Scemblix demonstrated sustained superior major molecular response (MMR) vs. all investigator-selected TKIs (74.1% vs. 52%) and vs. imatinib alone (76.2% vs. 47.1%), meeting both ASC4FIRST 96-week key secondary endpoints 1 Scemblix showed a clinically relevant 15.1% higher MMR rate vs. second generation (2G) TKIs (72.0% vs. 56.9%) 1 96-week data extend favorable safety and tolerability profile for Scemblix vs. imatinib and 2G TKIs, with fewer grade ≥3 AEs and less than half the discontinuation rate due to AEs 1 Latest results strengthen Scemblix as a standard of care following expanded indication in newly diagnosed and previously treated adult patents with Ph+ CML-CP and NCCN category 1 recommendation 1-3 Basel, December 8, 2024 – Novartis today announced positive, longer-term results from the pivotal Phase III ASC4FIRST trial with Scemblix ® (asciminib) showing superior major molecular response (MMR) rates at week 96 1 . The study compared the MMR rate of Scemblix to investigator-selected standard-of-care (SoC) tyrosine kinase inhibitors (TKIs) (imatinib, nilotinib, dasatinib and bosutinib) and to imatinib alone in adult patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase (Ph+ CML-CP) at the week 96 evaluation, the study’s key secondary endpoints 1 . The longer-term results showed an increasing difference in Scemblix MMR rate vs. SoC, vs. imatinib and vs. 2G TKIs (nilotinib, dasatinib and bosutinib) 1 . Results were presented at the 66 th American Society of Hematology Annual Meeting & Exposition (ASH) 1 . “These 96-week results are very encouraging for clinicians who aspire to obtain a balance of efficacy and tolerability profiles to help newly diagnosed adult CML patients achieve and maintain treatment goals,” said Jorge Cortes, M.D., Director, Georgia Cancer Center. “The sustained superior efficacy, deeper and more durable responses, and favorable safety and tolerability profile compared to standard of care TKIs continue to support the promise of Scemblix as a potentially practice-changing treatment option.” The median follow-up was 2.2 years for Scemblix and investigator-selected SoC TKIs 1 . Over 22% more patients treated with once-daily Scemblix achieved MMR at week 96 vs. all investigator-selected SoC TKIs, and nearly 30% more patients achieved MMR at week 96 vs. imatinib alone 1 . The Scemblix MMR rate was 15.1% (95% CI: 2.3, 28.0; not crossing zero) higher vs. 2G TKIs (72% vs. 56.9%) 1 . Patients treated with Scemblix also achieved deeper rates of molecular responses (MR4 and MR4.5) compared with investigator-selected SoC TKIs 1 . The safety profile of Scemblix at 96-weeks was consistent with the 4-year follow-up of the Phase III ASCEMBL trial, with no new safety concerns observed to date 1,2,4 . Fewer grade ≥3 AEs and dose adjustments to manage AEs were reported for Scemblix, and discontinuation due to AEs was more than 50% lower for Scemblix vs. both imatinib and 2G TKIs 1 . The most frequent AEs (≥15%) were diarrhea, headache, fatigue, musculoskeletal pain, and rash 1 . Novartis also presented today at ASH interim data from the Phase II ASC2ESCALATE dose-escalation study in both the second line (2L) and newly diagnosed Ph+ CML-CP settings 5 . In the analysis of 2L patients at week 24 (n=28) Scemblix demonstrated MMR rates of 42.9% and deep molecular responses (MR4 25% and MR4.5 10.7%), with a consistent safety and tolerability profile 5 . The most common AEs (>15%) were nausea, hypertension, and vomiting 5 . “Novartis’ decades-long work in CML and deep relationships within the community have informed our Scemblix clinical trial program of over 10 years, the centerpiece of our continuing drive to address ongoing unmet medical needs for people with CML,” said Jeff Legos, Executive Vice President, Global Head of Oncology Development, Novartis. “These latest findings reinforce the differentiated efficacy, safety and tolerability profile of Scemblix in newly diagnosed and previously treated adult CML patients.” Scemblix was recently granted accelerated approval in the US to treat newly diagnosed adults with Ph+ CML-CP, which together with its approval in previously treated adult patients with Ph+ CML-CP expands the population of Scemblix-eligible patients by four-fold 2 . In addition, the National Comprehensive Cancer Network (NCCN) updated its Clinical Practice Guidelines in Oncology (NCCN Guidelines ® ) for the treatment of CML, recommending asciminib as a category 1 – preferred treatment for newly diagnosed Ph+ CML-CP and across all risk categories 3 . About the ASC4FIRST Phase III Clinical Trial ASC4FIRST ( NCT04971226 ) is a Phase III, head-to-head, multi-center, open-label, randomized study of oral Scemblix ® 80 mg QD vs. IS first- or