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SAN FRANCISCO , Dec. 26, 2024 /PRNewswire/ -- AusperBio Therapeutics, Inc . and Ausper Biopharma Co., Ltd . (collectively AusperBio ), a privately held clinical-stage biotechnology company dedicated to advancing targeted oligonucleotide therapies to achieve a functional cure for chronic hepatitis B ( CHB ), today announced the successful completion of a USD 73 million Series B financing. The round was led by HanKang Capital , with participation from Sherpa Capital , CDH Investments , and a strategic investor, as well as continued participation from existing investors Qiming Venture Partners , InnoPinnacle Fund , and YuanBio Venture Capital . This financing followed the company's Series A round completed in July this year, demonstrating continued investor confidence in its proprietary platform and strategic direction. The proceeds will fund the continued Phase 2 development of AHB-137 , AusperBio's lead investigational therapy, supporting both clinical studies in China and global trials, as well as the development of commercial-scale manufacturing processes. The funding will also facilitate the expansion of the company's therapeutic pipeline and operational capabilities to drive sustained growth. Dr. Guofeng Cheng , co-founder and CEO of AusperBio, stated, " We are honored by our investors' confidence and support. This milestone financing recognizes our scientific and clinical accomplishments to date and enables us to accelerate our clinical programs and move closer to delivering a functional cure for CHB patients in need." Dr. Chris Yang , co-founder and CSO, added, "AHB-137 continues to attract attention from the scientific and clinical communities, particularly after the late-breaking oral presentation at the recent AASLD conference. The promising clinical data further validates our Med-OligoTM platform, strengthening our development of groundbreaking targeted oligonucleotide therapies for CHB and other serious chronic diseases." AusperBio is committed to delivering patient-centered innovations, aiming to alleviate the global health burden of CHB and transform treatment paradigms for this serious chronic disease. About AHB-137 AHB-137, a novel unconjugated antisense oligonucleotide ( ASO ) developed within AusperBio's proprietary Med-OligoTM ASO technology platform, was designed to treat chronic hepatitis B for a functional cure. Its compelling preclinical and Phase 1 clinical data were highlighted at the 2023 EASL conference and the 2024 EASL conference, respectively. Interim Phase 2a data was presented in a late-breaking oral session at the 2024 AASLD. This novel dual-mechanism ASO has completed its global Phase 1b trial and is now undergoing multiple Phase 2 trials in China . With its global development strategy, AHB-137 is advancing rapidly toward the goal of an HBV cure. About AusperBio. AusperBio is a clinical-stage biopharmaceutical company with operations in the USA and China , dedicated to advancing oligonucleotide and targeted delivery technologies for transformative therapies, with an initial focus on curing chronic hepatitis B infection. The company has developed a proprietary Med-OligoTM ASO platform which has been shown to substantially enhance the current ASO therapeutics, through novel insights into ASO design. Combining with efficient targeted delivery conjugation technologies, the modular Med-OligoTM Platform empowers ASO therapeutics to treat a broad range of diseases, including viral infections, metabolic conditions, genetic disorders, and immune diseases. For further information, please contact: Media Contact Email: info@ausperbio.com Investor Relations Contact: Tel: 650-888-1756 (US) Email: growth@ausperbio.com View original content to download multimedia: https://www.prnewswire.com/news-releases/ausperbio-secures-73-million-in-series-b-financing-to-advance-functional-cure-for-chronic-hepatitis-b-302339451.html SOURCE AusperBio Therapeutics Inc.CHICAGO — Seahawks starting running back Kenneth Walker III will miss the final two games of the regular season after the team announced Thursday it has placed him on injured reserve. The team made the announcement hours before its game Thursday night against the Bears in Chicago. Putting Walker on IR opened up a spot on the 53-man roster for rookie George Holani, who will become the third running back behind Zach Charbonnet and Kenny McIntosh. The news ends a disappointing third NFL season for Walker, who battled three different injuries and will end up rushing for just 573 yards in 11 games while averaging a career-low 3.7 yards per carry. The Seahawks also announced cornerback Artie Burns has been elevated off the practice squad to play against the Bears. Walker suffered an ankle injury in the fourth quarter of Sunday’s 27-23 loss to the Minnesota Vikings. Players who go on IR have to miss four games before they can return. That means Walker