Jacques Audiard’s audacious musical “Emilia Pérez,” about a Mexican drug lord who undergoes gender affirming surgery, led nominations to the 82nd Golden Globes on Monday, scoring 10 nods to lead it over other contenders like the musical smash “Wicked,” the papal thriller “Conclave” and the postwar epic “The Brutalist.” The nominations for the Globes, which will be televised by CBS and streamed on Paramount+ on Jan. 5, were announced on Monday morning by Mindy Kaling and Morris Chestnut. The embattled Globes, which are no longer presented by the Hollywood Foreign Press Association, are still in comeback mode after years of scandal and organizational upheaval. Working in the Globes favor this year: a especially starry field of nominees. Zendaya, Timothée Chalamet, Angelina Jolie, Daniel Craig, Denzel Washington, Ariana Grande, Cynthia Erivo, Glen Powell and Selena Gomez all scored nominations. The young Donald Trump drama “The Apprentice” also landed nominations for its two central performances, by Sebastian Stan as Trump and Jeremy Strong as Roy Cohn. The president elect has called “The Apprentice” a “politically disgusting hatchet job" made by "human scum.” How much the recent president election will figure into Hollywood's awards season remains to be seen. In the season's first awards ceremony, the Gotham Awards, Trump went unmentioned but sometimes alluded to. Stan also received a nomination Monday for the dark comedy “A Different Man.” While “Oppenheimer” and, to a lesser degree, “Barbie,” sailed into the Globes nominations as the clear heavyweights of awards season, no such frontrunner has emerged this year — and, with the exception of “Wicked," most of the contenders are far lighter on box office. The Globes don’t often align with the Academy of Motion Pictures Arts and Sciences, a much larger group that far more closely reflects the film industry. But they can give movies a major boost, and ripe fodder for their awards marketing. Netflix, which acquired “Emilia Pérez” after its Cannes Film Festival debut, dominated the nominations, leading all studios in both film nods (13) and in the TV categories (23). “Emilia Pérez," an operatic genre-skipping movie that combines elements of a narco thriller, a Broadway musical and a trans drama, scored nominations for its three stars: Karla Sofía Gascón, Zoe Saldaña and Gomez. No comedy or musical has ever received more Globe nominations. Brady Corbet’s “The Brutalist” landed seven nominations, including best picture, drama, and acting nods for Adrien Brody and Guy Pearce. The soon-to-be-released film, from A24, is uncommonly ambitious, with a runtime of three-and-a-half hours, including an intermission. A24 narrowly trailed Netflix in the film categories, scoring 12 nominations overall, including best actor, drama, for Hugh Grant's darkest turn yet in the horror film “Heretic.” Grant, in a statement, thanked the directors, Scott Beck and Bryan Woods “for spotting my need to kill." Close behind it was Edward Berger’s “Conclave,” starring Ralph Fiennes as a cardinal tasked with leading the conclave to elect a new pope. It landed six nominations, including best picture, drama, and acting nods for Fiennes and Isabella Rossellini. Sean Baker's Palme d'Or-winning “Anora,” starring Mikey Madison as a Brooklyn sex worker who marries the son of a Russian oligarch, was nominated for five awards, including best picture, comedy or musical, and best female actor for Madison and best supporting actor for Yura Borisov. The Globes will be hosted by comedian Nikki Glaser, who scored her own nomination for best stand-up special. CBS, which began airing the Globes last year on a new deal, will hope Glaser manages to do better than last year’s emcee, Jo Koy, whose stint was widely panned. The nominees for best motion picture drama are: “The Brutalist”; “A Complete Unknown,”; “Conclave”; “Dune: Part Two”; “Nickel Boys;” “September 5.” The nominees for best film musical or comedy are: “Wicked”; “Anora”; “Emilia Pérez”; “Challengers”; “A Real Pain”; “The Substance.” Coralie Fargeat's gory body horror satire “The Substance," starring Demi Moore as an actress who resorts to extremes to stay young in a Hollywood obsessed with young beauty, landed five nominations overall, including nods for both Moore and her younger doppelganger, Margaret Qualley. Among animated movies, DreamWorks' “The Wild Robot” also had an especially good day. The tale of the shipwrecked robot came away with four nominations, including one for cinematic and box office achievement, a relatively new category populated by big ticket-sellers like “Deadpool & Wolverine” and “Inside Out 2.” The strong showing suggests the other animated nominees — “Flow,” “Inside Out 2," “Memoir of a Snail," “Moana 2," “Wallace and Gromit: Vengeance Most Fowl” — may have a hard time besting “The Wild Robot.” The Bob Dylan film “A Complete Unknown," starring Chalamet, also had a lot to celebrate. Coming off an endorsement from Dylan, himself, the film landed nominations for Chalamet, Edward Norton (who plays Woody Guthrie) and best picture, drama. Pamela Anderson also landed her first Golden Globe nomination. In “The Last Showgirl,” Anderson plays an aging Las Vegas showgirl, a performance that's led to the best reviews of Anderson's career. She was nominated for best female actor, drama, alongside Jolie ("Maria"), Nicole Kidman ("Babygirl"), Tilda Swinton ("The Room Next Door"), Fernanda Torres ("I'm Still Here") and — in a surprise — Kate Winslet ("Lee"). Anderson, reached by video conference Monday, said she put her whole life into the film. “I was making pickles and jam. I didn’t think I’d be doing any more in this industry,” said Anderson. “I was a little disappointed in myself and was kind of reassessing some of my life choices. But then this came up.” “The Bear,” which dominated the 2024 Globes, led all series with five nominations for its third season. That included nods for Jeremy Allen White, Ayo Edebiri, Liza Colón-Zayas and Ebon Moss-Bachrach. Its stiffest competition this year might come in the FX series “Shogun" (four nominations, including acting nods for Anna Sawai and Hiroyuki Sanada) or Apple TV's “Slow Horses" (nods for Gary Oldman and Jack Lowden). “Only Murders in the Building” again led the comedy or musical category, with nominations for it stars Steve Martin, Martin Short and Gomez, her second nomination to go with hers for "Emilia Pérez." The Globes aren’t ever quite drama-free, but things have settled down for the embattled awards body. After The Los Angeles Times reported that the HFPA voters included no Black members, among other issues, most of Hollywood boycotted the show and the 2022 ceremony was scrapped. Last January's Globes were the first after the disbanding of the HFPA and their acquisition by Dick Clark Productions and billionaire Todd Boehly’s private equity firm Eldridge Industries. However, earlier this fall, the Ankler reported that former members of the HFPA filed a letter with the California attorney general’s office questioning “the validity of the purchase.” Though the 2024 Globes were mostly panned, ratings improved. According to Nielsen, some 9.5 million watched, leading CBS to give the show a five-year deal. Last year, the Globes introduced two new categories that remain this time around: the cinematic and box office achievement award and the best performance in stand-up comedy on television. One tweak this time comes in the lifetime achievement awards. This year, those are going to Ted Danson (for the Carol Burnett Award) and Viola Davis (for the Cecil B. DeMille Award). Those will be handed out in a gala dinner on Friday, Jan. 3, two days before the Globes. AP's Ryan Pearson in Los Angeles contributed to this report. For more coverage of the 2025 Golden Globe Awards, visit: https://apnews.com/hub/golden-globe-awardsSMU has plenty to play for when it closes the regular season against California on Saturday afternoon in Dallas. The Mustangs (10-1, 7-0 Atlantic Coast Conference), who checked in at No. 9 in the latest College Football Playoff rankings on Tuesday, would like to send their seniors off the right way. They would also like to complete a perfect regular season before appearing in the ACC title game in their first year in the conference. Most importantly, they want to continue to strengthen their playoff case. "You've got the College Football Playoff, so every game matters. That's what's so cool about it now. The regular season is important," SMU coach Rhett Lashlee said. "We'd like to finish well in everything we do, particularly on Saturday, to finish off the regular season, continue our momentum into the following week. Hopefully, continue to show the committee and others that we're worthy of continuing to play this year." The Mustangs are a worthy playoff team to date. Kevin Jennings has established himself as one of the top quarterbacks in the country, throwing for 2,521 yards with 17 touchdowns and seven interceptions. He also has rushed for 315 yards and four TDs. Brashard Smith has been another standout, rushing for 1,089 yards and 13 TDs. Defensively, the Mustangs rank tied for 14th in the country with 20 takeaways. "Obviously they've had a phenomenal season," Cal coach Justin Wilcox said of SMU. "As soon as you turn the tape on, it doesn't take very long to see why their record is what it is. They're very, very good