second-generation TKIs (imatinib, nilotinib, dasatinib or bosutinib) in 405 adult patients with newly diagnosed Ph+ CML-CP 2,6 . The trial met both primary endpoints with Scemblix demonstrating superior MMR rates at week 48 vs. investigator-selected SoC TKIs (imatinib, nilotinib, dasatinib and bosutinib) (67.7% vs. 49.0%) and imatinib alone (69.3% vs. 40.2%) as well as the secondary, non-powered endpoint for the 2G TKI stratum of (66% vs 57.8%) 1,6 . The study remains ongoing with further efficacy and safety readouts planned. About the ASC2ESCALATE Phase II Study ASC2ESCALATE ( NCT05384587 ) is a Phase II, multicenter, single-arm, dose-escalation study of oral Scemblix ® 80 mg QD in both the second line (2L) and newly diagnosed (1L) Ph+ CML-CP settings in the US 5,7 . While Scemblix is already approved across lines of therapy, this is the first prospective trial to assess asciminib in the 2L setting and a dose-escalation strategy of asciminib as 2L and 1L treatment for patients with CML-CP not meeting molecular milestones 5 . The proportion of patients achieving MMR at 12 months in the 2L setting will be measured as the primary endpoint 5 . The study remains ongoing and has completed enrollment with 196 patients (100 patients in 2L, 96 patients in 1L) 5 . About Scemblix ® (asciminib) Scemblix ® is the first CML treatment that works by Specifically Targeting the ABL Myristoyl Pocket (referred to as a STAMP inhibitor in scientific literature) 4,8,9 . Other currently approved CML treatments are TKIs that target the ATP-binding site (ATP-competitive) 9 . In the US, Scemblix was granted accelerated approval to treat newly diagnosed adults with Ph+ CML-CP and is also approved for previously treated adult patients with Ph+ CML-CP. Outside the US, it is approved in more than 75 countries, including the EU, to treat those who have previously been treated with two or more TKIs with Ph+ CML-CP 2,10,11 . In some countries, including the US, Scemblix is also approved in patients with Ph+ CML-CP with the T315I mutation 2,3,10 . Scemblix is being studied across multiple treatment lines for Ph+ CML-CP, both as a monotherapy and in combination 2,4,6,8,10,12-24 . Patient Access and Support Novartis, with its 20+ year history in CML, is committed to continuing to address areas of unmet patient need and reducing barriers to patient access and affordability that prevent patients from benefiting from innovation. Novartis Patient Support is available to help guide eligible patients through the various aspects of getting started on treatment including help understanding insurance coverage and identifying potential financial assistance options. Patients or providers can call 866-433-8000 or visit support.scemblix.com to learn more. About Novartis Commitment to CML Novartis has a long-standing scientific commitment to patients living with CML. For more than two decades, our bold science has helped transform CML from a life-limiting condition for many patients. Despite these advancements, there’s still work to be done. We continue to research ways to target the disease more selectively and to address the challenges of not reaching treatment efficacy goals, experiencing treatment resistance and/or intolerance that many patients face. Our legacy inspires our future innovation – we continue to lead the way in developing novel medicines to address serious unmet needs in CML. Our commitment also goes beyond science. Our 20+ year collaboration with the Max Foundation has provided access to Gleevec (imatinib), Tasigna (nilotinib) and now Scemblix and is delivering tremendous patient impact in low- and middle-income countries, with over 100,000 patients supported to date. Disclaimer This press release contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements can generally be identified by words such as “potential,” “can,” “will,” “may,” “committed,” “contingent,” “lead,” “continue,” “ongoing,” “to deliver,” “allowing,” “continuing,” “commitment,” or similar terms, or by express or implied discussions regarding potential marketing approvals, new indications or labeling for Scemblix, or regarding potential future revenues from Scemblix. You should not place undue reliance on these statements. Such forward-looking statements are based on our current beliefs and expectations regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. There can be no guarantee that Scemblix will be submitted or approved for sale or for any additional indications or labeling in any market, or at any particular time. Nor can there be any guarantee that Scemblix will be commercially successful in the future. In particular, our expectations regarding Scemblix could be affected by, among other things, the uncertainties inherent