By JONEL ALECCIA, AP Health Writer Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It’s a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It’s all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person’s response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn’t happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It’s not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn’t respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I’m hoping it’s slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.”
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CORK, Ireland , Dec. 5, 2024 /PRNewswire/ -- Johnson Controls International plc (NYSE: JCI) (the "Company" or "Johnson Controls"), a global leader for smart, healthy and sustainable buildings, today announced the pricing of its offering of $250 million senior notes due 2032 (the "Additional Notes"). The Additional Notes will be a further issuance of, and form a single series with, the existing $400 million aggregate principal amount of 4.900% senior notes due 2032 that were originally issued on September 14, 2022 by the Company and Tyco Fire & Security Finance, S.C.A., a subsidiary of the Company, as co-issuer. The net proceeds of the Additional Notes will be used for general corporate purposes, including the repayment, redemption or refinancing of outstanding commercial paper and other near-term indebtedness. General corporate purposes may also include acquisitions, additions to working capital, repurchase of ordinary shares, dividends, capital expenditures and investments in the Company's subsidiaries. The closing for the transaction is expected to occur on December 10, 2024 , subject to certain customary closing conditions. BofA Securities and US Bancorp are serving as joint lead book-running managers to facilitate the transaction. Barclays, BBVA and UniCredit Capital Markets are also serving as book-running managers of the offering. The offering of the Additional Notes is being made pursuant to an effective shelf registration statement, prospectus and related prospectus supplement. Copies of the prospectus supplement and the base prospectus may be obtained by contacting BofA Securities, Inc. toll-free at 1-800-294-1322; or U.S. Bancorp Investments, Inc. toll-free at 1-877-558-2607. Investors may also obtain these documents for free by visiting EDGAR on the Securities and Exchange Commission's website at www.sec.gov . This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or other jurisdiction. About Johnson Controls: At Johnson Controls, we transform the environments where people live, work, learn and play. As a global leader in smart, healthy and sustainable buildings, our mission is to reimagine the performance of buildings to serve people, places and the planet. Building on a proud history of nearly 140 years of innovation, we deliver the blueprint of the future for industries such as healthcare, schools, data centers, airports, stadiums, manufacturing and beyond through OpenBlue, our comprehensive digital offering. Today, with a global team of experts, Johnson Controls offers the world's largest portfolio of building technology and software as well as service solutions from some of the most trusted names in the industry. Johnson Controls International plc Cautionary Statement Regarding Forward-Looking Statements Johnson Controls International plc has made statements in this communication that are forward-looking and therefore are subject to risks and uncertainties. Forward-looking statements may be identified by the use of words such as "may," "will," "expect," "intend," "estimate," "anticipate," "believe," "should," "forecast," "project" or "plan" and terms of similar meaning are also generally intended to identify forward-looking statements. However, the absence of these words does not mean that a statement is not forward-looking. Johnson Controls cautions that these statements are subject to numerous important risks, uncertainties, assumptions and other factors, some of which are beyond Johnson Controls' control, that could cause actual outcomes to differ materially from those expressed or implied by such forward-looking statements, including, among others, risks related to: Johnson Controls' ability to develop or acquire new products and technologies that achieve market acceptance and meet applicable quality and regulatory requirements; the ability of Johnson Controls to execute on its operating model and drive organizational improvement; Johnson Controls' ability to successfully execute and complete portfolio simplification, including the completion of the divestiture of the Residential and Light Commercial business, as well as the possibility that the expected benefits of such actions will not be realized or will not be realized within the expected time frame; the ability to hire and retain senior management and