wolf night slot The AP Top 25 men’s college basketball poll is back every week throughout the season! Get the poll delivered straight to your inbox with AP Top 25 Poll Alerts. Sign up here . HOUSTON (AP) — Kavion McClain scored 14 points as Texas Southern beat Texas A&M-Kingsville 80-72 on Wednesday. McClain added six assists for the Tigers (2-5). Grayson Carter scored 13 points, shooting 6 of 7 from the field. Kenny Hunter and Alex Anderson both added 12. The Javelinas were led by Isaiah Payne, who recorded 18 points and four assists. Texas A&M-Kingsville also got 16 points from Allen Singleton. Nate Lacewell also had 13 points and seven rebounds. ___ The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .McClain's 14 lead Texas Southern over Texas A&M-Kingsville 80-72

LIVERPOOL, England (AP) — Kylian Mbappe hoped his move to Real Madrid would finally see him end his wait to win the Champions League. Instead, the France international and defending champion Madrid are in danger of being eliminated from European club soccer's elite tournament at the first stage after Wednesday's 2-0 loss to Liverpool leaves them in a fight just to make the playoffs for the next round. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.

Emmerdale fans 'work out' how Leyla dies after chilling clue as soap exit 'confirmed'Stocks closed higher on Wall Street, sending the Dow Jones Industrial Average to another all-time high. The Dow added 1% Monday to the record it set on Friday. The S&P 500 rose 0.3%, while the Nasdaq composite rose 0.3%. Treasury yields eased in the bond market after President-elect Donald Trump said he wants Scott Bessent, a hedge fund manager, to be his Treasury Secretary. Smaller companies can feel a big boost from easier borrowing costs, and the Russell 2000 index of small stocks jumped 1.5%, closing just shy of the record high it set three years ago. On Monday: The S&P 500 rose 18.03 points, or 0.3%, to 5,987.37. The Dow Jones Industrial Average rose 440.06 points, or 1%, to 44,736.57. The Nasdaq composite rose 51.18 points, or 0.3%, to 19,054.84. The Russell 2000 index of smaller companies rose 35.36 points, or 1.5%, to 2,442.03. For the year: The S&P 500 is up 1,217.54 points, or 25.5%. The Dow is up 7,047.03 points, or 18.7%. The Nasdaq is up 4,043.48 points, or 26.9%. The Russell 2000 is up 414.96 points, or 20.5%.

NEW YORK — Same iconic statue, very different race. With two-way star Travis Hunter of Colorado and Boise State running back Ashton Jeanty leading the field, these certainly aren't your typical Heisman Trophy contenders. Sure, veteran quarterbacks Dillon Gabriel from top-ranked Oregon and Cam Ward of No. 15 Miami are finalists for college football's most prestigious award as well, but the 90th annual ceremony coming up Saturday night at Lincoln Center in New York City offers a fresh flavor this year. To start with, none of the four are from the powerhouse Southeastern Conference, which has produced four of the past five Heisman winners — two each from Alabama and LSU. Jeanty, who played his home games for a Group of Five team on that peculiar blue turf in Idaho more than 2,100 miles from Manhattan, is the first running back even invited to the Heisman party since 2017. After leading the country with 2,497 yards rushing and 29 touchdowns, he joined quarterback Kellen Moore (2010) as the only Boise State players to be named a finalist. "The running back position has been overlooked for a while now," said Jeanty, who plans to enter the 2025 NFL draft. "There's been a lot of great running backs before me that should have been here in New York, so to kind of carry on the legacy of the running back position I think is great. ... I feel as if I'm representing the whole position." With the votes already in, all four finalists spent Friday conducting interviews and sightseeing in the Big Apple. They were given custom, commemorative watches to mark their achievement. "I'm not a watch guy, but I like it," said Hunter, flashing a smile. The players also took photos beneath the massive billboards in Times Square and later posed with the famous Heisman Trophy, handed out since 1935 to the nation's most outstanding performer. Hunter, the heavy favorite, made sure not to touch it yet. A dominant player on both offense and defense who rarely comes off the field, the wide receiver/cornerback is a throwback to generations gone by and the first full-time, true two-way star in decades. On offense, he had 92 catches for 1,152 yards and 14 touchdowns this season to help the 20th-ranked Buffaloes (9-3) earn their first bowl bid in four years. On defense, he made four interceptions, broke up 11 passes and forced a critical fumble that secured an overtime victory against Baylor. Hunter played 688 defensive snaps and 672 more on offense — the only Power Four conference player with 30-plus snaps on both sides of the ball, according to Colorado research. Call him college football's answer to baseball unicorn Shohei Ohtani. "I think I laid the ground for more people to come in and go two ways," Hunter said. "It starts with your mindset. If you believe you can do it, then you'll be able to do it. And also, I do a lot of treatment. I keep up with my body. I get a lot of recovery." Hunter is Colorado's first Heisman finalist in 30 years. The junior from Suwanee, Georgia, followed flashy coach Deion Sanders from Jackson State, an HBCU that plays in the lower level FCS, to the Rocky Mountains and has already racked up a staggering combination of accolades this week, including The Associated Press player of the year. Hunter also won the Walter Camp Award as national player of the year, along with the Chuck Bednarik Award as the top defensive player and the Biletnikoff Award for best wide receiver. "It just goes to show that I did what I had to do," Hunter said. Next, he'd like to polish off his impressive hardware collection by becoming the second Heisman Trophy recipient in Buffaloes history, after late running back Rashaan Salaam in 1994. "I worked so hard for this moment, so securing the Heisman definitely would set my legacy in college football," Hunter said. "Being here now is like a dream come true." Jeanty carried No. 8 Boise State (12-1) to a Mountain West Conference championship that landed the Broncos the third seed in this year's College Football Playoff. They have a first-round bye before facing the SMU-Penn State winner in the Fiesta Bowl quarterfinal on New Year's Eve. The 5-foot-9, 215-pound junior from Jacksonville, Florida, won the Maxwell Award as college football's top player and the Doak Walker Award for best running back. Jeanty has five touchdown runs of at least 70 yards and has rushed for the