in research and development, including clinical trial results and additional analysis of existing clinical data; regulatory actions or delays or government regulation generally; global trends toward health care cost containment, including government, payor and general public pricing and reimbursement pressures and requirements for increased pricing transparency; our ability to obtain or maintain proprietary intellectual property protection; the particular prescribing preferences of physicians and patients; general political, economic and business conditions, including the effects of and efforts to mitigate pandemic diseases; safety, quality, data integrity or manufacturing issues; potential or actual data security and data privacy breaches, or disruptions of our information technology systems, and other risks and factors referred to in Novartis AG’s current Form 20-F on file with the US Securities and Exchange Commission. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise. About Novartis Novartis is an innovative medicines company. Every day, we work to reimagine medicine to improve and extend people’s lives so that patients, healthcare professionals and societies are empowered in the face of serious disease. Our medicines reach more than 250 million people worldwide. Reimagine medicine with us: Visit us at https://www.novartis.com and connect with us on LinkedIn , Facebook , X/Twitter and Instagram . References Cortes JE, Hochhaus A, Hughes TP, et al. Asciminib Continues to Provide Superior Efficacy and Favorable Safety and Tolerability vs Tyrosine Kinase Inhibitors In Newly Diagnosed Chronic Myeloid Leukemia in ASC4FIRST: Week 96 Update. Presented at: 66th ASH Annual Meeting & Exposition; December 7 – 10, 2024; San Diego, CA. Scemblix (asciminib) Prescribing information. East Hanover, New Jersey, USA: Novartis Pharmaceuticals Corporation; October 2024. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Chronic Myeloid Leukemia Version 2.2025. November 13, 2024. Accessed November 22, 2024. https://www.nccn.org/professionals/physician_gls/pdf/cml.pdf Rea D, Mauro MJ, Boquimpani C, et al. A Phase 3, Open-Label, Randomized Study of Asciminib, a STAMP Inhibitor, vs Bosutinib in CML After 2 or more prior TKIs. Blood. 2021;138(21):2031-2041. doi:10.1182/blood.2020009984 Atallah EL, Levy MY, Koller P, et al. Efficacy and Safety of Asciminib in Chronic Myeloid Leukemia in Chronic Phase (CML-CP): Interim Results from the Phase 2 ASC2ESCALATE Trial in the Cohort of Patients (Pts) after 1 Prior Tyrosine Kinase Inhibitor (TKI). Presented at: 66th ASH Annual Meeting & Exposition; December 7 – 10, 2024; San Diego, CA. A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP (ASC4FIRST). ClinicalTrials.gov identifier: NCT04971226. Updated March 25, 2024. Accessed March 26, 2024. https://clinicaltrials.gov/study/NCT04971226 Asciminib Monotherapy, With Dose Escalation, for 2nd and 1st Line Chronic Myelogenous Leukemia (ASC2ESCALATE) ClinicalTrials.gov identifier: NCT05384587. Updated October 30, 2024. Accessed November 21, 2024. https://clinicaltrials.gov/study/NCT05384587 Cortes JE, Hughes TP, Mauro MJ, et al. Asciminib, a First-in-Class STAMP Inhibitor, Provides Durable Molecular Response in Patients (pts) with Chronic Myeloid Leukemia (CML) Harboring the T315I Mutation: Primary Efficacy and Safety Results from a Phase 1 Trial. Oral presentation at: ASH Annual Meeting; Dec. 7, 2020. Schoepfer J, Jahnke W, Berellini G, et al. Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1. J Med Chem. 2018;61(18):8120-8135. doi:10.1021/acs.jmedchem.8b01040 Novartis data on file. Scemblix. EMA Summary of Product Characteristics. Novartis Europharm Limited; 2022. Wylie AA, Schoepfer J, Jahnke W, et al. The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1. Nature. 2017;543(7647):733-737. doi:10.1038/nature21702 Hughes TP, Mauro MJ, Cortes JE, et al. Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure . N Engl J Med. 2019; 381(24):2315-2326. doi:10.1056/NEJMoa1902328 Hughes TP, et al. Expanded Phase 1 Study of ABL001, a Potent, Allosteric Inhibitor of BCR-ABL, Reveals Significant and Durable Responses in Patients with CML-Chronic Phase with Failure of Prior TKI Therapy. Presented at: ASH Annual Meeting & Exposition; Dec. 5, 2016. Ottmann OG, Alimena G, DeAngelo DJ, et al. ABL001, a Potent, Allosteric Inhibitor of BCR-ABL, Exhibits Safety and Promising Single- Agent Activity in a Phase I Study of Patients with CML with Failure of Prior TKI Therapy. Blood. 