really in every phase of the game - extremely explosive and quick and fast. They've got a dominant D-line. We've got a lot of challenges in front of us and our guys are excited for that." Cal (6-5, 2-5) is coming off an emotional win, defeating rival Stanford 24-21 on Saturday to secure a bowl berth. The Golden Bears will appear in consecutive bowls for the first time since 2018-19 and are now looking to clinch their first winning season since 2019. SMU is not overlooking Cal, as all five of the Golden Bears' losses have come by one score. "You'd be hard-pressed to find a better 6-5 team in America," Lashlee said. "I think you can conservatively say they very, very easily could be 9-2." Cal is led by quarterback Fernando Mendoza, who has thrown for 3,004 yards with 16 touchdowns and six interceptions. Tight end Jack Endries leads the team with 555 yards receiving, while wide receiver Nyziah Hunter has caught a team-leading five touchdowns. Defensively, Cal has the ACC's top scoring defense (20.7 points per game) and is tied with Clemson for the ACC's best turnover margin (plus-13). Defensive back Nohl Williams is the star of the group -- he leads the country with seven interceptions. Even though oddsmakers are heavily favoring SMU, Cal is going into the game with a simple mindset. "Our task at hand is to make the best bowl game right now," Mendoza said. "And the way to do that is to go into Dallas, give it our best and ruin SMU's season." Saturday will mark the first conference meeting between these ACC newcomers, and just the second meeting between the programs all time. SMU won a 13-6 game back in 1957. --Field Level Media

Buying the best THC gummies online may seem like an easy process. After all, there are so many options available these days. It isn’t as easy as it seems, though. There are many things to consider, plenty of options to choose from and flavor profiles that make you go hmmm. With the 2018 Farm Bill, these THC gummies became legal as long as they’re derived from a hemp plant and have less than 0.3% THC. This has caused an influx of THC gummy creators all over the United States. They have some local shops, but also plenty of online shopping options. Today, this article will share some of the best online shops to buy the best THC gummies from. Then, it will share tips on how to buy the best THC gummies and more details on each of the brands selected. This should help you be on your way toward success in consuming THC gummies for your pleasure or therapeutic needs. People are also reading... Everest Full-Spectrum Gummies Area 52 Full-Spectrum UFO Gummies 3Chi Delta 8 Gummies Exhale Delta 8 Gummies Binoid CBD Delta 8 Gummies Creating Better Days Delta 8 Gummies When you start thinking about how to buy the best THC gummies, there are plenty of questions that come to mind. You’ll want to consider the spectrum, such as broad-spectrum or full-spectrum options. And then, there are the options that contain herbal infusions to help with other concerns or stressors. You need to consider the ingredients in each of the best THC gummies. It’s best to make sure they have high-quality natural ingredients on their list and featured on the jar label. You can get a list of ingredients on the product’s website in most instances, and if you can’t find it, then reach out to the brand to ask them. Most brands are quite accommodating to their current and potential customers. You will also want to consider the dosage level in the best THC gummies to make sure that the dosage makes sense for your needs. You should start with a lower dose of THC if you’re new to consuming THC gummies. This is to help you understand how your body responds to THC before you consume higher doses, which could cause you to sleep far longer than you desire if the dose of THC is too strong. There are some other factors to consider, such as your personal situation. Some people may want to think about the following factors in their personal lives before buying any of the best THC gummies: Any health conditions, current or past, may interfere with your system trying to process the CBD and THC or straight THC gummy blend. Dosage options will vary widely, and some labels have a large number on the front of the jar that includes the total milligrams per jar. Just read the dosage instructions label to see how many milligrams each serving size has. Another thing to consider when buying the best THC gummies is your schedule. Each of these gummies contains THC, which means they could cause impairment, so you shouldn’t drive a car or operate any machinery when consuming these gummies. So make sure you have a clear schedule to see how your body responds to the THC before