other key personnel, including successfully executing Johnson Controls' Chief Executive Officer succession plan; the ability to innovate and adapt to emerging technologies, ideas and trends in the marketplace, including the incorporation of technologies such as artificial intelligence; the ability to manage general economic, business and capital market conditions, including the impact of recessions, economic downturns and global price inflation; fluctuations in the cost and availability of public and private financing for Johnson Controls' customers; the ability to manage macroeconomic and geopolitical volatility, including supply chain shortages and the conflicts between Russia and Ukraine and Israel and Hamas; managing the risks and impacts of potential and actual security breaches, cyberattacks, privacy breaches or data breaches, maintaining and improving the capacity, reliability and security of Johnson Controls' enterprise information technology infrastructure; the ability to manage the lifecycle cybersecurity risk in the development, deployment and operation of Johnson Controls' digital platforms and services; changes to laws or policies governing foreign trade, including economic sanctions, tariffs, foreign exchange and capital controls, import/export controls or other trade restrictions; fluctuations in currency exchange rates; changes or uncertainty in laws, regulations, rates, policies, or interpretations that impact Johnson Controls' business operations or tax status; the ability to adapt to global climate change, climate change regulation and successfully meet Johnson Controls' public sustainability commitments; risks and uncertainties related to the settlement with a nationwide class of public water systems concerning the use of Aqueous Film-Forming Foam; the outcome of litigation and governmental proceedings; the risk of infringement or expiration of intellectual property rights; Johnson Controls' ability to manage disruptions caused by catastrophic or geopolitical events, such as natural disasters, armed conflict, political change, climate change, pandemics and outbreaks of contagious diseases and other adverse public health developments; any delay or inability of Johnson Controls to realize the expected benefits and synergies of recent portfolio transactions; the tax treatment of recent portfolio transactions; significant transaction costs and/or unknown liabilities associated with such transactions; labor shortages, work stoppages, union negotiations, labor disputes and other matters associated with the labor force; and the cancellation of or changes to commercial arrangements. Investors are therefore cautioned not to place undue reliance on any forward-looking statements. For further discussion of certain of these factors, see Item 1A. Risk Factors in the Company's Annual Report on Form 10-K for the fiscal year ended September 30, 2024 , filed with the U.S. Securities and Exchange Commission (the "SEC") on November 19, 2024 and in our subsequent and future filings with the SEC, which are available at www.sec.gov . Investors should understand that it is not possible to predict or identify all such factors and should not consider this list to be a complete statement of all potential risks and uncertainties. The forward-looking statements included in this communication are made only as of the date of this communication, unless otherwise specified, and, except as required by law, the Company assumes no obligation, and disclaims any obligation, to update forward-looking statements to reflect events or circumstances occurring after the date of this communication. INVESTOR CONTACTS: MEDIA CONTACT: Jim Lucas Danielle Canzanella Direct: 414.340.1752 Direct: 203.499.8297 Email: jim.lucas@jci.com Email: danielle.canzanella@jci.com Michael Gates Direct: 414.524.5785 Email: michael.j.gates@jci.com View original content to download multimedia: https://www.prnewswire.com/news-releases/johnson-controls-prices-senior-notes-offering-302324369.html SOURCE Johnson Controls International plcI'M A Celebrity star Danny Jones is in talks for massive new TV roles following his success in the jungle. ITV bosses are keen to secure Danny, 38, long-term as one of its main players, alongside family favourites including Joel Dommett and Bradley Walsh . The singer and guitarist had an emotional reunion with his wife Georgia and their six-year-old son Cooper as he crossed the famous jungle bridge last night. He is already a judge on The Voice UK, alongside his bandmate Tom Fletcher , but insiders said telly bosses are keen to sign him up for more shows. A source said: “Danny is the embodiment of everything ITV loves. He’s fun, family friendly and incredibly popular. “Watching how popular he was on I’m A Celeb made him a key target for other shows they have coming up. Danny is a brilliant musician, but he is also great