2015;126(23):138. doi:10.1182/blood.V126.23.138.138 Mauro MJ, Kim DW, Cortes J, et al. Combination of Asciminib Plus Nilotinib (NIL) or Dasatinib (DAS) in Patients (PTS) with Chronic Myeloid Leukemia (CML): Results from a Phase 1 Study. Presented at: EHA Annual Meeting; June 15, 2019. Cortes JE, Lang F, Kim DW, et al. Combination Therapy Using Asciminib Plus Imatinib (IMA) in Patients (PTS) with Chronic Myeloid Leukemia (CML): Results from a Phase 1 Study. Presented at: EHA Annual Meeting; June 15, 2019. Manley PW, Barys L, Cowan-Jacob SW. The specificity of asciminib, a potential treatment for chronic myeloid leukemia, as a myristate-pocket binding ABL inhibitor and analysis of its interactions with mutant forms of BCR-ABL1 kinase. Leuk Res. 2020;98:106458. doi:10.1016/j.leukres.2020.106458 Study of Efficacy of CML-CP Patients Treated with ABL001 Versus Bosutinib, Previously Treated With 2 or More TKIs. ClinicalTrials.gov identifier: NCT03106779. Updated February 7, 2024. Accessed April 3, 2024. https://clinicaltrials.gov/ct2/show/NCT03106779 Asciminib in Monotherapy for Chronic Myeloid Leukemia in Chronic Phase (CML-CP) With and WithoutT315I Mutation (AIM4CML). ClinicalTrials.gov identifier: NCT04666259. Updated September 7, 2023. Accessed April 3, 2024. https://clinicaltrials.gov/ct2/show/NCT04666259 Study of Efficacy And Safety Of Asciminib In Combination With Imatinib In Patients With Chronic Myeloid Leukemia In Chronic Phase (CML-CP). ClinicalTrials.gov identifier: NCT03578367. Updated March 22, 2024. Accessed April 3, 2024. https://clinicaltrials.gov/ct2/show/NCT03578367 Study of Efficacy and Safety of CML-CP Patients Treated With Asciminib Versus Best Available Therapy, Previously Treated With 2 or More Tyrosine Kinase Inhibitors. ClinicalTrials.gov identifier: NCT04795427. Updated October 19, 2023. Accessed April 3, 2024. https://clinicaltrials.gov/ct2/show/NCT04795427 A Phase I Study of Oral ABL001 in Patients With CML or Ph+ ALL. ClinicalTrials.gov identifier: NCT02081378. Updated March 18, 2024. Accessed April 3, 2024. https://clinicaltrials.gov/ct2/show/NCT02081378 Asciminib Treatment Optimization in ≥ 3rd Line CML-CP. ClinicalTrials.gov identifier: NCT04948333. Updated February 28, 2024. Accessed April 3, 2024. https://clinicaltrials.gov/ct2/show/NCT04948333 # # #Hope is fragile as Assad falls

New Jersey Criminal Defense Attorney Adam M. Lustberg Releases Article Addressing Out-of-State Warrants 12-13-2024 07:44 PM CET | Politics, Law & Society Press release from: ABNewswire New Jersey criminal defense attorney Adam M. Lustberg ( https://www.lustberglaw.com/blog/what-happens-if-you-have-a-warrant-in-another-state/ ), of Lustberg Law Offices, LLC, sheds light on the serious implications of out-of-state warrants. In an informative piece, Lustberg underscores the need for prompt and strategic legal response when confronted with such warrants, which can significantly impact one's legal status and day-to-day life. A warrant issued by one state, known as an out-of-state or interstate warrant, mandates that a person appears in that state to face charges. This can often lead to an extradition process if not resolved proactively. New Jersey criminal defense attorney Adam M. Lustberg emphasizes that these warrants, which can arise from charges ranging from felonies to missed court appearances, must be handled with urgency due to the potential consequences, including detention and a tarnished record. Adam M. Lustberg highlights the role of key legal frameworks such as the U.S. Constitution and the Uniform Criminal Extradition Act (UCEA). These frameworks help ensure that states cooperate on such cases, upholding justice while protecting the accused's rights. "New Jersey's adoption of the UCEA underscores the state's commitment to both uphold the law and safeguard individuals' rights," the New Jersey criminal defense attorney noted. The act lays out the extradition procedures, involving formal requests from the issuing state to apprehend the accused and issue a governor's warrant. New Jersey criminal defense attorney Adam M. Lustberg also explains that being subject to an out-of-state warrant can lead to immediate arrest during routine interactions, such as traffic stops. Once detained, the individual may face potential extradition to the issuing state and subsequent legal proceedings. This makes understanding one's rights and obtaining qualified legal support critical. "It's not just about responding; it's about making informed decisions that protect your future," Lustberg advises. The impact on employment and personal life can be far-reaching, as active warrants typically show up on background checks, potentially hindering job opportunities. Employers may hesitate to hire individuals with unresolved legal issues, which can damage professional prospects and reputations. Addressing the warrant promptly with the guidance of a criminal defense attorney can prevent these long-term