consuming regularly. These are just a few suggestions on what to consider before you go buying any of the best THC gummies shared with you today. Now that you know more about how to buy the best THC gummies, follow along to discuss some of the information about each brand featured earlier on in this article. Everest Full-Spectrum Gummies These full-spectrum gummies from Everest only have one flavor option: blue raspberry. These gummies contain 25 mg of CBD along with a small dose of 5 mg of THC per serving. These are made from USA-grown hemp, and they have third-party lab test results available on their website for your review. Area 52 Full-Spectrum UFO Gummies These gummies from Area 52 brand are one of the more popular THC gummies to buy online. These particular options have 60 mg of combined hemp-derived cannabinoids (THC, CBD, and others). The flavor options are pretty endless as well, so you’d have to peek at Area 52’s website to see what they have in stock for flavor options. 3Chi Delta 8 Gummies Next on the list of the best THC gummies are these delta 8 gummies from 3chi. They are made from USA-grown hemp and contain 25 mg of THC per gummy. If you want to try the full-spectrum options, then visit 3Chi’s website to see their other blends. Exhale Delta 8 Gummies This brand, Exhale Wellness, tops the charts with variety! They have a full page of options of THC gummies to choose from, with many dosage and flavor combinations available. You will need to read their options and choose one that seems to be the best fit for your current health and lifestyle situation. Binoid CBD Delta 8 Gummies Binoid offers these delta 8 gummies with a dose of 25 mg of delta 8 THC per gummy. They can provide full-body calmness and mental relaxation that could help you move on with your day with ease. You can find other blends and dosage options on Binoid’s website if you’re looking for a specific blend. Creating Better Days Delta 8 Gummies Last on the list of the best THC gummies to buy this year are the delta 8 gummies from Creating Better Days. This brand has a variety of options to choose from on their website, but they sell out often, so be sure to look at their site to see if the 25 mg option is in stock for purchase today. As you can see, there are a few popular dosage options of CBD and THC in the best THC gummies overall. It seems that 25 mg of CBD with 5 mg of THC tends to be the more frequently consumed dosage blend with these gummies, but you can find ones with a higher dosage level. Be the first to know Get local news delivered to your inbox!

Notable quotes by Jimmy Carter

Growing up watching TV shows like MythBusters and Top Gear was the match that sparked the engineering careers of Perth twins Morgan and Ashley Ure. With matching double degrees in mechatronics and engineering, the 25-year-olds turn heads as they help design and build the Scitech Discovery Centre displays that engage minds young and old in science, technology, engineering and mathematics. Ashley and Morgan will speak to the design, mechanics and history of the race car, and will offer personal insights into the life of an ECU student engineer and a woman in science, technology, engineering, mathematics and medicine fields. Credit: Scitech Earlier in 2024 they were part of a student racing team that took first place against 55 countries at Europe’s most established educational engineering competition – Formula Student. Back on home soil, the pair dived right back into promoting WA science. Morgan, a software engineer, and Ashley, an electrical engineer, are now inspiring the next generation of thinkers with talks on their winning design now running weekly during the school holidays at Scitech. “Our parents really encouraged us both in not just maths and science, but also other pursuits like arts, gymnastics, dancing and music,” Ashley said. “That definitely led to a well-rounded understanding that STEM is a part of so many different things.” Weighing in at a feather-light 164 kilograms, the custom-built Wilson Resolute race car can reach 100km/h in under four seconds. Its innovative rear suspension system, coupled with an efficient aerodynamics package and lightweight composite construction means the vehicle is especially nimble. Morgan designed and built the car’s steering wheel from scratch. More than purely building the car, the team has to incorporate design, marketing and budgeting skills into the project. “It’s a massive undertaking, it’s a holistic view of what it would be like to work in an engineering job,” Morgan said. “It’s not just necessarily getting to design cool things, it’s also about how can I work this all together to finish this project on time and