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Stocks closed higher on Tuesday, even as a single biotech slid as much as 12% and dragged on the 30-stock Dow Jones Industrial Average. Yields were up too after President-elect Donald Trump said he'll impose new tariffs on Mexico, Canada and China on day one of his new administration. "On Friday, the President-elect used his Truth Social platform to announce hedge fund manager Scott Bessent as his Treasury Secretary, cheering markets with a relatively conventional pick to steer the world's No. 1 economy," writes Bloomberg's Alan Crawford . "But any vague hopes that Trump was going mainstream were short-lived," Crawford continues. "He sent investors into a flap with another post yesterday pledging to hit Mexico and Canada with tariffs of 25% on 'ALL products' entering the US, plus levies of 10% on China." Subscribe to Kiplinger’s Personal Finance Be a smarter, better informed investor. Sign up for Kiplinger’s Free E-Newsletters Profit and prosper with the best of expert advice on investing, taxes, retirement, personal finance and more - straight to your e-mail. Profit and prosper with the best of expert advice - straight to your e-mail. Investors seemed to shrug off the president-elect's after-hours post, reverting to the cautious optimism generated by the Bessent nomination . In an October interview with Matt Peterson of Barron's, Bessent expressed his belief that Trump "won't do anything to take the economy off the cliff." Noting that Alexander Hamilton, America's first Treasury secretary, "also happened to be America's original proponent of tariffs," Bessent in a November 15 Fox News op-ed suggests Trump will deploy them "as a negotiating tool with our trading partners." As Peterson frames it in a follow-up filed today, "The new tariffs plan raises this question: How far Trump can push his attempts at an international economic reordering without upsetting the markets?" Following Monday's sharp declines as investors priced in their initial reaction to the Bessent nomination, yields on both the 10-year U.S. Treasury note and the 2-year U.S. Treasury bill rose again early on Tuesday. The yield on the 10-year was up 3 basis points to 4.30% as of 4 pm Eastern time, while the 2-year yield gave back most of the 5 basis points it added intraday and closed flat at 4.25%. The S&P 500 was up 0.6% at 6,021 – its second-ever close above the 6K level. The Nasdaq Composite added 0.6% to 19,174. And the Dow rallied off its intraday low and closed higher by 0.3% at 44,860. Amgen weighs on the Dow Amgen ( AMGN ) traded down as much as 12.3% Tuesday after the company reported Phase 2 trial data for its weight-loss drug that came up short of Wall Street expectations for its efficacy. The biotech stock closed down 4.8% at $280.01, dragging on the Dow. The drugmaker said non-diabetic overweight or obese patients lost an average of 20% of their body weight after a year on its MariTide therapy, with no plateau. Those results are in line with data for Eli Lilly's ( LLY ) Zepbound, but they're also at the low end of Wall Street expectations. Mizuho Securities America healthcare strategist Jared Holz told CNBC that "investors remain even more confident" that LLY and Novo Nordisk ( NVO ) will lead the weight loss drug market. Novo Nordisk's weight loss drug is called Wegovy. William Blair analyst Matt Phipps said AMGN still offers "a differentiated product profile versus currently approved GLP-1 therapies" and that MariTide has "potential for meaningful market share." Amgen said it will test MariTide in a Phase 3 clinical trial. Stocks on the move Kohl's ( KSS ) stock plunged 17% after the retailer came up short of top- and bottom-line expectations for its third quarter and slashed its full-year outlook due to softness in its apparel and footwear businesses. "We are not satisfied with our performance in 2024 and are taking aggressive action to reverse the sales declines," said CEO Tom Kingsbury in what is his last statement on the retailer's quarterly results as its chief executive. On Monday, Kohl's announced that Kingsbury will step down on January 15, 2025. Ashley Buchanan, the former CEO of Michael's, will become Kohl's third CEO since 2018. Best Buy ( BBY ) stock fell 4.9% after the electronics retailer missed top- and bottom-line expectations for its fiscal third quarter. Management also trimmed Best Buy's full-year outlook. Citing "a combination of the ongoing macro uncertainty, customers waiting for deals and sales events, and distraction during the run-up to the election," CEO Corie Barry said Best Buy "delivered an in-line non-GAAP operating income rate" even though sales "were a little softer than expected." The consumer discretionary stock has enjoyed a solid 2024, rising more than 20% even accounting for Tuesday's decline. But Best Buy is among the companies most exposed to potential new tariffs on imported products. Rivian Automotive ( RIVN ) stock rose as much as 5.7% after the electric