fourth-most yards in a season in FBS history — topping the total of 115 teams this year. He needs 132 yards to break the FBS record set by Heisman Trophy winner Barry Sanders at Oklahoma State in 1988. In a pass-happy era, however, Jeanty is trying to become the first running back to win the Heisman Trophy since Derrick Henry for Alabama nine years ago. In fact, quarterbacks have snagged the prize all but four times this century. Gabriel, an Oklahoma transfer, led Oregon (13-0) to a Big Ten title in its first season in the league and the No. 1 seed in the College Football Playoff. The steady senior from Hawaii passed for 3,558 yards and 28 touchdowns with six interceptions. His 73.2% completion rate ranks second in the nation, and he's attempting to join quarterback Marcus Mariota (2014) as Ducks players to win the Heisman Trophy. "I think all the memories start to roll back in your mind," Gabriel said. Ward threw for 4,123 yards and led the nation with a school-record 36 touchdown passes for the high-scoring Hurricanes (10-2) after transferring from Washington State. The senior from West Columbia, Texas, won the Davey O'Brien National Quarterback of the Year award and is looking to join QBs Vinny Testaverde (1986) and Gino Torretta (1992) as Miami players to go home with the Heisman. "I just think there's a recklessness that you have to play with at the quarterback position," Ward said. 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Winless in rivalry, Dan Lanning, No. 1 Oregon determined to tame HuskiesDÜSSELDORF, Germany , Nov. 27, 2024 /PRNewswire/ -- Marstek , an established leader in energy storage technology, successfully hosted the launch event of its Energycube AC Couple ESS at the Solar Solutions Düsseldorf trade show. Wholesalers, installers, and media representatives attended the event, connecting with peers, gaining valuable insights into the industry, and exploring Marstek's latest advancements in renewable energy storage. Peter Yang , CEO of Marstek, expressed his enthusiasm: "We are excited to partner with EUPD to launch the Energycube in Düsseldorf, Germany . This marks a significant milestone in our journey to deliver innovative, accessible energy storage solutions. The Energycube reflects our dedication to efficiency and sustainability, empowering users to achieve energy independence. As the demand for renewable solutions grows, we look forward to presenting this cutting-edge technology to industry experts, partners, and the community." The event highlighted the unveiling of the Energycube alongside a range of Marstek's latest energy solutions. Guests gained valuable insights from EUPD Research's PV market update, which offered a comprehensive look at the evolving photovoltaic and energy storage landscape. The Energycube The Energycube represents a significant advancement in energy storage, providing a user-friendly installation, scalable capacity, and tools for real-time energy management. Key Features of the Energycube: Plug & Play DIY Setup: Designed for straightforward installation without technical expertise, ideal for various environments including forest cabins, yachts, and remote homes. Flexible Energy Capacity: Supports both single and multiple units, allowing scalability up to 10 kW output and a capacity of up to 20.48kWh. Real-Time Global Electricity Prices: Equipped with access to real-time electricity prices across 46 countries, supporting optimized energy cost management. Smart Energy Efficiency: Utilizes peak shaving and valley filling capabilities, enhancing daily energy savings. Hybrid System Compatibility: Allows for the simple upgrade of existing solar installations to a hybrid storage solution, enabling whole-home backup power within minutes. About Marstek Founded in 2009, Marstek is a global leader in renewable energy solutions, specializing in advanced energy storage technologies. With four manufacturing bases and operations across the USA , Germany , Japan , Kenya , and Nigeria , it integrates innovation with a vertically aligned industry chain to deliver scalable, efficient energy systems. Marstek empowers households and businesses with tools that promote energy independence and sustainability. By setting new benchmarks in energy management, Marstek drives the global transition to a cleaner, more sustainable future. Contact: Ricky Ma , ricky.ma@marstek.de Photo - https://mma.prnewswire.com/media/2567857/Marstek_Energycube.jpgCarlsbad, CA, Dec. 13, 2024 (GLOBE NEWSWIRE) -- Palisade Bio, Inc, (Nasdaq: PALI) (“Palisade,” “Palisade Bio” or the “Company”), a clinical-stage biopharmaceutical company focused on developing novel therapeutics for autoimmune, inflammatory, and fibrotic diseases, today announced the closing of its previously announced underwritten public offering for gross proceeds of approximately $5 million prior to deducting underwriting commissions and offering expenses. The offering is comprised of (i) 158,000 Class A Units with each unit consisting of (a) one share of common stock and (b) one common warrant to purchase one share of common stock (the “Common Warrants”), and (ii) 3,120,688 Class B Units with each unit consisting of (a) one prefunded common stock purchase warrant to purchase one share of common stock (“Prefunded Warrants”) and (b) one Common Warrant. The price per Class A Unit is $1.525 and the price per Class B Unit is $1.5249 (collectively, the “Offering”). The Common Warrants have an exercise price of $1.40 per share, are exercisable at issuance, and have a term expiring five years from issuance. Ladenburg Thalmann & Co. Inc. acted as sole bookrunning manager in connection with this Offering. In addition, the Company has granted the underwriter a 45-day option to purchase up to 491,803 additional shares of common stock and/or Common Warrants, solely to cover over-allotments, if any, at the public offering price less the underwriting discounts and commissions. In connection with the Offering, the Company has elected to reprice approximately one million previously issued warrants to $1.40 per share. The gross proceeds from the Offering to the Company, before deducting underwriting discounts and commissions and other Offering expenses and excluding any proceeds that may be received upon the exercise of the Common Warrants and the exercise of the underwriter’s option to purchase additional shares of common stock and/or Common Warrants, were approximately $5 million. The Company currently intends to use the net proceeds of the Offering primarily to fund our Phase 1 clinical trial of PALI-2108, pre-clinical studies, research and development, and working capital. The securities were offered pursuant to a registration statement on Form S-1 (File No. 333-282883), which was declared effective by the United States Securities and Exchange Commission (“SEC”) on December 12, 2024. The securities may be offered only by means of a prospectus which forms part of the effective registration statement. A preliminary prospectus describing the terms of the Offering has been filed with the SEC and is available on the SEC’s website located at http://www.sec.gov . A final prospectus relating to this Offering was filed by the Company with the SEC. Electronic copies of the final prospectus relating to the Offering, when available, may also be obtained by contacting Ladenburg Thalmann & Co. Inc., Prospectus Department, 640 Fifth Avenue, 4th Floor, New York, New York 10019 or by email at prospectus@ladenburg.com . This press release does not constitute an offer to sell or the solicitation of an offer to buy, nor will there be any sales of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of such jurisdiction. About Palisade Bio Palisade Bio is a clinical-stage biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases. The Company believes that by using a targeted approach with its novel therapeutics it will transform the treatment landscape. For more information, please go to www.palisadebio.com . Forward Looking Statements This communication contains “forward-looking” statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements regarding the over-allotment option. These forward-looking statements are based on the Company’s current expectations. Forward-looking statements involve risks and uncertainties. The Company’s actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, the intended use of net proceeds from the Offering, the extent of our cash runway; our ability to successfully develop our licensed technologies; the timing and outcome of our current and anticipated applications and studies related to our product candidates; estimates about the size and growth potential of the markets for our product candidates, and our ability to serve those markets, including any potential revenue generated; future regulatory, judicial, and legislative changes or developments in the United States (U.S.) and foreign countries and the impact of these changes; our ability to maintain the Nasdaq listing of our securities; our ability to build a commercial infrastructure in the U.S. and other markets; our ability to compete effectively in a competitive industry; our ability to identify and qualify manufacturers to provide API and manufacture drug product; our ability to enter into commercial supply agreements; the success of competing technologies that are or may become available; our ability to attract and retain key scientific or management personnel; the accuracy of our estimates regarding expenses, future revenues, capital requirements and needs for additional financing; our ability to obtain funding for our operations; our ability to attract collaborators and strategic partnerships; and the impact of any global event on our business, and operations, and supply. Any statements contained in this communication that are not statements of historical fact may be deemed to be forward-looking statements. These forward-looking statements are based upon the Company’s current expectations. Forward-looking statements involve risks and uncertainties. The Company’s actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, the Company’s ability to advance its nonclinical and clinical programs, the uncertain and time-consuming regulatory approval process; and the Company’s ability to secure additional financing to fund future operations and development of its product candidates. Additional risks and uncertainties can be found in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2023, filed with the Securities and Exchange Commission (“SEC”) on March 26, 2024, and the Quarterly Reports on Form 10-Q or other SEC filings that are filed thereafter, including the Registration Statement on Form S-1. These forward-looking statements speak only as of the date hereof, and the Company expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in the Company’s expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based. Investor Relations Contact JTC Team, LLC Jenene Thomas 908-824-0775 PALI@jtcir.com

Ruud van Nistelrooy ‘disappointed’ and ‘hurt’ after cutting ties with Man UtdThe Dodgers signed one of the top free agent pitchers on the market. It's just another example of how the rich get even richer in MLB without a salary floorMcClatchy Completes Merger with accelerate360

REDWOOD CITY, Calif., Dec. 02, 2024 (GLOBE NEWSWIRE) -- Biomea Fusion, Inc. (Nasdaq: BMEA) (“Biomea” or the “Company”), a clinical stage biopharmaceutical company focused on the discovery and development of oral covalent small molecules to treat and improve the lives of patients with diabetes, obesity, and genetically defined cancers, today announced that on December 2, 2024, the compensation committee of Biomea’s board of directors granted one new employee non-qualified stock options to purchase an aggregate of 30,000 shares of the Company’s common stock. The shares underlying the employee’s stock options will vest 1/16 on a quarterly basis over four years, subject to the employee’s continued employment with the Company on such vesting dates. The above-described award was made under Biomea’s 2023 Inducement Equity Plan (the “Plan”). The above-described award was granted as an inducement material to the employee entering into employment with the Company in accordance with Nasdaq Listing Rule 5635(c)(4) and was granted pursuant to the terms of the Plan. The Plan was adopted by Biomea’s board of directors on November 17, 2023. About Biomea Fusion Biomea Fusion is a clinical-stage biopharmaceutical company focused on the discovery and development of oral covalent small molecules to improve the lives of patients with diabetes, obesity, and genetically defined cancers. A covalent small molecule is a synthetic compound that forms a permanent bond to its target protein and offers a number of potential advantages over conventional non-covalent drugs, including greater target selectivity, lower drug exposure, and the ability to drive a deeper, more durable response. We are utilizing our proprietary FUSIONTM System to discover, design and develop a pipeline of next-generation covalent-binding small-molecule medicines designed to maximize clinical benefit for patients. We aim to have an outsized impact on the treatment of disease for the patients we serve. We aim to cure. Visit us at biomeafusion.com and follow us on LinkedIn , X and Facebook . Contact: Investor & Media Relations Ramses Erdtmann re@biomeafusion.comIt’s common