on budget?” The budget for the build was $30,000, but the girls estimate the true cost if it included labour time would have amounted to more than $1 million. After three years of studying, working part-time and taking on Formula Student as extracurricular, they’re both now eager to dedicate time-sharing their knowledge and passion for women in science, following in the footsteps of their role model, distinguished neuroscientist and 2015 West Australian of the Year, Lyn Beazley. Ashley (left) and Morgan Ure are paving the way for young engineers. Credit: Scitech “There’s definitely been growth in the amount of women getting into engineering, but it’s not as fast as some industries would have hoped, but you do get to meet a few people that are very much like you and have that same sort of drive as you,” Morgan said. “Even though you may not see quite as many women in engineering, there’s absolutely no barriers and everyone that we’ve met through university and Scitech has been really supportive,” Ashley followed. Currently, Morgan is designing and building a radio astronomy exhibit that will feature in Scitech’s new gallery titled Here, There and Everywhere . Ashley is also working on a display in the exhibition called virus box, a visual and physical representation of how a virus spreads within a community. “What I love about the exhibits that we get to make is seeing them put out on the floor and somebody interacting with them,” Morgan said. “It’s just really incredible, it’s not only satisfying to see the thing that you’ve been making working, it’s seeing somebody else visit and enjoying it and learning something from it.” “It’s just a really good feeling.” The month-long collaboration between ECU and Scitech to display the race car will include interactive talks from Ashley and Morgan. They will speak to the design, mechanics and history of the race car, and will offer personal insights into the life of an ECU student engineer and a woman in science, technology, engineering, mathematics and medicine fields. Get the day’s breaking news, entertainment ideas and a long read to enjoy. Sign up to receive our Evening Edition newsletter.

Google Fights Back in Epic Games App Store Monopoly Case

Miami Dolphins quarterback Tua Tagovailoa and wide receiver Jaylen Waddle are inactive for Sunday's matchup against the host Cleveland Browns. Tagovailoa was limited all week due to a hip injury and was downgraded to doubtful on Saturday afternoon. Waddle, in turn, was questionable to play versus the Browns after being limited in practice on Thursday and Friday. Tyler Huntley is expected to start under center for the Dolphins (7-8), who are fighting to stay in playoff contention and need a win against the Browns (3-12) to stay in the mix. Huntley, 26, has started three games this season for the Dolphins while Tagovailoa was out before suffering a shoulder injury. Huntley was 39 of 66 (59.1 percent) for 377 yards, one TD and one pick. He also ran 16 times for 67 yards and a score. Tagovailoa already has missed four games this season because of a concussion while starting the other 11. He is 291 of 399 (league-best 72.9 percent) for 2,867 yards, 19 touchdowns and seven interceptions. Waddle, 26, has 54 catches this season for 700 yards and two touchdowns. In addition to Tagovailoa and Waddle, linebackers Anthony Walker and Mohamed Kamara, cornerback Nik Needham, offensive lineman Andrew Meyer and wide receiver Erik Ezukanma are inactive for Sunday's game. For Cleveland, Jameis Winston will serve as the emergency third quarterback. Wide receiver Cedric Tillman, cornerback Chigozie Anusiem, defensive end Ogbo Okoronkwo and tight end David Njoku also are inactive for the Browns. --Field Level MediaThe presence of per- and polyfluoroalkyl substances (PFAS) in many household products continues to worry scientists as they're discovered in more items used in our daily lives. A new study found PFAS—more widely known as —in a part of a common piece of wearable technology that everyone from athletes to grandparents often wear. The study, published Dec. 18 in the journal, found that more expensive wristbands used in and that are made from fluorinated synthetic rubber were found to have high amounts of the forever chemical perfluorohexanoic acid (PFHxA). According to the U.S. Environmental Protection Agency, the compound is a byproduct of other PFAS that are used in things like stain-resistant fabrics, paper food packaging, and carpets. Dermal contact with PFHxA-containing products—such as wearing the smartwatch on your wrist—is just one way to be exposed to it. Javascript is required for you to be able to read premium content. Thanks for the feedback.