vehicle (EV) maker announced it had secured a conditional commitment for a loan of up to $6.6 billion from the U.S. Department of Energy. RIVN closed lower by 0.4%. Proceeds from the loan, should it close, will fund construction of a new EV plant in Georgia and will allow Rivian "to more aggressively scale our U.S. manufacturing footprint for our competitively priced R2 and R3 vehicles that emphasize both capability and affordability," said CEO RJ Scaringe. "Although we still remain confident in the long-term Rivian vision," wrote Wedbush analyst Daniel Ives in a November 8 note, "it will take some serious strides for the company to regain trust in the short-term vision in the eyes of the Street." Incoming economic data The backward-looking minutes from the November FOMC meeting show monetary policymakers continue to focus on incoming data and to prioritize the health of the labor market amid signs of progress in their fight against inflation . "In discussing the outlook for monetary policy, participants anticipated that if the data came in about as expected, with inflation continuing to move down sustainably to 2 percent and the economy remaining near maximum employment," the November FOMC minutes read, "it would likely be appropriate to move gradually toward a more neutral stance of policy over time." According to the CME FedWatch tool , the probability of a 25 basis point rate cut at the next Fed meeting in December is now 59.6%, down from 74.6% on October 25. As for fresh economic data, home price growth in the 20 largest U.S. cities slowed to 4.6% in September from the year-ago period. That's down from a 5.2% increase in the prior month, according to S&P Dow Jones Indices . "Home price growth stalled in the third quarter, after a steady start to 2024," notes Brian D. Luke , head of commodities, real estate and digital assets at S&P Dow Jones Indices. Bright MLS Chief Economist Lisa Sturtevant notes that the home-price index usually "has shown an increase in home price growth between August and September. This year, the September data could be indicative of a slowdown in home price appreciation in the months ahead." New home sales declined 17.3% to a seasonally adjusted annual rate of 610,000 in October from the prior month, according to the Census Bureau . The Conference Board's Consumer Confidence Index rose to 111.7 in November, an increase of 2.1 points from its 109.6 reading in October. "November's increase was mainly driven by more positive consumer assessments of the present situation, particularly regarding the labor market," said Dana M. Peterson , chief economist at The Conference Board. Wednesday's economic calendar is packed. Fresh data on initial jobless claims, durable goods orders, the U.S. trade balance, retail and wholesale inventories, and GDP will be released at 8:30 am Eastern time. Personal Consumption and Expenditures Price Index (PCE) data for October will follow at 10 am. The PCE is the Fed's preferred inflation gauge. Based on data compiled by FactSet, analysts expect the PCE to show a 0.20% month-over-month increase in October vs 0.18% in September. The forecast for the year-over-year rate is 2.3% vs 2.1% in September. The consensus sees core PCE rising 0.29% in October vs 0.25% in September. Year-over-year core PCE is forecast at 2.8% vs 2.7%. Related content Best Dividend Stocks to Buy for Dependable Dividend Growth The Best Large-Cap Stocks to Buy Four Ways to Maximize Your 401(k) Contributions Before the Year Ends

Anze Kopitar scored twice, Adrian Kempe had a goal and an assist, and the Kings got their seventh straight home win by beating the Philadelphia Flyers 5-4 on Sunday night. Kevin Fiala and Warren Foegele also scored for the Kings, who trailed 4-2 midway through the second period before rebounding to sweep a back-to-back after defeating recent playoff nemesis Edmonton in overtime on Saturday. David Rittich made 17 saves. Kopitar was in the right place to redirect Quinton Byfield’s rebound in and tie it at 4 early in the third, before following it up by chopping in Kempe’s shot during a power play at 8:55 for the 5-4 lead. Matvei Michkov had a goal and an assist for the Flyers after being benched for the third period against the Ducks on Saturday. Tyson Foerster, Scott Laughton and Joel Farabee also scored, and Aleksei Kolosov made 15 saves. Takeaways Flyers: Michkov responded well after some tough coaching from John Tortorella, ending a seven-game point drought. Kings: Kopitar is 19 seasons into his Kings career but shows no signs of slowing down. He is up to 12 goals and 27 assists through 36 games. Key moment: Foegele showed good composure in following up his rebound on a breakaway with 4:56 left in the second, getting the Kings back within 4-3 and setting the stage for Kopitar’s final-period heroics. Key stat: The Kings are a resilient bunch, improving to 8-7-1 when allowing the first goal. Up next: The Flyers visit San Jose on Tuesday, and the Kings host New Jersey on Wednesday.