could return if Seattle were to get to the playoffs and then win two games. But it means he will miss a game next weekend against the Rams in Los Angeles that could have playoff implications. The team on Wednesday declared Walker out for Thursday’s game against the Bears. But coach Mike Macdonald had been vague about Walker’s status beyond that saying only “he’s gonna be out this game’’ when asked if the team had learned anything about a timeline for his return. Walker, who was the 41 st overall pick of the 2022 draft out of Michigan State, had 1,050 yards in 15 games as a rookie in 2022, averaging 4.6 per attempt. He followed that up with 905 yards in his second season in 2023, though he saw his yards-per-carry average drop to 4.1. The hope was Walker would rebound to his rookie numbers in 2024 under new offensive coordinator Ryan Grubb. The season started both promisingly and ominously. Walker rushed for 103 yards in a season-opening win over Denver. But he suffered an oblique injury in the game that caused him to sit out the next two weeks and foreshadowed an injury-filled season. Walker returned in week four but never again came close to the 100-yard mark for a game the rest of the season as Seattle struggled to get a running game going. His high total after the Denver game was 83 yards on 25 carries in a November home loss to the Rams. Walker then suffered a calf injury calf injury that held him out of games against Arizona and Green Bay earlier this month. He returned last week against the Vikings but had just 31 yards on eight carries before being sideline again. Walker also played a big role in the passing game this year with a career-high 46 receptions (he had 29 and 27 his first two years). But Walker gained just 299 yards on those catches with a long of 21 in a season when the injuries seemed to sap his explosiveness some. Walker, who had long gains of 74 yards in 2022 and 45 in 2023, had a long run this season of 28 in week four against the Lions. He didn’t have a run of longer than 14 in his last six games, encompassing 88 carries. The Seahawks will now go the rest of the way – barring a long playoff run --- with Charbonnet, a second-round pick in 2023 who has 453 yards and averaging 4.3 per attempt and turned in the best game this season by a Seahawk rusher with 134 in a in at Arizona on Dec. 8; and McIntosh, a seventh-round pick a year ago who has 77 on 17. Holani, an undrafted free agent out of Boise State, has 10 yards on three attempts. Grubb on Tuesday said he was confident the team can put together a good running game no matter who is in the backfield. "Yeah, I don't think that personnel-wise we should have any limitations,’’ he said. “We should be able to keep building those things up front. We're in good shape, so I think you just focus more on the offensive line and maybe less on the runners." Walker will enter the final season of his rookie contract in 2025 when he is due to make $1,856 million, none of which is guaranteed. Teams can extend rookie contracts after a player’s third year, meaning Walker could ask for a new deal following this season. Whether the Seahawks will want to --- or for how much --- could loom as one of the more intersestin questions of the off-season. This story will be updated.jb casino games



Key Manufacturing Logistics Market Trend: Advancing Logistics Through Digital Ecosystems And Sustainable TechnologiesTemple secures 60-42 win against HofstraUS agencies should use advanced technology to identify mysterious drones, Schumer says

CNBC Daily Open: Can quantum computing be used in the real world?One week into a new Syria, rebels aim for normalcy and Syrians vow not to be silent again DAMASCUS (AP) — A transformation has started to take place in the week since the unexpected overthrow of Syria’s President Bashar Assad. Suddenly in charge, the rebels have been met with a mix of excitement, grief and hope. And so far the transition has been surprisingly smooth. Reports of reprisals, revenge killings and sectarian violence are minimal, looting and destruction has been quickly contained. But there are a million ways it could go wrong. Syria is broken and isolated after five decades of Assad family rule. Families have been torn apart by war, former prisoners are traumatized, and tens of thousands of detainees remain missing. The economy is wrecked, poverty is widespread, inflation and unemployment are high. Corruption seeps through daily life. Christians in Syria mark country's transformation with tears as UN envoy urges an end to sanctions DAMASCUS, Syria (AP) — In churches across long-stifled Syria, Christians have marked the first Sunday services since Bashar Assad’s ouster in an air of transformation. Some were in tears, others clasped their hands in prayer. The U.N. envoy for Syria is calling for a quick end to Western sanctions as the country’s new leaders and regional and global powers discuss the way forward. The