on TV. READ MORE ON I'M A CELEB "ITV bosses want to see if they can sign him on for another series of The Voice UK and there are other shows they think he could be perfect on.” Danny won over I’m A Celeb viewers early on as he opened up on his struggles with mental health . During the first week, he broke down in tears as he revealed he started having therapy for anxiety aged 19 after suffering a panic attack during a live TV interview. He also spoke about his estrangement from his dad Alan , 72, who he has not seen for 18 years after he left his mum, Kathy. Most read in I’m A Celebrity 2024 Danny said: “He doesn’t speak to me. I just don’t think I’ve really... healed with it, maybe. I had a good relationship with my dad. He was my best mate until he left.” i'm A Celebrity is back for its 24th series, with a batch of famous faces living in the Aussie jungle. The Sun's Jake Penkethman takes a look at the stars on the show this year.. Coleen Rooney - Arguably the most famous name in the camp, the leading WAG, known for her marriage to Wayne Rooney , has made a grand return to TV as she looks to put the Wagatha Christie scandal behind her. The Sun revealed the mum-of-four had bagged an eye-watering deal worth over £1.5million to be on the show this year making her the highest-paid contestant ever. Tulisa - The popstar and former X Factor judge has made her triumphant TV comeback by signing up to this year's I'm A Celeb after shunning TV shows for many years. Known for being a member of the trio, N-Dubz , Tulisa became a household name back in 2011 when she signed on to replace Cheryl on ITV show The X Factor in a multi-million pound deal. Alan Halsall - The actor, known for playing the long-running role of Tyrone Dobbs on ITV soap opera Coronation Street , was originally signed up to head Down Under last year but an operation threw his scheduled appearance off-course. Now he has become the latest Corrie star to win over both the viewers and his fellow celebrities. Melvin Odoom - The Radio DJ has become a regular face on TV screens after rising to fame with presenting roles on Kiss FM, BBC Radio 1 and 4Music. Melvin has already been for a spin on the Strictly dancefloor and co-hosted The Xtra Factor with Rochelle Humes in 2015 but now he is facing up to his biggest challenge yet - the Aussie jungle . GK Barry - The UK's biggest social media personality, GK, whose real name is Grace Keeling, has transformed her TikTok stardom into a lucrative career. Aside from her popular social media channels, she hosts the weekly podcast, Saving Grace, and regularly appears on ITV talk show, Loose Women . She has even gone on to endorse popular brands such as PrettyLittleThing, KFC and Ann Summers. Dean McCullough - A rising star amongst this year's bunch of celebs , Dean first achieved notability through his radio appearances on Gaydio and BBC Radio 1. He was chosen to join the BBC station permanently in 2021 and has featured prominently ever since. He has enjoyed a crossover to ITV over the past year thanks to his guest slots on Big Brother spin-off show, Late & Live. Oti Mabuse - The pro dancer has signed up to her latest TV show after making her way through the biggest programmes on the box. She originally found fame on Strictly Come Dancing but has since branched out into the world of TV judging with appearances on former BBC show The Greatest Dancer as well as her current role on ITV's Dancing On Ice . Danny Jones - The McFly star was drafted into the programme last minute as a replacement for Tommy Fury. Danny is the second member of McFly to enter the jungle , after Dougie Poynter won the show in 2011. He is also considered a rising star on ITV as he's now one of the mentors on their Saturday night talent show, The Voice , along with bandmate Tom Fletcher . Jane Moore - The Loose Women star and The Sun columnist is braving the creepy crawlies this year. The star is ready for a new challenge - having recently split from her husband . It will be Jane's first foray into reality TV with the telly favourite having always said no to reality shows in the past. Barry McGuigan - Former pro boxer Barry is the latest fighting champ to head Down Under following in the footsteps of Tony Bellew and Amir Khan . It comes after a tough few years for Irish star Barry, who lost his daughter Danika to bowel cancer . He told The Late Late Show in 2021: "She was such an intrinsic part of the family that every day we ache." Maura Higgins - The Irish TV beauty first found fame on Love Island where she found a brief connection with dancer Curtis Pritchard . Since then, she has competed on Dancing On Ice as well as hosting the Irish version of the beauty contest, Glow Up. Since last year, she has been working on building up her career in the US by being the social media correspondent and host of Aftersun to accompany Love Island USA. She