COMMERCE, Texas (AP) — Zach Calzada passed for 333 yards and three touchdowns, and he rushed for a score as Incarnate Word beat East Texas A&M 38-24 on Saturday to claim the Southland Conference title. Incarnate Word (10-2, 7-0) became the first team in program history to finish undefeated in conference play. The No. 6 Cardinals await the FCS selection show on Sunday to learn the playoff matchups. Calzada came in leading the FCS in passing touchdowns with 30 on the season and No. 6 for passing yards (3,018). He finished 26 of 40 with an interception against East Texas A&M. Incarnate Word linebacker Darius Sanders made his third interception in two games then Calzada launched a 43-yard pass to Jalen Walthall to tie it at 14 midway through the second quarter. The Cardinals' Marcus Brown blocked a 45-yard field-goal attempt that would have broken a tie at 24 early in the fourth. Calzada found wide-open Logan Compton in the end zone for a 31-24 lead. Mason Pierce was also left wide open for an 18-yard score with 2:43 left. Ron Peace was 21 of 38 for 165 yards with one touchdown and one interception for East Texas (3-9, 2-4). He also rushed for a score. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-footballATLANTA (AP) — Jimmy Carter, the peanut farmer who tried to restore virtue to the White House after the Watergate scandal and Vietnam War, then rebounded from a landslide defeat to become a global advocate of human rights and democracy, has died. He was 100 years old . The Carter Center said the 39th president died Sunday afternoon, more than a year after entering hospice care , at his home in Plains, Georgia, where he and his wife, Rosalynn, who died in November 2023, lived most of their lives. The center said he died peacefully, surrounded by his family. A moderate Democrat, Carter ran for president in 1976 as a little-known Georgia governor with a broad grin, effusive Baptist faith and technocratic plans for efficient government. His promise to never deceive the American people resonated after Richard Nixon’s disgrace and U.S. defeat in southeast Asia. “If I ever lie to you, if I ever make a misleading statement, don’t vote for me. I would not deserve to be your president,” Carter said. Carter’s victory over Republican Gerald Ford, whose fortunes fell after pardoning Nixon, came amid Cold War pressures, turbulent oil markets and social upheaval over race, women’s rights and America’s role in the world. His achievements included brokering Mideast peace by keeping Egyptian President Anwar Sadat and Israeli Prime Minister Menachem Begin at Camp David for 13 days in 1978. But his coalition splintered under double-digit inflation and the 444-day hostage crisis in Iran. His negotiations ultimately brought all the hostages home alive, but in a final insult, Iran didn’t release them until the inauguration of Ronald Reagan, who had trounced him in the 1980 election. Humbled and back home in Georgia, Carter said his faith demanded that he keep doing whatever he could, for as long as he could, to try to make a difference. He and Rosalynn co-founded The Carter Center in 1982 and spent the next 40 years traveling the world as peacemakers, human rights advocates and champions of democracy and public health. Awarded the Nobel Peace Prize in 2002, Carter helped ease nuclear tensions in North and South Korea, avert a U.S. invasion of Haiti and negotiate cease-fires in Bosnia and Sudan. By 2022, the center had monitored at least 113 elections around the world. Carter was determined to eradicate guinea worm infections as one of many health initiatives. Swinging hammers into their 90s, the Carters built homes with Habitat for Humanity. The common observation that he was better as an ex-president rankled Carter. His allies were pleased that he lived long enough to see biographers and historians revisit his presidency and declare it more impactful than many understood at the time. Propelled in 1976 by voters in Iowa and then across the South, Carter ran a no-frills campaign. Americans were captivated by the earnest engineer, and while an election-year Playboy interview drew snickers when he said he “had looked on many women with lust. I’ve committed adultery in my heart many times,” voters tired of political cynicism found it endearing. The first family set an informal tone in the White House, carrying their own luggage, trying to silence the Marine Band’s traditional “Hail to the Chief" and enrolling daughter, Amy, in public schools. Carter was lampooned for wearing a cardigan and urging Americans to turn down their thermostats. But Carter set the stage for an economic revival and sharply reduced America's dependence on foreign oil by deregulating the energy industry along with airlines, trains and trucking. He established the departments of Energy and Education, appointed record numbers of women and nonwhites to federal posts, preserved millions of acres of Alaskan wilderness and pardoned most Vietnam draft evaders. Emphasizing human rights , he ended most support for military dictators and took on bribery by multinational corporations by signing the Foreign Corrupt Practices Act. He persuaded the Senate to ratify the Panama Canal treaties and normalized relations with China, an outgrowth of Nixon’s outreach to Beijing. But crippling turns in foreign affairs took their toll. When OPEC hiked crude prices, making drivers line up for gasoline as inflation spiked to 11%, Carter tried to encourage Americans to overcome “a crisis of confidence.” Many voters lost confidence in Carter instead after the infamous address that media dubbed his “malaise" speech, even though he never used that word. After Carter reluctantly agreed to admit the exiled Shah of Iran to the U.S. for medical treatment, the American Embassy in Tehran was overrun in 1979. Negotiations to quickly free the hostages broke down, and then eight Americans died when a top-secret military rescue attempt failed. Carter also had to reverse course on the SALT II nuclear arms treaty after the Soviets invaded Afghanistan in 1979. Though historians would later credit Carter's diplomatic efforts for hastening the end of the Cold war, Republicans labeled his soft power weak. Reagan’s “make America great again” appeals resonated, and he beat Carter in all but six states. Born Oct. 1, 1924, James Earl Carter Jr. married fellow Plains native Rosalynn Smith in 1946, the year he graduated from the Naval Academy. He brought his young family back to Plains after his father died, abandoning his Navy career, and they soon turned their ambitions to politics . Carter reached the state Senate in 1962. After rural white and Black voters elected him governor in 1970, he drew national attention by declaring that “the time for racial discrimination is over.” Carter published more than 30 books and remained influential as his center turned its democracy advocacy onto U.S. politics, monitoring an audit of Georgia’s 2020 presidential election results. After a 2015 cancer diagnosis, Carter said he felt “perfectly at ease with whatever comes.” “I’ve had a wonderful life,” he said. “I’ve had thousands of friends, I’ve had an exciting, adventurous and gratifying existence.” Contributors include former AP staffer Alex Sanz in Atlanta.