to hear how amazing full-spectrum CBD oil is — but plenty of others say it doesn’t work. One look at the price tag only deepens the internal conflict. Do you try it and hope for the best, or do what you’ve been doing? Is it worth the risk? The good news is you don’t have to risk anything . While CBD can be a powerful force against pain, insomnia, and anxiety, it doesn’t work the same for everyone — that’s why some brands have a money-back guarantee. We’ll cover the best full-spectrum oils based on quality and effectiveness, some of the top uses, and even explain what full-spectrum is. Through considerable research, we selected these products based on careful evaluation of the company’s reputation, transparency, and quality control practices. Our top picks for the best full-spectrum CBD oils include: Royal CBD Full-Spectrum Hemp Oil (BEST VALUE) GoldBee Full Spectrum CBD Oil (RUNNER-UP) Area 52 UFO Full-Spectrum THC/CBD Oil (STRONGEST OVERALL) Colorado Botanicals Full-Spectrum CBD Oil NuLeaf Naturals Full Spectrum CBD Oil Lazarus Naturals High Potency Full Spectrum CBD Tincture CBDistillery Full Spectrum CBD Oil Charlotte’s Web Original Formula CBD Oil Cornbread Hemp Whole Flower CBD Oil We only chose brands that use organically sourced, non-GMO hemp and employ clean extraction methods, so you know every product on this list is worth the money. Let’s get started! 1. Royal CBD Full-Spectrum Hemp Oil (Best Value) Pros & Cons: Highly potent : A high dosage of 2,500 mg full-spectrum CBD can deliver effective relief for a variety of ailments. Versatile : The full-spectrum formula with a convenient dropper makes dosing easy for beginners and experienced users alike. Solvent-free extraction : Royal CBD’s solventless extraction guarantees a pure, contaminant-free oil. Positive customer reviews : Real customers say the oil helps with pain and stress relief. Save 15% Use the code below to cut 15% off anything you order at Royal CBD. Royal CBD is a California-based company founded in 2018, committed to producing high-quality, organic CBD products. The brand focuses on transparency and ethical sourcing, and it uses non-GMO, U.S.-grown hemp. Royal CBD commits to purity and quality in its range of products, including gummies, oils, tinctures, and capsules — all products undergo third-party lab testing so you can check the lab reports and know what you’re getting. The 2,500 mg full-spectrum CBD oil deserves a spot on any list for those seeking strong, effective CBD tinctures. This oil is ideal for users needing significant relief from conditions like chronic pain or anxiety. Royal CBD’s dedication to using CO 2 extraction methods ensures that you receive a pure, reliable product free from harmful solvents. Each serving of this full-spectrum oil contains a whopping 83 mg of CBD per serving, making it the most potent oil on this list. Start with a low dose of one-quarter or one-half dropper to see how it affects you, then increase your dose. Looking for targeted pain relief? Royal CBD has you covered with the CBD Cream (Cool Relief Balm) . This broad-spectrum CBD balm is perfect if you want a THC-free product, and it’s simple to use — just massage it onto your skin where you need relief and wait for the cannabinoids and terpenes to do their thing. Royal CBD Coupon Code: Enter MG15 for 15% off any purchase. Royal CBD 2,500 mg CBD Oil Specs: Potency : 🔥🔥🔥🔥🔥 Flavor : Natural hemp Third-party lab tested : Yes Packaging : Comes in a 30 mL bottle with a dropper for easy dosing Price : $229 Cannabinoids : 2,500 mg of CBD (83 mg per serving) Serving size: 1 dropper (1 mL) Review Summary: Potency : 5/5 - High concentration of full-spectrum CBD for intense relaxing effects Flavor : 4/5 - Enjoyable natural hemp flavor Third-Party Testing : 5/5 - Consistent quality assurance and transparent lab results Price : 5/5 - Definitely worth the price for the level of quality and potency you get from this full-spec oil (only $0.06 per mg) 2. GoldBee Full Spectrum CBD Oil (Runner-Up) Pros & Cons: High-quality full-spectrum formulation : Offers a wide range of cannabinoids for an effective experience Organic ingredients : Uses US-grown, certified organic and natural ingredients Multiple strengths available : Choose between 600, 1200, or 2400 mg of CBD to see what works best Budget-friendly : Excellent value for a premium full-spectrum CBD oil Slightly thick consistency : The thickness of the oil could make it challenging to mix with drinks GoldBee began to take the cannabis industry by storm in 2019. The company started as a small family-owned business focused on creating natural wellness products. Based in California, the company commits to sustainability and quality, using organically grown, non-GMO hemp sourced from Colorado. GoldBee is known for its holistic approach to CBD, offering a range of products, including capsules, oils, and gummies, all made with a focus on plant-based ingredients and honey for added natural benefits. The Full-Spectrum CBD Oil from GoldBee earns its spot for combining purity with efficacy. It's a great option if you’re seeking moderate potency and a natural approach to wellness, whether for stress relief, inflammation, or sleep support. This oil contains the full range of cannabinoids and terpenes, enhancing its therapeutic effects through the "entourage effect." With GoldBee’s money-back guarantee, you can return most products within 45 days as long as you’ve used less than half of the product and still have the original packing slip. Plus, shipping is always free! If you’re all-in for organic CBD but don’t like oil, check out the Vegan CBD Gummies from GoldBee. Each tasty chew has 25 mg of broad-spectrum CBD (so there’s no THC!), and you can easily adjust your dose by taking half a gummy or more than one gummy. GoldBee Coupon Code: Enter code BEE15 for 15% off your order. GoldBee Full Spectrum CBD Oil Specs: Potency : 🔥🔥 Flavor : Natural, lychee, kiwi Third-party lab tested : Yes Packaging : 30 mL bottle Price : $109 Cannabinoids : 1,200 mg of CBD (40 mg per serving) Serving size : 1 dropper (1 mL) Review Summary: Potency : 4/5 - Effective for various users but may not satisfy all Flavor : 4/5 - Tasty natural flavors (unsweetened or honey-infused) Third-Party Testing : 5/5 - Consistent quality checks from reliable third-party labs Price : 4/5 - Excellent price point and cheaper than Royal, but also less potent 3. Area 52 UFO Full-Spectrum (CBD + THC) Oil (Strongest Overall) Pros & Cons: High THC content : Enjoy the mind-altering effects of THC and the relaxing effects of CBD and CBG in one tincture Sweet strawberry flavor : If you don’t like the taste of hemp, you’ll love the taste of natural strawberry extract, stevia, and