scared' To Play The Ghoul Again In Season 2, And I Totally Get ItFRISCO, Texas (AP) — A rare win as a double-digit underdog came just in time to let the Dallas Cowboys believe their playoff hopes aren't completely gone in 2024. Cooper Rush probably will need three more victories in a row filling in for the injured Dak Prescott for any postseason talk to be realistic. The thing is, the Cowboys (4-7) could be favored in two of those games, and already are by four points as an annual Thanksgiving Day host against the New York Giants (2-9) on Thursday, according to BetMGM. Not to mention the losing record at the moment for each of the next four opponents for the defending NFC East champions, playoff qualifiers each of the past three seasons. The Cowboys have a chance to make something of the improbable and chaotic 34-26 win at Washington that ended a five-game losing streak. “Behind the eight ball,” Micah Parsons said, the star pass rusher acknowledging the reality that Dallas hadn't done much yet. “Let’s see how we can handle adversity and see if we can make a playoff run. But we got a long way to go.” It was a start, though, powered in part by the best 55 minutes from the Dallas defense since the opener, when the Cowboys dismantled Cleveland and looked the part of a Super Bowl contender. The last five minutes for the Dallas defense against the Commanders looked a lot like most of the nine games after that 33-17 victory over the Browns. Which is to say not very good. Jayden Daniels easily drove Washington 69 yards to a touchdown before throwing an 86-yard scoring pass in the final seconds to Terry McLaurin, who weaved through five defenders when a tackle might have ended the game. The Cowboys kept a 27-26 lead thanks to Austin Seibert's second missed extra point, and withstood another blunder when Juanyeh Thomas returned an onside kick recovery for a TD rather than slide and leave one kneel-down from Rush to end the game. Dallas will have to remember it did hold a dynamic rookie quarterback's offense to 251 yards before the madness of the ending in the Cowboys' biggest upset victory since 2010 at the New York Giants. That one was too late to save the season. This one might not be. “We needed it,” embattled coach Mike McCarthy said. “It’s been frustrating, no doubt. We’ve acknowledged that. We’ve got another one right around the corner here, so we have to get some wins and get some momentum.” Rush ended a personal three-game losing streak with his best showing since the previous time he won as the replacement for Prescott, who is out for the season after surgery for a torn hamstring. The 117.6 passer rating was Rush's best as a starter, and the NFL's second-worst rushing attack played a solid complementary role with Rico Dowdle gaining 86 yards on 19 carries. KaVontae Turpin's electrifying 99-yard kickoff return did more than lift the Cowboys when it appeared an 11-point lead might get away in the final five minutes. It eased the worst day of special teams for Dallas since John Fassel took over that phase four years ago. Suddenly struggling kicker Brandon Aubrey had one field-goal attempt blocked and missed another. Bryan Anger had a punt blocked. For the second time in five games, Aubrey's attempt to bounce a kickoff in front of the return man backfired. The ball bounced outside the landing zone, putting the Commanders at the 40-yard line to start the second half and setting up the drive to the game's first touchdown. CB Josh Butler, whose NFL debut earlier this season came five years after the end of his college career, had 12 tackles, a sack and three pass breakups. The pass breakups were the most by an undrafted Dallas player since 1994. Rookie LT Tyler Guyton, who has had an up-and-down season with injuries and performance issues, was benched immediately after getting called for a false start in the fourth quarter. His replacement, Asim Richards, could be sidelined with a high ankle sprain that executive vice president of personnel Stephen Jones revealed on his radio show Monday. Veteran Chuma Edoga, who was the projected starter at Guyton's position before a preseason toe injury, was active but didn't play against the Commanders. He's awaiting his season debut. The status of perennial All-Pro RG Zack Martin (ankle/shoulder) and LG Tyler Smith (ankle/knee) will be a question on the short week after both sat against Washington. Stephen Jones indicated Smith could be available and said the same of WR Brandin Cooks, who hasn't played since Week 4 because of a knee issue. TE Jake Ferguson may miss at least a second week with a concussion. The short week might make it tough for CB Trevon Diggs (groin/knee) to return. 75% — Rush's completion rate, his best with at least 10 passes. He was 24 of 32 for 247 yards with two touchdowns and no interceptions. His other game with multiple TDs and no picks was a 25-10 victory over Washington two years ago, when he went 4-1 with Prescott sidelined by a broken thumb. There's some extra rest after the short week, with Cincinnati making a “Monday Night Football” visit on Dec. 9. The next road game is at Carolina on Dec. 15. AP NFL: https://apnews.com/hub/nfl