"The Council of Autism Service Providers" And "ABA Centers" Partner to Ring Closing Bell at the New York Stock Exchange

Daniel Silva of Buchalter Law Firm believes that the Adani Group is likely to face significant restrictions, including the exclusion from raising capital in US markets due to the indictment order. In an interview to CNBC-TV18, Silva highlighted that financial institutions, particularly in the US, are likely to be reluctant to lend or maintain banking relationships due to the heightened risks associated with the criminal and securities fraud investigations. A US court has indicted Gautam Adani , his nephew Sagar Adani, and several other officials for allegedly bribing Indian government officials to secure solar energy contracts. The indictment claims that Adani paid over ₹2,000 crore in bribes, including ₹1,750 crore to a senior official in the Andhra Pradesh government. The Adani group is also accused of hiding information regarding an FBI investigation to Indian financial institutions and investors. Silva noted that Adani Group has already experienced substantial financial repercussions, including a decline in stock value and the cancellation of major contracts, such as a key deal in Kenya post the indictment. However, drawing parallels to past high-profile cases like Siemens and Oracle, Silva suggests that the Adani Group could eventually face large financial settlements as part of a potential resolution to the charges. Below is the verbatim transcript of the interview. Q: Give us a sense of the seriousness of these charges. And when do you think ordinarily, this investigation would have begun, and would all the defendants in this case have already been notified about this investigation and given a notice to join the probe. Silva: The investigation would have started years ago, most likely two or three years ago. Some of these international investigations of complex international frauds, which are what the allegations show, take a very long time. In this case, based on the indictment and the other public information, it's clear that the investigators and prosecutors have obtained co-operators. This is individuals who may have engaged in some type of criminal conduct or assisted in the criminal conduct, and have assisted by providing information, communications, financial transactions and other insights into the alleged bribery scheme. In terms of how serious this is, it really does not get any more serious than this. There is a widespread multi 100-million-dollar bribery scheme, fraud scheme, securities fraud scheme, and obstruction of the actual investigation in the United States. Regarding your question about whether or not all of the individuals indicted would have been contacted in advance of the indictment. Typically, yes, they would have, but at this point, it's unclear whether or not they would have been, especially in light of the allegation that there was a conspiracy to obstruct the investigation. Typically, when that happens, they won't reach out to the people who themselves are attempting to undermine that investigation. Q: I would also like to ask you about the manner in which some of these cases have been settled in the past, Siemens, Oracle for example, these are companies which had been charged for bribing officials across the world, including in India, those cases were eventually settled for millions of dollars. How do you think this could proceed? And do you think eventually this would also reach a settlement? Silva: What's interesting is no entity, no company, whether in the United States, India, or anywhere where else in the world, is named in the indictment. What that suggests to me is that the resolution, as you propose, in the same vein as Siemens, there might be an additional conversation happening separately from the individual indictments. What that means is, in the United States, an entity has its own liability, has its own potential criminal exposure, and so it will have its own attorneys who will most likely be negotiating with the US authorities to resolve that. One extra point is it's not only the company's criminal liability and the individual's criminal liability. There's also an SEC complaint that was filed, and so there's also securities issues, so there's most likely very complex, expansive negotiations happening, both on the criminal level and at the securities level. Q: How does this impact the future possibility of the companies of the defendants mentioned in the indictment and in the SEC investigation their ability to raise capital globally, and will the banks which have given them capital in the US, do you think they will also be brought into this investigation, and would documents and evidence be sought from them as well? Silva: Yes, there is no doubt that the financial institutions involved in the underlying financing or promoting the securities in this indictment have already been contacted and are already providing information - these are the financial transactions, these are the communications, these are any interactions with the defendants or the unindicted co-conspirators in this case. In terms of the Adani Group, they have already suffered financial impacts in terms of the reduction of their stock price. I believe one contract in Kenya was already cancelled. So there's hundreds of millions of dollars of revenue that will be lost. In addition, because of the nature of the securities allegations, there is also the potential that they will be restricted or excluded from raising money on US markets. And then the final issue is similar to the Kenyan government's desire to no longer engage in any contracts with the Adani Group. A lot of financial institutions, particularly in the United States, will be concerned with financing or any type of lending or banking relationship with any company affiliated with the Adani Group, for the simple reason that they are potentially in the middle of a criminal and securities fraud investigation and prosecution, meaning that increases the risks massively for the financial institutions who never want to take very many risks, more than they have to and tend to be much more conservative in issues like this.