a proprietary terpene blend Discount code : The coupon code makes it easy to save on your order If you are looking for a high-THC oil that also contains CBD, Area 52’s UFO Full-Spectrum THC/CBD Oil could be your perfect match. Area 52 is all about how THC can enhance cerebral thinking and creativity. Using advanced supercritical CO 2 extraction processes, the team derives pure cannabinoids from hemp and adds natural flavorings to produce some of the highest-quality CBD products on the market. You get NO fillers, NO additives, and NO harmful contaminants — and it’s all backed up by third-party lab tests. Flavored with a proprietary blend of Strawberry Cough terpenes, this potent tincture packs a potent blend of 40 mg CBD, 10 mg CBG, and 2.5 mg THC per serving. All of the full-spectrum oils on this list contain some THC, but this Area 52 tincture is best for people who want to push the limits with the most potent (but still Farm Bill-compliant) full-spectrum CBD oil. Although it’s a bit pricey at $169 dollars, you can buy two or three bottles at once to save up to $128, or you can set up a subscription and receive a bottle every month and save 15% while you’re at it. Not to mention, Area 52 offers free shipping on orders of $110 or more, so you automatically qualify when you buy this tincture. If you don’t love the product (or if the effects are just too strong for you), you can return it within 30 days for a refund. Each 60 mL bottle contains around 60 servings, but you can choose your own adventure when it comes to dosing: take 1/2 a dropper for “chill mode” and relaxing stress-relieving effects. Or, kick it up a notch with “space mode” and take a full dropper or two — you’ll space out with mind-altering effects from over 10 mg of Area 52’s finest delta 9 THC. Looking for a THC oil that winds you down instead of hyping you up? Check out Area 52’s Neptune Sleep Tincture , which combines CBD, CBN, melatonin, and soothing chamomile to help you fall asleep — and get better-quality sleep. Area 52 Coupon Code: Enter code FIRST15 for 15% off your order. Area 52 UFO Tincture (CBD + THC) Specs: Potency : 🔥🔥🔥🔥🔥 Flavor : Strawberry Third-party lab tested : Yes Packaging : 60 mL bottle Price : $169 Cannabinoids : 3,100 mg full-spectrum (40 mg CBD, 10 mg CBG, and 2.5 mg THC per serving) Serving size : 1/2 dropper (1 mL) for “chill mode,” 1–2 droppers (2 mL) for “space mode Review Summary: Potency : 5/5 - Perfect if you want higher levels of THC, and you can choose your dose from 1/2 a dropper to 2 full droppers Flavor : 4/5 - Sweet, natural strawberry flavor is a crowd favorite Third-Party Testing : 5/5 - Area 52 publishes up-to-date third-party lab test results Price : 3/5 - Decent value for the ultra-high potency ($2.82 per mL) 4. Colorado Botanicals Full-Spectrum CBD Oil Pros: Suitable for various dietary needs : Vegan, gluten-free, and organic formula is perfect for all users. CO2 extraction process : Uses a gentle proprietary pharmaceutical extraction method to preserve terpenes, flavor, and purity. Cons: Limited flavor options : With just one peppermint flavor, you don’t have much choice when it comes to taste Costly product : Might be too expensive for some people Availability may vary : You might not be able to find this oil in some regions Colorado Botanicals came on the scene in 2017 and has quickly made a name for itself by focusing on pharmaceutical-grade, high-quality CBD products. Located in Colorado, the company is unwavering in transparency, purity, and advanced extraction methods that retain as many beneficial plant compounds as possible. This brand is a good one-stop shop for oils, topicals, and capsules. The full-spectrum CBD oil is a standout for its attention to detail in maintaining the integrity of the plant’s compounds. With a full-spectrum formula, you get the benefits of several cannabinoids, so it’s a great option for balanced relief from a variety of concerns like inflammation, stress, and pain. Colorado Botanicals Full-Spectrum CBD Oil Specs: Potency : 🔥🔥 Flavor : Peppermint Third-party lab tested : Yes Packaging : 30 mL bottle with a dropper for easy and precise dosing Price : $109.99 Cannabinoids : 1,500 mg of CBD (50 mg per serving) Serving size : 1 dropper (1 mL) Review Summary: Potency : 4/5 - Effective for a range of needs and easy to adjust dose Flavor : 3/5 - Only one minty flavor option Third-party Testing : 5/5 - Regularly tested for quality assurance Price : 3/5 - Premium pricing for high quality 5. NuLeaf Naturals Full Spectrum CBD Oil Pros: Basic ingredients : Contains simple ingredients that you can understand and that offer you a high level of purity Highly effective : Potent formula that's perfect for intense relief Cons: Only “natural” flavor : If you don’t like the taste of hemp, this unflavored oil might not be right for you Lack of availability : Some customers report that it's hard to find in local stores NuLeaf Naturals, established in 2014, has built a reputation as one of the pioneers in the CBD industry. Stationed in Colorado, the company focuses on producing pure, high-quality CBD products with no additives or unnecessary ingredients. The product line is straightforward — full-spectrum CBD oils, soft gels, and pet CBD products. Though it only focuses on a select few offerings, NuLeaf crafts every product with exceptional care and consistency. This CBD oil makes this list for its purity. This oil is made using advanced CO 2 extraction to retain a wide range of cannabinoids and terpenes, so you get the maximum therapeutic benefit from the hemp plant. At 30 mg of CBD per serving, it's not the most potent oil on this list, but it's still a great choice for anyone who needs relief from chronic pain, stress, or inflammation without the complexity of artificial additives. NuLeaf Naturals Full Spectrum CBD Oil Specs: Potency : 🔥🔥🔥 Flavor : Natural Third-party lab tested : Yes Packaging : 30 mL bottle with dropper Price : $89 Cannabinoids : 1,800 mg of CBD (30 mg per serving) Serving size : 10 drops (0.5 mL) Review Summary: Potency : 4/5 - High concentration suitable for severe conditions Flavor : 3/5 - Limited flavor options — just natural hemp flavor Third-Party Testing : 4/5 - Consistent quality checks Price : 4/5 - Good value for the potency 6. Lazarus Naturals High Potency Full-Spectrum CBD Tincture Pros: Cost-effective : Highly potent but still affordable — perfect for budget-conscious buyers Assistance programs : Discounts available for veterans and low-income households Cons: Flavor too strong : The flavor may be too strong, affecting the overall experience Not beginner-friendly : The effects might be too powerful for new users who have not developed a