Syrian government has been under sanctions by the United States, the European Union and others for years as a result of Assad’s brutal response to what began as peaceful anti-government protests in 2011 and spiraled into civil war. Israel will close its Ireland embassy over Gaza tensions as Palestinian death toll nears 45,000 DEIR AL-BALAH, Gaza Strip (AP) — Israel says it will close its embassy in Ireland as relations deteriorate over the war in Gaza, where Palestinian medical officials say new Israeli airstrikes have killed over 30 people including children. Israel's decision to close the embassy came in response to what Israel’s foreign minister has described as Ireland's “extreme anti-Israel policies.” Ireland earlier announced that it would recognize a Palestinian state. And the Irish cabinet last week decided to formally intervene in South Africa’s case against Israel at the International Court of Justice, which accuses Israel of committing genocide in Gaza. The Palestinian death toll in the war is approaching 45,000. The GOP stoked fears of noncitizens voting. Cases in Ohio show how rhetoric and reality diverge AKRON, Ohio (AP) — Ohio's Republican secretary of state and attorney general sought to reassure voters before the November election that the state's elections were being vigorously protected against the possibility of immigrants voting illegally. That push coincided with a national Republican messaging strategy warning that potentially thousands of ineligible voters would be voting. The officials' efforts in Ohio led to charges against just six noncitizens in a state with 8 million registered voters. That outcome and the stories of some of those now facing charges show the gap both in Ohio and across the United States between the rhetoric about noncitizen voting and the reality that it's rare and not part of a coordinated scheme to throw elections. South Korean leaders seek calm after Yoon is impeached SEOUL, South Korea (AP) — South Korea’s opposition leader has offered to work with the government to ease the political tumult, a day after the opposition-controlled parliament voted to impeach conservative President Yoon Suk Yeol over a short-lived attempt to impose martial law. Liberal Democratic Party leader Lee Jae-myung, whose party holds a majority in the National Assembly, urged the Constitutional Court to rule swiftly on Yoon’s impeachment and proposed a special council for policy cooperation between the government and parliament. Yoon’s powers have been suspended until the court decides whether to remove him from office or reinstate him. If Yoon is dismissed, a national election to choose his successor must be held within 60 days. Storms across US bring heavy snow, dangerous ice and a tornado in California OMAHA, Neb. (AP) — Inclement weather has plagued areas of the U.S. in the first half of the weekend, with dangerous conditions including heavy snow, a major ice storm and unusual tornado activity. An ice storm beginning Friday created treacherous driving conditions across Iowa and eastern Nebraska. More than 33 inches of snow was reported near Orchard Park, New York, which is often a landing point for lake-effect snow. On Saturday, a tornado touched down in Scotts Valley, California, causing damage and several injuries. In San Francisco, a storm damaged trees and roofs and prompted a tornado warning, which was a first for a city that has not experienced a tornado since 2005. Small businesses say cautious shoppers are seeking 'cozy' and 'festive' this holiday season With a late Thanksgiving, the holiday shopping season is five days shorter than last year, and owners of small retail shops say that people have been quick to snap up holiday décor early, along with gifts for others and themselves. Cozy items like sweaters are popular so far. Businesses are also holding special events to get shoppers in the door. But there’s little sense of the freewheeling spending that occurred during the pandemic. Overall, The National Retail Federation predicts retail sales in November and December will rise between 2.5% and 3.5% compared with same period a year ago. US agencies should use advanced technology to identify mysterious drones, Schumer says After weeks of fear and bewilderment about the drones buzzing over parts of New York and New Jersey, U.S. Sen. Chuck Schumer is urging the federal government to deploy better drone-tracking technology to identify and ultimately stop the airborne pests. The New York Democrat is calling on the Department of Homeland Security to immediately deploy advanced technology to identify and track drones back to their landing spots. That is according to briefings from his office. Federal authorities have said that the drones do not appear to be linked to foreign governments. West Africa regional bloc approves exit timeline for 3 coup-hit member states ABUJA, Nigeria (AP) — West Africa’s regional bloc ECOWAS has approved