even guest hosted an episode of the spin-off, Love Island Games, in place of Maya Jama last year. Rev. Richard Coles - Former BBC radio host the Rev Richard Coles is a late arrival on I’m A Celebrity , and he's ready to spill the beans on his former employer. The former Communards and Strictly star , said the BBC did not know its a**e from its elbow last year. An insider said: "Rev Coles will have a variety of tales to tell from his wild days as a pop star in the Eighties, through to performing on Strictly and his later life as a man of the cloth."NASHVILLE, Tenn. (AP) — The Tennessee Titans have the slimmest of playoff hopes and must win out to have any chance of keeping them alive. Figuring out who they are would be a first step in the right direction. The Titans (3-9) also must bounce back from last week's ugly loss at Washington that cost this franchise yet another chance to string together consecutive wins for the first time in more than two years. “We know that this is a big opportunity for us to develop as a team and to create and to continue developing our identity,” quarterback Will Levis said. “And so we’re going to make sure that we do our best throughout these next few weeks to do that.” The Jacksonville Jaguars (2-10) lost Trevor Lawrence for the rest of the season after the hit he took from Texans linebacker Azeez Al-Shaair in last week's 23-20 loss to Houston. Their already dim playoff hopes were extinguished Monday night when Denver won. That leaves the Jaguars playing for pride and potentially drafting No. 1 overall for the third time in five years. “It’s all about how you finish,” tight end Evan Engram said. “How we finish probably won’t erase the feeling we have of the season. But as the pride of this franchise, the pride of the team, it’s definitely worth going to finish strong and going to get some wins and fighting for that.” The Titans went into Washington with one of the NFL's stingiest defenses and wound up shredded, giving up a season-worst 267 yards rushing. Defensive coordinator Dennard Wilson said, “We can’t allow what happened last week to happen again.” Wide receiver Calvin Ridley says he's excited to see some old teammates Sunday and downplayed a question about how close Jacksonville's offer to keep him last March might've been when he chose to sign with division rival Tennessee instead. “Doesn't matter right now,” Ridley said. “I'm excited for this week. Jags come in here, play with my boys. I'm excited.” Ridley played one season with Jacksonville after the Jaguars traded for him . He had 76 catches for 1,016 yards and eight TDs last season with the Jaguars. So far this season, Ridley has 43 receptions for 679 yards and three TDs. “I just know I'm going to be ready,” Ridley said. Jacksonville has lost 16 consecutive games when tied or trailing at halftime. It’s a complete flip from the 2022 season, in which the Jaguars rallied to beat Dallas, the Las Vegas Raiders and Tennessee down the stretch to make the playoffs. The 20-16 victory against the Titans in the regular-season finale that year is the last time coach Doug Pederson’s team has come from behind to win after trailing or being tied at the break. Tennessee led 13-7 at the half in that one and was minutes from winning a third straight AFC South title . Jaguars defensive end Josh Hines-Allen needs 4 1/2 sacks to break the franchise record of 55 held by Tony Brackens. Hines-Allen has at least half a sack in four consecutive games against Tennessee, which has given up 43 sacks in 2024. “My family knows about it probably more than me,” Hines-Allen said. “My wife tells me all the time, ‘Hey, get that record. All you just need is four sacks.’ Like, you can just (get) four sacks. “I had a couple games last year where I had three, so I can’t say it’s out of the realm. But I never had four sacks; don’t know what it feels like to do that in one game. But hopefully speak it into existence.” Mac Jones will be starting at quarterback and is 0-2 with the Jaguars this season. He has one more interception (three) than touchdown passes (two) in five appearances. The Titans are looking to see if Levis can keep building on his strong play of the past month and start turning those into wins. Levis is 1-3 since returning from a strained throwing shoulder. He has seven TD passes with two interceptions for a 101.3 passer rating in his past four games. He also is completing 61.7% of his passes for 960 yards. “The cool thing right now for Will is that as we’ve corrected things, he’s corrected them,” Titans coach Brian Callahan said . “And that’s been really fun to watch as he’s made adjustments from game to game, sometimes even from in the game made an adjustment to a coverage or a read, and that part’s been good to see.” AP Pro Football Writer Mark Long in Jacksonville, Florida, contributed to this report. AP NFL: https://apnews.com/hub/nfl