tolerance to the formula Inconsistent results : Some customer reviews say the effects weren’t strong enough to make a difference Lazarus Naturals, founded in 2014, is known for its mission-driven approach to making high-quality CBD accessible to everyone. Hailing from Oregon, the company is vertically integrated, meaning they control every step of the production process from seed to bottle. How does that benefit buyers? Well, Lazarus Naturals is able to offer potent products for near-wholesale prices. The wide variety of items, including oils, capsules, balms, and pet products, are made with a strong commitment to sustainability and ethical sourcing. The High Potency Full-Spectrum CBD Tincture stands out for its exceptional strength and affordability. This tincture is ideal for those needing a stronger dose of CBD to manage more severe conditions like chronic pain, anxiety, or inflammation. At 50 mg of CBD per serving, this budget-friendly oil is in the middle in terms of potency, and you can always take a smaller or larger dose to customize the effects. Lazarus Naturals High Potency Full-Spectrum CBD Tincture Specs: Potency : 🔥🔥🔥 Flavor : Strawberry lemonade, chocolate mint, classic Third-party lab tested : Yes Packaging : 30 mL bottle with dropper (or 120 mL bottle with dropper) Price : $40 Cannabinoids : 1,500 mg of CBD (50 mg per serving) Serving size : 1 mL Review Summary: Potency : 4/5 - Strong and effective for high needs Flavor : 3/5 - Sweet and classic flavors give you options, but all are pretty strong Third-party Testing : 4/5 - Regularly tested for quality Price : 4/5 - Affordable for the potency 7. CBDistillery Full-Spectrum CBD Oil Pros: Multiple potencies : CBD oil is available in various strengths for both beginners and advanced users U.S. Hemp Authority Certified : You know for sure that you’re receiving a high-quality product Cons: Uses ethanol extractio n: Some users don't prefer this method of extraction since the product may contain chemicals High potency : The levels of potency can be too strong for beginners High price : Costly for higher concentrations of the oil CBDistillery has quickly become one of the most recognized names in the CBD industry. Starting in 2016 and operating out of Colorado, the company was created with the mission of making high-quality, affordable CBD products for all. CBDistillery offers a broad range of products, including oils, gummies, soft gels, and topicals, all made from U.S.-grown, non-GMO hemp. The brand’s desire for transparency and education has helped build trust among consumers who want reliable, effective CBD solutions. We selected this full-spectrum CBD oil because of its impressive potency and value. With an impressive 167 mg of CBD per serving, it’s an excellent choice for those who need a stronger, long-lasting option to manage chronic conditions like pain, stress, or sleep issues. If you’re new to CBD oils or have a low tolerance, this may not be the best oil for you since it is ultra-potent. CBDistillery Full-Spectrum CBD Oil Specs: Potency : 🔥🔥🔥🔥🔥 Flavor : Natural Third-party lab tested : Yes Packaging : 30 mL bottle Price : $240 Cannabinoids : 5,000 mg full-spectrum CBD (167 mg per serving) Serving size : 1 dropper (1mL) Review Summary: Potency : 4/5 - Strong enough for experienced users Flavor : 3/5 - Only one “natural” flavor Third-Party Testing : 5/5 - Consistent quality assurance Price : 4/5 - Good value for the quality 8. Charlotte’s Web Original Formula CBD Oil Pros: Established brand: The brand has developed a strong reputation and trust among users Good customer reviews : Positive feedback from users regarding their experience with the product Reliable sourcing : Known for consistent quality and ethically sourced non-GMO hemp grown in the USA Cons: Higher price point : Expensive pricing may not suit all budgets Customer service issues : Mixed reports about the customer support available Charlotte's Web was created in 2013 and is one of the most well-known and respected brands around. The Colorado company was founded by the Stanley brothers, who developed their CBD products to help a young girl named Charlotte Figi manage her severe epilepsy. Since then, Charlotte's Web has grown into a leading provider of high-quality, hemp-derived CBD products, offering oils, capsules, gummies, and topicals, all crafted with care from non-GMO, U.S.-grown hemp. The Original Formula CBD Oil holds a special place on this list because it’s the product that started it all for Charlotte’s Web. Known for its reliability and consistency, this medium-potency oil is effective for comprehensive wellness support for stress, inflammation, and overall balance. It’s an excellent choice for those who prefer a traditional, time-tested formula. Charlotte’s Web Original Formula CBD Oil Specs: Potency : 🔥🔥 Flavor : Olive oil Third-party lab tested : Yes Packaging : 30 mL bottle Price : $94.99 Cannabinoids : 1,500 mg of CBD (25 mg per serving) Serving size : 0.5 mL Review Summary: Potency : 4/5 - Effective for a range of users Flavor : 3/5 - Only one “olive oil” flavor available Third-party Testing : 5/5 - Consistent quality checks Price : 3/5 - Higher but reflective of quality 9. Cornbread Hemp Whole Flower CBD Oil Pros: Rich in cannabinoids : The myriad of cannabinoids offers numerous benefits Gluten-free and vegan : Users who have food allergies can enjoy this CBD oil — the manufacturing facility is free of tree nuts, peanuts, eggs, fish, soybeans, wheat, shellfish, and milk Aids in relaxation : Good reviews for stress and anxiety relief Cons: Earthy taste : The strong natural hemp flavor might be too much for some Low potency : The oil might not suit those who want or need higher doses Cornbread Hemp brings a unique, organic approach to CBD products. Founded in 2019 and based in Kentucky, the company takes inspiration from the state’s rich hemp-growing history, focusing on crafting USDA-certified organic CBD products made from Kentucky-grown hemp. Cornbread Hemp prides itself on using only the finest flower (no stems or leaves) to ensure a higher concentration of cannabinoids and terpenes in its oils. The Whole Flower CBD Oil earned a spot on our list because of its focus on delivering a richer, more potent experience by using the whole hemp flower and organic sugarcane ethanol extraction. This oil is remarkable for users who need a stronger CBD dose to address issues like pain, anxiety, or sleep difficulties. Why? It's all thanks to its higher concentration of full-spectrum cannabinoids and terpenes. This whole-flower oil contains 2 mg of THC per serving, which can enhance the soothing, euphoric effects and help you relax. However, THC can also produce psychoactive