repercussions. Lustberg provides insight into the protocols for executing out-of-state warrants in New Jersey. Once a warrant is verified, law enforcement can act to detain the individual. The subsequent extradition hearing serves as a vital checkpoint, where the accused can challenge the warrant's legality, present evidence, and argue for dismissal if there are grounds such as mistaken identity or procedural errors. Effective legal strategies may also involve negotiation with the issuing state's authorities. Adam M. Lustberg notes that such negotiations can sometimes result in reduced charges or alternative resolutions, thereby avoiding jail time and minimizing the personal and professional impact. "Tackling interstate law requires diligence and an experienced approach to protect one's rights," Lustberg states. For those facing an out-of-state warrant, Adam M. Lustberg advises immediate verification of the warrant's legitimacy through official channels. Consulting with a New Jersey criminal defense attorney, such as those at Lustberg Law Offices, LLC, can assist in making informed decisions regarding the best possible course of action-whether it involves voluntary surrender or challenging the warrant's validity. Adam M. Lustberg underscores that the extradition process is not automatic and that it entails significant judicial scrutiny to balance enforcement with individual rights. The accused is entitled to contest the extradition through a hearing where potential defenses can be raised. These might include questioning the warrant's procedural accuracy or the identity of the individual involved. The article by Adam M. Lustberg emphasizes that prompt legal intervention and strategic decision-making are essential to handle out-of-state warrants effectively. With the support of a skilled attorney, individuals can manage this complex legal matter, safeguard their rights, and work towards a favorable outcome. About Lustberg Law Offices, LLC: Lustberg Law Offices, LLC, led by New Jersey criminal defense attorney Adam M. Lustberg, is committed to providing dedicated legal representation for individuals facing various criminal charges. The firm can advocate for clients' rights and tackle the legal system with precision and care. Embeds: Youtube Video: https://www.youtube.com/watch?v=6y91Pz3ZPLY GMB: https://www.google.com/maps?cid=17248268094099978177 Email and website Email: alustberg@lustberglaw.com Website: https://www.lustberglaw.com/ Media Contact Company Name: Lustberg Law Offices, LLC Contact Person: Adam M. Lustberg Email:Send Email [ https://www.abnewswire.com/email_contact_us.php?pr=new-jersey-criminal-defense-attorney-adam-m-lustberg-releases-article-addressing-outofstate-warrants ] Phone: (201) 880-5311 Address:One University Plaza Dr Suite 212 City: Hackensack State: New Jersey 07601 Country: United States Website: https://www.lustberglaw.com/ This release was published on openPR.

NEW YORK (AP) — Kaapo Kaako scored a power-play goal with 24 seconds left, and the New York Rangers stopped a five-game slide by topping the Montreal Canadiens 4-3 on Saturday. Artemi Panarin, Vincent Trocheck and Mika Zibanejad also scored for the Rangers, who got their first win since a 4-3 victory at Vancouver on Nov. 19. Adam Fox had two assists, and Jonathan Quick made 25 saves. With Montreal’s Kirby Dach serving a four-minute, high-sticking penalty, Kaako got his fourth goal of the season. The Canadiens trailed 3-1 after two periods. But Cole Caufield scored his 14th goal 4:16 into the third and Nick Suzuki tied it at 14:07. Trocheck tipped the puck past Montreal goaltender Sam Montembeault at 19:56 to put New York ahead after Panarin and Montreal’s Mike Matheson scored earlier in the first. Panarin put the Rangers ahead at 9:02, scoring on a 5-on-3 for New York’s first power-play goal since Nov. 12 at home against Winnipeg. Matheson tied it at 11:47. Montembault made 24 saves for Montreal. Takeaways Canadiens: dropped to 3-7-1 on the road. Rangers: Forwards Chris Kreider and Filip Chytil returned to the lineup. Kreider missed three games with an upper-body injury while Chytil was out for seven after colliding with teammate K’Andre Miller on Nov. 14. Reilly Smith and Jonny Brodzinski were scratched. Key moment Seeking an early spark, New York captain Jacob Trouba fought Montreal’s Josh Anderson 1:58 into the contest. It appeared to give the Rangers a collective jolt that was missing in recent games. Key stat The Rangers are 11-1-0 when scoring first. It was the 1,700th home win in franchise history. Up next The Canadiens visit the Boston Bruins on Sunday. The Rangers host the New Jersey Devils on Monday. ___ AP NHL: https://apnews.com/hub/NHL Allan Kreda, The Associated Press