an exit timeline for three coup-hit nations. It comes after a nearly yearlong process of mediation to avert the unprecedented disintegration of the grouping. The president of the ECOWAS Commission, Omar Touray, said in a statement: “The authority decides to set the period from 29 January, 2025 to 29 July 2025 as a transitional period and to keep ECOWAS doors open to the three countries during the transition period." In a first in the 15-nation bloc’s nearly 50 years of existence, the military juntas of Niger, Mali and Burkina Faso announced in January that they decided to leave ECOWAS. Pope Francis makes 1st papal visit to France's Corsica awash in expressions of popular piety AJACCIO, Corsica (AP) — Pope Francis on the first papal visit ever to the French island of Corsica on Sunday called for a dynamic form of laicism, promoting the kind of popular piety that distinguishes the Mediterranean island from secular France as a bridge between religious and civic society. The one-day visit to Corsica’s capital Ajaccio, birthplace of Napoleon, on Sunday is one of the briefest of his papacy beyond Italy’s borders, just about nine hours on the ground, including a 40-minute visit with French President Emmanuel Macron. It is the first papal visit ever to the island, which Genoa ceded to France in 1768 and is located closer to the Italian mainland than France.

Stock market today: Wall Street ends mixed after a bumpy week

ST JAMES, Jamaica — Minister of Tourism, Edmund Bartlett says the Caribbean region must not be left behind in taking advantage of artificial intelligence (AI) to propel the tourism sector forward. He said that as the global tourism landscape becomes increasingly competitive, more countries are recognising the potential of AI, and Jamaica and the wider Caribbean must utilise the technology to maintain the region’s competitive edge. Minister Bartlett, who was addressing a forum at the Sandals Royal Plantation in Ocho Rios, St Ann on Friday, noted that AI can become a pivotal tool in enhancing operational processes and creating more personalised experiences for travellers. “We are now seeing where many countries are not just using AI to streamline operations but also to enhance customer service. They have also been using the tool to analyse vast amounts of data to identify trends, preferences, and behaviours, enabling businesses to tailor their offerings to meet the specific needs of travellers. We can’t afford to be left behind,” he said. “We are at an exciting time in tourism history where, if leveraged correctly, we will be able to improve our processes and ultimately make more targeted and strategic decisions,” he added. Bartlett said the potential applications of AI in tourism are vast, ranging from automated customer service systems to advanced data analytics that inform marketing strategies. He said AI-powered chatbots can provide 24/7 assistance to travellers, answering queries and offering personalised recommendations. In addition, he noted that predictive analytics can help businesses anticipate traveller demand, allowing them to adjust pricing and availability accordingly. “The key lies in understanding the needs of the new landscape, which is increasingly driven by technology,” the minister pointed out. “From smart hotel rooms equipped with voice-activated controls to mobile apps that facilitate seamless check-ins, technology is fundamentally changing the way travellers interact with their destinations. In this context, Jamaica and the Caribbean must not only keep pace but also lead in the adoption of innovative solutions,” he said. The minister underscored the importance of training tourism workers to adapt to this new technological frontier. “This proactive approach to workforce training is crucial, as it empowers employees to utilise AI tools effectively, fostering an environment of innovation and adaptability,” he said. Noting that the integration of AI in tourism is not without its challenges, Bartlett said that concerns about job displacement and the digital divide must be addressed to ensure that the benefits of technology are equitably distributed. “While there is the relative fear of the unknown as it relates to technology, the world has been a better place, and mankind has benefited as a result of the advancement of technology,” he added. — JISAP News Summary at 2:00 p.m. EST