effects, even at low doses, so start low and slow with your doses. Cornbread Hemp Whole Flower CBD Oil Specs: Potency : 🔥🔥 Flavor : Natural hemp Third-party lab tested : Yes Packaging : 30 mL bottle Price : $74.99 Cannabinoids : 1,500 mg of CBD (50 mg per serving) Serving size : 1 dropper Review Summary: Potency : 3/5 - Effective but less potent compared to top brands Flavor : 3/5 - Natural, earthy taste Third-party Testing : 4/5 - Regularly tested for quality Price : 4/5 - Good value for organic quality Full-spectrum CBD oil is derived from the whole hemp plant, which means it contains the “full spectrum” of natural compounds in the plant, including terpenes, flavonoids, cannabinoids, and essential oils. It includes trace amounts of THC (less than 0.3%), which has its own medicinal benefits and can add to the oil’s overall effects. All of the cannabinoids and terpenes contribute to a phenomenon called the "entourage effect," where these compounds work together to enhance therapeutic benefits. To compare, broad-spectrum CBD oil contains CBD and other cannabinoids — but no THC. CBD isolate contains only one cannabinoid (CBD). Full-spectrum CBD oil offers a wide range of potential health benefits, thanks to the combined effects of cannabinoids, terpenes, and other plant compounds. One of the most common reasons people use full-spectrum CBD oil is for pain management , especially for conditions like arthritis, fibromyalgia, and chronic back pain [1]. CBD interacts with the body’s endocannabinoid system to help reduce inflammation and alleviate discomfort. Many people also turn to CBD oil for anxiety and stress relief . CBD has calming effects on the central nervous system, which can help manage anxiety disorders, reduce stress levels, and promote relaxation . Full-spectrum CBD, which contains trace amounts of THC, can also produce euphoric effects that help you relax. Sleep improvement is another popular use of CBD oil. Addressing underlying issues like anxiety and discomfort can help you fall asleep faster and enjoy deeper, more restful sleep. Full-spectrum CBD oil is used to support mental health, helping those with conditions like depression or PTSD manage their symptoms. It’s also FDA-approved in the form of Epidiolex for treating certain types of epilepsy , such as Dravet syndrome and Lennox-Gastaut syndrome. Selecting the right full-spectrum CBD oil can be overwhelming due to the wide variety of products on the market. We’ve got you covered with a list of the factors to keep in mind to help you choose a product that’s both safe and effective. 1. Potency Potency refers to the concentration of CBD in the oil, typically measured in milligrams (mg). This can vary significantly from product to product, with lower-potency oils containing around 300 mg of CBD per bottle and higher-potency oils offering up to 3,000 mg or more. For example, the Royal CBD Full-Spectrum CBD Oil contains 2,500 mg of CBD per bottle (83 mg per serving), whereas the GoldBee Full-Spectrum CBD Oil has just 40 mg per serving. The right potency depends on your experience with CBD and how intense you want the effects to be. If you’re new to CBD, starting with a lower concentration and gradually increasing it is a safe approach. ⟹ Click Here for the Strongest THC Oil On the Market Right Now 2. Purity Purity refers to the absence of contaminants or unwanted additives in your CBD oil. It’s crucial to choose products made from high-quality, organically grown hemp , which reduces the risk of pesticides, heavy metals, and other toxins making their way into the final product. Avoid products that contain artificial ingredients or fillers, which can dilute the effectiveness of the CBD. 3. Source of Hemp The quality of the hemp used to make CBD oil plays a significant role in the overall quality of the product. Hemp plants absorb nutrients and substances from the soil, so hemp sourced from regions with strict agricultural standards, such as the U.S. or Europe, is generally more reliable. Look for brands that use organically grown, non-GMO hemp, as this indicates a commitment to producing a clean and safe product. 4. Extraction Methods The method used to extract CBD from the hemp plant affects the purity and safety of the oil. Other extraction methods, such as solvent-based extraction, may be less desirable as they can leave traces of solvents in the final product. CO 2 extraction is considered the gold standard because it uses carbon dioxide under high pressure and low temperatures to preserve the full spectrum of cannabinoids, terpenes, and other beneficial compounds without leaving behind harmful residues [2]. 5. Third-Party Lab Testing One of the most important aspects of choosing the right CBD oil is verifying its quality through third-party lab testing. Reputable companies will provide lab reports (also known as certificates of analysis) that verify the product’s CBD and THC content, ensuring it contains what’s advertised. These tests also check for contaminants like pesticides, heavy metals, and mold. Always choose a brand that makes these lab results easily accessible to customers, either on the website or via a QR code on the product packaging. 6. THC Levels Since full-spectrum CBD oil contains trace amounts of THC, it’s essential to verify that the THC levels are below the legal limit of 0.3%. This ensures compliance with federal law and reduces the risk of failing a drug test. The lab report will confirm whether the product contains acceptable THC levels, providing peace of mind. 7. Brand Reputation Finally, consider the brand’s reputation. Established brands with positive customer reviews and transparent practices are more likely to offer high-quality products. Be wary of companies making unrealistic health claims or offering products at extremely low prices, as these can be red flags for poor quality or deceptive practices. In the United States, full-spectrum CBD oil is federally legal under the 2018 Farm Bill as long as it contains less than 0.3% THC. However, it's important to check your local laws, as regulations can vary from state to state. It's also important to understand the difference between hemp-derived CBD oil, which is legal, and marijuana-derived CBD oil, which may have stricter regulations due to higher THC levels. When it comes to using full-spectrum CBD oil, safety is a priority. While generally considered safe for most people, it’s important to understand its safety profile, potential side effects, and how it can interact with other medications or health conditions. Before using CBD, consult with your healthcare provider . They can guide you on safe usage, ensure there are no adverse interactions with your current