Conor McGregor faces fallout from civil case as career and fortune hang in balanceAbout 50 members of the Cedar Hill community turned up to a prayer vigil this evening in response to recent violent incidents in the area. The event at the Cedar Hill Salvation Army car park was organised by the Garden Ministry and partners. The call came about a week after two men were injured in a shooting in the Cedar Heights Lane area. Aged 53 and 38, they suffered multiple gunshot wounds, but their injuries were not life-threatening. Chaplain Santucci said: “This is primarily in response to the attempted murder, the attempt on life, Thursday past. “We can’t let our communities run away from us so I contacted key stakeholders. Here we have it. “I know that it takes more than just coming together. It takes some ongoing steps, this is just the first of many steps we would like to take to bring back a spirit of culture in our communities of which we can all be happy and not feel that we are threatened by anyone or anything. “If we don’t do it now, who is going to do it? We don’t have to wait for a stray bullet to take the life of anybody else. “The Government and law enforcement must play their part but the community must take responsibility as well. This is one of the things that we as a community can do.” Partners included The Salvation Army and its band which performed music throughout the vigil. Others included the New Testament Church of God, church leaders and other reputable persons within the community. Neville Tyrell, MP for constituency 26, was present as was Douglas De Couto, candidate for constituency 25. The recent shootings took place in constituency 27. Mr Tyrell said: “It is important that we have the community together. The issue is community based. It is sad that our young children are going the wrong way but at the same time they need guidance and this is something we should show as an example. “We are here to talk to them, some of them feel that we don’t want to speak to them, maybe we don’t speak their language all the time but at the same time we are still open to help them.” Dr De Couto said: “This neighbourhood and the whole parish has had quite a lot of violence over the last several years including recently right around the corner. I am glad to be here as one of the voices at this vigil. “I know that children are affected by this. Through my canvassing, I met a young girl in this neighbourhood and for six months she couldn’t sit in her own bedroom after there was a shooting around the corner. imagine that multiplied by all the families.” Lieutenant Amy Patrick of The Salvation Army said: “This island, our world, is fraught with darkness and negativity but that doesn't define who we are. We are not alone, there is hope and there is light.“ Others shared words of reflection including Ras Mykall, who shared social commentary in the form of a poem, and Bishop Rudolph Ebbin who shared a prayer. Police have urged witnesses to come forward, particularly anyone who may have seen two people speeding on a motorcycle immediately after the shooting, which took place at about 9.10pm on November 21.MarketAxess Holdings Inc. stock underperforms Tuesday when compared to competitors
TRAI makes it mandatory for telecom service providers to display coverage mapsEnanta Pharmaceuticals' chief product strategy officer sells $18,400 in stock
GAINESBORO, Tenn. (WTVF) — As word spread across Jackson County, a gathering of friends quickly grew into an impromptu town hall. One woman, with her freshly coiffed hair, rushed over after hearing about the gathering at the local beauty salon, as did the owners of two restaurants and the coffee shop that all sit on the east side of the Gainesboro town square. One by one, local townspeople — about 50 in all — seemingly appeared out of nowhere from the quiet streets of Gainesboro and quickly ducked into the events center that sits just across the street from the historic Jackson County Courthouse. FULL REPORT: Watch NC5 at 6 p.m. Some just came with questions — others, with deep concerns. "We don't want one news story to portray something of Jackson County that we're not," said Kara Smith, whose husband Beau had spread the word that we were coming to town. It followed NewsChannel 5’s revelations about the white Christian nationalists — led by podcasters Andrew Isker and C.Jay Engel — now setting their sights on Jackson County, hoping to turn this quaint community of just over 12,000 people into a political haven for others just like themselves. Jackson County is located about 90 minutes northeast of Nashville. "We're building a town, right? We're building a community there,” Isker said during a July podcast when he and Engel announced their move to Tennessee. Yet, for the people who already have a community here, the news took them by surprise. "Did anyone have any sense about these people prior to this story?" I asked. A loud chorus of local residents responded in unison, “No, no." Among those we met, some had deep roots. "My family has been here for seven generations," said Mark Dudney, a public historian with an agency that serves the Upper Cumberland region of Tennessee. Others were drawn here by the openness of the people they now call neighbors. “I'm a ‘mover-inner.’ I think that's what you all call people who move in from other areas,” said Diane Murphy, glancing around the room with a smile. "This town is such a loving group of people. I've been accepted, even though I came in from outside." And we were there to listen. "What has this story done to this community's sense of well-being?" I asked. "I think mainly people are scared," answered Murphy, who is vice chair of the local Republican Party. I had explained to the crowd that I had used the online story to provide documentation for every remark attributed to Isker and Engel, Murphy added: "I listened to the podcasts. I did research on what you mentioned," Murphy added. "It scares me that they are very clear about taking over." Developers with right-wing ties have purchased hundreds of acres of land in the area, trying to recruit other like-minded people to join Isker and Engel in relocating to Gainesboro. In a video posted online by one of the developers, Isker talked about the ability of those people to get their way in a small community. "You could exercise far, far more political power – even with a few hundred or a few thousand people – than you can on your own, widely dispersed across the entire country,” the right-wing Minnesota pastor said. I asked the Jackson County residents, "When you hear them talking about coming here to build a town, to build a community, what's your reaction?" Diana Mandli quickly chimed in. "I would love