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8 Things to Remember About Dexter’s Childhood Before ‘Original Sin’One week into a new Syria, rebels aim for normalcy and Syrians vow not to be silent again DAMASCUS (AP) — A transformation has started to take place in the week since the unexpected overthrow of Syria’s President Bashar Assad. Suddenly in charge, the rebels have been met with a mix of excitement, grief and hope. And so far the transition has been surprisingly smooth. Reports of reprisals, revenge killings and sectarian violence are minimal, looting and destruction has been quickly contained. But there are a million ways it could go wrong. Syria is broken and isolated after five decades of Assad family rule. Families have been torn apart by war, former prisoners are traumatized, and tens of thousands of detainees remain missing. The economy is wrecked, poverty is widespread, inflation and unemployment are high. Corruption seeps through daily life. Christians in Syria mark country's transformation with tears as UN envoy urges an end to sanctions DAMASCUS, Syria (AP) — In churches across long-stifled Syria, Christians have marked the first Sunday services since Bashar Assad’s ouster in an air of transformation. Some were in tears, others clasped their hands in prayer. The U.N. envoy for Syria is calling for a quick end to Western sanctions as the country’s new leaders and regional and global powers discuss the way forward. The Syrian government has been under sanctions by the United States, the European Union and others for years as a result of Assad’s brutal response to what began as peaceful anti-government protests in 2011 and spiraled into civil war. Israel will close its Ireland embassy over Gaza tensions as Palestinian death toll nears 45,000 DEIR AL-BALAH, Gaza Strip (AP) — Israel says it will close its embassy in Ireland as relations deteriorate over the war in Gaza, where Palestinian medical officials say new Israeli airstrikes have killed over 30 people including children. Israel's decision to close the embassy came in response to what Israel’s foreign minister has described as Ireland's “extreme anti-Israel policies.” Ireland earlier announced that it would recognize a Palestinian state. And the Irish cabinet last week decided to formally intervene in South Africa’s case against Israel at the International Court of Justice, which accuses Israel of committing genocide in Gaza. The Palestinian death toll in the war is approaching 45,000. The GOP stoked fears of noncitizens voting. Cases in Ohio show how rhetoric and reality diverge AKRON, Ohio (AP) — Ohio's Republican secretary of state and attorney general sought to reassure voters before the November election that the state's elections were being vigorously protected against the possibility of immigrants voting illegally. That push coincided with a national Republican messaging strategy warning that potentially thousands of ineligible voters would be voting. The officials' efforts in Ohio led to charges against just six noncitizens in a state with 8 million registered voters. That outcome and the stories of some of those now facing charges show the gap both in Ohio and across the United States between the rhetoric about noncitizen voting and the reality that it's rare and not part of a coordinated scheme to throw elections. South Korean leaders seek calm after Yoon is impeached SEOUL, South Korea (AP) — South Korea’s opposition leader has offered to work with the government to ease the political tumult, a day after the opposition-controlled parliament voted to impeach conservative President Yoon Suk Yeol over a short-lived attempt to impose martial law. Liberal Democratic Party leader Lee Jae-myung, whose party holds a majority in the National Assembly, urged the Constitutional Court to rule swiftly on Yoon’s impeachment and proposed a special council for policy cooperation between the government and parliament. Yoon’s powers have been suspended until the court decides whether to remove him from office or reinstate him. If Yoon is dismissed, a national election to choose his successor must be held within 60 days. Storms across US bring heavy snow, dangerous ice and a tornado in California OMAHA, Neb. (AP) — Inclement weather has plagued areas of the U.S. in the first half of the weekend, with dangerous conditions including heavy snow, a major ice storm and unusual tornado activity. An ice storm beginning Friday created treacherous driving conditions across Iowa and eastern Nebraska. More than 33 inches of snow was reported near Orchard Park, New York, which is often a landing point for lake-effect snow. On Saturday, a tornado touched down in Scotts Valley, California, causing damage and several injuries. In San Francisco, a storm damaged trees and roofs and prompted a tornado warning, which was a first for a city that has not experienced a tornado since 2005. Small businesses say cautious shoppers are seeking 'cozy' and 'festive' this holiday season With a late Thanksgiving, the holiday shopping season is five days shorter than last year, and owners of small retail shops say that people have been quick to snap up holiday décor early, along with gifts for others and themselves. Cozy items like sweaters are popular so far. Businesses are also holding special events to get shoppers in the door. But there’s little sense of the freewheeling spending that occurred during the pandemic. Overall, The National Retail Federation predicts retail sales in