medications, and help adjust dosages if necessary. Your doctor will be able to provide personalized advice based on your health profile, making CBD use safer and more effective. Potential Side Effects of Full-Spectrum CBD Full-spectrum CBD is typically safe for most users. Common side effects include mild drowsiness, dry mouth, and changes in appetite. In rare cases, some individuals may experience dizziness or nausea, especially when taking higher doses. It’s essential to monitor how your body responds, particularly if you’re new to CBD. Interaction With Other Medications & Health Conditions CBD can interact with certain medications, so approach it carefully, especially if you’re taking medications such as blood thinners, antidepressants, anti-seizure medications, or anti-anxiety medications. CBD may increase the levels of these drugs in the bloodstream, potentially leading to harmful side effects . Additionally, if you have liver issues, a history of heart problems, or other medical conditions, you should be particularly cautious. It’s important to recognize potential signs of interaction when using CBD alongside other medications. Watch for unusual symptoms like excessive drowsiness, changes in mood, abnormal bleeding, or difficulty concentrating. If you experience any of these, stop using the product and contact your healthcare provider immediately for further guidance. Dosing CBD oil can vary significantly depending on several factors, including the user’s weight, overall health, the condition being treated, and the concentration of CBD in the product. Because everyone's body responds differently to CBD, finding the right dosage is essential to experiencing its potential benefits. Dose Milligrams of CBD Starting Dose 5–10 mg Adjusting Dose Increase by 5 mg every few days until you reach the desired effect Max Daily Dose 0.43 mg per kilo of body weight [3] It’s best to start with a low dose and slowly increase. It’s a good idea to keep a journal to record your dosages, the effects you notice, and any side effects you may experience. This can help you identify the optimal dosage that works best for your body. How to Take CBD Oil How quickly you feel the effect of full-spectrum CBD oil depends on how you take it. Common ways to take CBD oil include: Sublingual drops — Place several drops of oil under the tongue for faster absorption. You can usually feel the effects within 15–30 minutes. Ingestion — Eat capsules, gummies, or edibles. Effects may take up to two hours to feel but often last longer. Topical application — Enjoy localized pain relief when you rub CBD onto your skin. You may feel effects in 15 minutes or up to one hour. Here are the answers to some of the most commonly asked questions by those who are considering full-spectrum CBD oil for their overall health and wellness. 1. Is a Full-Spectrum CBD Oil Psychoactive? No, due to the low THC content (typically less than 0.3%), full-spectrum CBD oil is not usually psychoactive. The trace amounts of THC are not enough to cause the "high" typically associated with cannabis. However, sensitive individuals may still feel subtle effects. 2. Can a Full-Spectrum CBD Oil Appear on a Drug Test? Yes, full-spectrum CBD oil contains trace amounts of THC, which could show up on a drug test, especially if used frequently or in high doses. Although these amounts are small, some sensitive drug tests might still detect the presence of THC. 3. How Often Can I Take a Full-Spectrum CBD Oil? The frequency of taking full-spectrum CBD oil depends on your needs, health conditions, and desired effects. It's best to start with the manufacturer's dosage recommendations and gradually adjust based on how your body responds, keeping in mind personal tolerance. 4. Is it Safe to Use a Full-Spectrum CBD Oil Every Day? Generally, CBD oil is safe for daily use as long as it is taken according to recommended dosages. However, it's always advisable to speak with a medical professional, especially if you have underlying health conditions or take other medications. 5. Can Children Use a Full-Spectrum CBD Oil? Children should only use full-spectrum CBD oil under strict medical supervision, particularly for FDA-approved conditions like certain types of epilepsy (e.g., Dravet syndrome). It's essential to consult a healthcare provider before considering CBD oil for children. 6. What Should I Do if I Experience Side Effects? If you experience side effects such as dizziness, dry mouth, or fatigue, you should reduce your dosage or discontinue use altogether. It's best to consult a healthcare provider to discuss the side effects and determine if continued use is appropriate for your situation. 7. How Long Does it Take for Full-Spectrum CBD Oil to Work? When used sublingually (under the tongue), full-spectrum CBD oil usually begins to work within 15 to 30 minutes. If ingested through food or drinks, it may take longer, ranging from 30 minutes to 2 hours, as it passes through the digestive system. 8. Can I Use a Full-Spectrum CBD Oil With Other Medications? Consult with a healthcare provider before combining full-spectrum CBD oil with other medications. CBD can interact with certain medications, particularly those metabolized by the liver, potentially affecting their efficacy or causing unwanted side effects. 9. What is the Shelf Life of Full-Spectrum CBD Oils? The typical shelf life of full-spectrum CBD oils is between one and two years. However, it’s essential to check the product’s label for specific expiration dates, as proper storage and packaging can extend or reduce its longevity and overall effectiveness. 10. How Should Full-Spectrum CBD Oil Be Stored? To preserve the potency and freshness of full-spectrum CBD oil, store it in a cool, dark place, away from direct sunlight and heat. Storing it properly will help maintain its quality and extend its shelf life, ensuring it remains effective for longer. ‌Mohammed, S. Y. M., Leis, K., Mercado, R. E., Castillo, Ma. M. S., Miranda, K. J., & Carandang, R. R. (2023). Effectiveness of Cannabidiol to Manage Chronic Pain: A Systematic Review. Pain Management Nursing. de Aguiar, A. C., Vardanega, R., Viganó, J., & Silva, E. K. (2023). Supercritical Carbon Dioxide Technology for Recovering Valuable Phytochemicals from Cannabis sativa L. and Valorization of Its Biomass for Food Applications. Molecules, 28(9), 3849. Henderson, R. G., Vincent, M., Rivera, B. N., Bonn-Miller, M. O., & Doepker, C. (2023). Cannabidiol safety considerations: Development of a potential acceptable daily intake value and recommended upper intake limits for dietary supplement use. Regulatory toxicology and pharmacology, 144, 105482.

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