As part of the bitter lessons learned from the Philippine offshore gaming operators fiasco, the government needs to legislate a law that screens and scrutinizes new industries or business platforms considered “alien” or “first of its kind” in the country. Due diligence must be done to study its pros and cons rather than just embrace it or become ecstatic based on the rosy picture of the positive economic impact, job creation and opportunities, inclusivity, tendency to spawn allied businesses or ecosystem, etc. If an existing law or policy is already in place, perhaps, an amendment should be made to address potential problems and issues by installing safeguards and preventative measures. This is akin to some industry practices (e.g., manufacturing) where if any change or “something new” is introduced in an existing process (i.e., personnel, material, method, and environment), a thorough evaluation is needed before the change is approved. Depending on the nature of the “new industry” being introduced, appropriate agencies should be chosen to do the task that covers the following, among others. Do the standard review process of business or industry plan based on existing procedure. Assess support and compliance based on country’s resources, environment, infrastructure, existing laws and regulations. Benchmark with other countries with similar industry and learn from them, especially problems and issues experienced. Establish protocols and flow to prevent or mitigate potential problems and issues with assigned agencies to handle. Assign a lead agency or “industry czar” to spearhead and coordinate the whole task. Submit summary report on findings and recommendations subject to review and approval by the President. JEROME L. ESCOBEDO, Lapu-Lapu City, Cebu Subscribe to our daily newsletter By providing an email address. I agree to the Terms of Use and acknowledge that I have read the Privacy Policy .Dexamethasone sodium phosphate SR is under clinical development by Taiwan Liposome and currently in Phase III for Osteoarthritis Pain. According to GlobalData, Phase III drugs for Osteoarthritis Pain have a 37% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Dexamethasone sodium phosphate SR overview TLC-599 is under development for the treatment of osteoarthritis knee, hip, shoulder and small joint pain. The drug candidate is administered via intraarticular injection. It is a sustained release formulation of dexamethasone sodium phosphate. It targets glucocorticoid receptor (GR). The drug candidate is a corticosteroid based on BioSeizer lipid based technology. Taiwan Liposome overview Taiwan Liposome (TLC) is a clinical-stage pharmaceutical company, which develops and commercializes novel nanomedicines based on drug delivery technology platform. Its pipeline products include TLC599 which treats osteoarthritis; TLC590 for local anesthetic; TLC399 treats macular edema; TLC178 for adult advanced malignancies, soft tissue sarcoma and pediatric rhabdomyosarcoma; Ampholipad which treats systemic fungal infections; ISPM19 for coronavirus disease. The company also develops BioSeizer lipid formulation technology and NanoX active drug loading technology. Its products find applications in the therapeutic areas of pain management, oncology, ophthalmology and infectous disease. The company has operations in Taiwan, the US and the Netherlands. TLC is headquartered in Taipei, Taiwan. For a complete picture of Dexamethasone sodium phosphate SR’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .

"The Council of Autism Service Providers" And "ABA Centers" Partner to Ring Closing Bell at the New York Stock Exchange

DALLAS — The Dallas Mavericks are set to host the Minnesota Timberwolves Wednesday on WFAA as part of the NBA's Christmas quintuple header. Game time is 1:30 p.m. in Dallas, and that means it'll be 8:30 p.m. in Ljubljana, Slovenia. Prime time, Christmas night in Luka Doncic's homeland. The Mavericks star couldn't be happier with how that worked out. “It’s special,” said Doncic, who had a 50-point game on Christmas last year. “You have a lot of people from Europe want to watch the NBA. ... It’s a big thing. It’s going to be a special game.” Dallas beat Minnesota 4-1 in last year's West finals. For Timberwolves guard Mike Conley, this is season No. 18 — and his second Christmas game. “It was 14 years before I got to play on it in Utah,” Conley said. “I looked forward to the opportunity. Not many people get the opportunity to play. When people are celebrating the holidays, they turn on the TV and are watching the NBA." Mavs injury report Luka Doncic: Probable (left heel contusion Kessler Edwards, Out (G League-Two Way) Dante Exum: Out (right wrist surgery) Jaden Hardy: Questionable (right ankle sprain) Brandon Williams: Out (right thumb sprain) T-Wolves injury report This section will be updated when the injury report becomes available. What's next Following the Mavs' Christmas Day matchup with Minnesota, they will travel to Phoenix to take on the Suns on Friday. Friday, Dec. 27 | at Phoenix Suns - 8 p.m. on KFAA Saturday, Dec. 28 | at Portland Trailblazers - 9 p.m. on KFAA Monday, Dec. 30 | at Sacramento Kings - 9 p.m. on KFAA/NBA TV This article was created with contributions from Tim Reynolds, an Associated Press basketball writer.

EAST RUTHERFORD, N.J. (AP) — Drew Lock is likely going to start at quarterback for the New York Giants against the Indianapolis Colts on Sunday when they try to end a franchise-record 10-game losing streak. Lock started against Atlanta last weekend and his status became an issue after the 34-7 loss when coach Brian Daboll said the 28-year-old was having an issue with his right shoulder. An MRI was done Monday and Daboll announced Tuesday that Lock would be his starter if he stayed healthy. “It came back good so rocking and rolling,” Lock said, noting he was hurt on a third down pass to Daniel Bellinger in the first quarter when Falcons linebacker Matthew Judon pulled his arm on the play. He finished the game. There were questions whether Daboll would switch back to Tommy DeVito after Lock threw two pick-6s and lost a fumble on a strip-sack against the Falcons. Lock has had three interceptions returned for scores in three starts this season, including two on tipped passes. Daboll said it was important to give Lock a couple of starts in which he was able to get all the reps in practice. “Knowing what we did the week before, take the things we need to get better at into this week and actually be able to go out there and do it is something I’m looking forward to,” Lock said. “Similar cadences with the guys, being in the huddle together. I think it can only be a positive for such a roller coaster out of that spot.” The one thing that might change this week is the Giants center. John Michael Schmitz has an ankle injury and he did not practice Tuesday. He left the locker room with a boot on his right foot. New York has moved veteran guard Greg Van Roten to center when Schmitz was hurt and Lock also worked with guard Austin Schlottmann as his center while playing in Denver. “I’m pretty familiar with all the guys that are rotating in there,” Lock said. The Giants have the NFL's worst scoring offense, averaging 14.3 points. They benched Daniel Jones coming out of their bye week and days later released him after he requested it. DeVito has started two games and Lock three since Jones was released. New York has scored 59 points in those games, with 20 coming against Dallas in a seven-point loss on Thanksgiving. Running back Tyrone Tracy (ankle), wide receiver Malik Nabers (knee-foot), cornerback Greg Stroman (shoulder-shin), defensive tackle Cory Durden (shoulder), inside linebacker Micah McFadden (neck) and cornerback Dru Phillips (shoulder) also did not practice on Tuesday, which is usually a day off. The team will have off on Christmas Day and return to practice on Thursday. The Giants opened practice on Tuesday with the song “It’s the Most Wonderful Time of the Year” blaring on the loudspeakers in their indoor practice facility. Jones, who is on the Minnesota Vikings practice squad, sent the Giants offensive linemen Christmas gifts. “DJ comes in, saves me and Tommy once again, and then takes care of the guys,” Lock said. “I expected nothing less from the guy. That’s just who he is, and cares about these guys still.” ___ AP NFL: https://apnews.com/hub/nfl Tom Canavan, The Associated Press