November and December will rise between 2.5% and 3.5% compared with same period a year ago. US agencies should use advanced technology to identify mysterious drones, Schumer says After weeks of fear and bewilderment about the drones buzzing over parts of New York and New Jersey, U.S. Sen. Chuck Schumer is urging the federal government to deploy better drone-tracking technology to identify and ultimately stop the airborne pests. The New York Democrat is calling on the Department of Homeland Security to immediately deploy advanced technology to identify and track drones back to their landing spots. That is according to briefings from his office. Federal authorities have said that the drones do not appear to be linked to foreign governments. West Africa regional bloc approves exit timeline for 3 coup-hit member states ABUJA, Nigeria (AP) — West Africa’s regional bloc ECOWAS has approved an exit timeline for three coup-hit nations. It comes after a nearly yearlong process of mediation to avert the unprecedented disintegration of the grouping. The president of the ECOWAS Commission, Omar Touray, said in a statement: “The authority decides to set the period from 29 January, 2025 to 29 July 2025 as a transitional period and to keep ECOWAS doors open to the three countries during the transition period." In a first in the 15-nation bloc’s nearly 50 years of existence, the military juntas of Niger, Mali and Burkina Faso announced in January that they decided to leave ECOWAS. Pope Francis makes 1st papal visit to France's Corsica awash in expressions of popular piety AJACCIO, Corsica (AP) — Pope Francis on the first papal visit ever to the French island of Corsica on Sunday called for a dynamic form of laicism, promoting the kind of popular piety that distinguishes the Mediterranean island from secular France as a bridge between religious and civic society. The one-day visit to Corsica’s capital Ajaccio, birthplace of Napoleon, on Sunday is one of the briefest of his papacy beyond Italy’s borders, just about nine hours on the ground, including a 40-minute visit with French President Emmanuel Macron. It is the first papal visit ever to the island, which Genoa ceded to France in 1768 and is located closer to the Italian mainland than France.

WAYNE, PA — Guardian Capital Partners has acquired Team LINX, a Denver-based provider of technology infrastructure services, in partnership with the company’s executive management team, who will continue to lead the business. LINX specializes in designing, integrating, installing, and maintaining network, multimedia, wireless, and security systems for data centers and mission-critical applications. Founded in 2003, the company has delivered over 100,000 projects nationwide across a range of industries, including healthcare, financial services, and education, with a total value exceeding $1 billion. Scott Evans, Co-Founder and Managing Partner at Guardian, highlighted the strategic significance of the acquisition. “Our acquisition of LINX represents another compelling opportunity for Guardian to invest in a business that is well positioned to capitalize on the attractive digital infrastructure sector, which we believe continues to benefit from the secular trend of data proliferation and required capacity to fuel core services and advanced computing applications such as artificial intelligence,” Evans said. LINX’s leadership team sees the partnership with Guardian as a key step in accelerating growth and enhancing their offerings. Erik Isernhagen, President and CEO of LINX, expressed enthusiasm for the collaboration. “We are eager to embark on this next phase of our journey and view Guardian as the ideal partner to support our continued development. Not only does Guardian bring deep sector expertise, but our firms share a collaborative culture and strategic vision primed for delivering continued investment and powerful results for our stakeholders.” Jay Dzialo, COO of LINX, added, “Guardian’s operational playbook enables us to take our well-developed capabilities to the next level as we support our customers and teams at scale.” With Guardian’s investment and operational support, LINX aims to expand its reach within the technology infrastructure sector while meeting the growing demands of data-driven industries. Financing for the transaction was provided by MidCap Financial, with Goodwin Procter LLP and Arnold & Porter LLP serving as legal advisors to Guardian and LINX respectively. Industria Partners acted as strategic advisor to LINX. This acquisition positions LINX to capitalize on the ongoing expansion of digital infrastructure needs and reinforces Guardian’s commitment to investing in high-growth sectors. For the latest news on everything happening in Chester County and the surrounding area, be sure to follow MyChesCo on Google News and MSN .AP Trending SummaryBrief at 3:36 p.m. EST

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