to speak to that. That makes me mad," she said. Mandli co-owns a local restaurant, the Bull and Thistle, and she sees a community remaking itself without the help of strangers from out of state who don't understand what Jackson County already has. "People from all different walks of life, genealogies, nationalities, race — you name it — we have got a melting pot right here in this small town, all working together to make this town come back to life,” she explained. So, I wanted to know, “What is it you're afraid of losing?" "I don't want to lose what we already have — the sense of community." Mark Dudney, the public historian, agreed. “It is a very welcoming community, but I think they kinda came in under the radar and want to recreate it in their own image," he said. On election night, the podcasters monitored the results of the 2024 presidential election during a nearly nine-hour show from Gainesboro. The real estate developer behind the project, Josh Abbotoy, provided live reports from a watch party he had hosted for local Republicans at the same events center. One of their podcast buddies also set up an account on X, formerly Twitter, that claimed to represent the views of the local Republican Party. Jackson County Republican Party chair Beau Smith was surprised when NewsChannel 5 Investigates first told him about the X account. "It said it was the official account of the Jackson County GOP." "But it was not," said Smith, who immediately insisted that the podcaster remove the claim that the account was endorsed by the local party. We also showed him where Engel had tweeted that "the best way forward" for Christian nationalists "is to take over local level outlets of the Republican Party." "So that's not going to happen especially now due to your reporting,” Smith said. “We're thankful for that, and knowing these people are in our community is a big deal." Still, not everyone is so concerned. The administrator of a local Facebook group lashed out at those who were also upset that a white supremacist group, the Asatru Folk Assembly, had bought property in Jackson County in December 2022. “I think you guys just don’t like outsiders,” Mickie Davis posted. “Just live and let live.” Late Friday, Engel appeared on a YouTube program run by a local minister to try to quell some of the public backlash following NewsChannel 5’s report. As the host took calls from local residents, Engel was asked about the podcasters’ claims that they are coming to Jackson County to “start a town.” Engel described it as being an “analogous” statement. “Our plan is to assimilate into the culture of the area and to participate in making Gainesboro a better place to live, to the extent that we are welcomed to,” he said. Back inside the events center, I asked the group, "Have these Christian nationalist podcasters, these developers tried to have a meeting like this, to sit down and answer your questions?" “No,” they again responded in unison. One woman called out from across the room, "They're a wolf in sheep's clothing." But what really concerned these Jackson County residents — some who were reluctant for their faces to be on camera — are the podcasters' views that the Civil Rights movement was a mistake, that foreigners who have become U.S. citizens still don't belong in America. I asked, "What is it that you would like for these people coming in from out of state to know? What message would you have for these people?" "This town is not for them," said local business owner Barry Naff. Another woman called out, "Bigotry is not going to work." "No, it's not going to work," Naff agreed. Yet another woman chimed in from off camera, "We are not that community, and we don't want to be a part of a racial hate community." Then, Isker and Engel’s views on women are discussed. On social media, Engel had posted that he "detest(s) the specific impact of college-educated White women on the culture of the world" he sees around him. That comment had brought a spirited response on Facebook. "The White women on Facebook that you are referring to, they are probably the scariest thing these guys are going to have to deal with now," Mark Dudney said, drawing laughter from the crowd. Over and over, the townspeople made clear that, if the Christian nationalists think Gainesboro and Jackson County is a place where people all think like them, they don't know Jackson County. "These people's views do not represent our community,” said lifelong resident Nan Coons. "And if they think they are going to come in here and take over and force their views on everybody else, they are going to have a fight on their hands." —————————— Do you have information that would help me with my investigation? Send me your tips: phil.williams@newschannel5.com RELATED STORIES: June 24, 2024: Data compiled by watchdog groups suggests that neo-Nazis, white supremacists, and other hate groups have targeted the Volunteer State with racist flyers at an alarming rate in the past year, signaling a more brazen and calculated focus on the state. The statistics are alarming. July 19, 2024: Standing on what is now the Diane Nash Plaza — named after the civil rights legend who came here to confront a Nashville mayor and a community's racism — I decided to confront the hate that has once again reared its ugly head. Click here to watch my exchange. August 20, 2024: He warned me there would be consequences if I failed to comply with his demands to air a white-supremacist video. Then, nothing happened. And now that man faces his own consequences. Read more about Kai Liam Nix. September 16, 2024: Millersville, Tennessee, is gaining national attention for an approach to governing that democracy advocates fear. Here, conspiracy theorists carry guns and badges, using their police powers to explore notions that are sometimes completely divorced from reality. You can find a series of stories here. Related videos, stories: Hate Comes to Main Street
