SAN DIEGO , Nov. 21, 2024 /PRNewswire/ -- Avidity Biosciences, Inc. (Nasdaq: RNA), a biopharmaceutical company committed to delivering a new class of RNA therapeutics called Antibody Oligonucleotide Conjugates (AOCsTM), today announced that on November 20, 2024, the Human Capital Management Committee of Avidity's Board of Directors granted non-qualified stock option awards to purchase an aggregate of 117,000 shares of its common stock and 58,500 restricted stock units ("RSUs") to twelve (12) new non-executive employees under the Avidity Biosciences, Inc. 2022 Employment Inducement Incentive Award Plan (the "2022 Inducement Plan"). The awards were granted as inducements material to the employees entering into employment with Avidity in accordance with Nasdaq Listing Rule 5635(c)(4). The 2022 Inducement Plan is used exclusively for the grant of equity awards to individuals who were not previously employees of Avidity, or following a bona fide period of non-employment, as an inducement material to such individuals' entering into employment with Avidity, pursuant to Nasdaq Listing Rule 5635(c)(4). The options have an exercise price of $43.65 per share, which is equal to the closing price of Avidity's common stock on The Nasdaq Global Market on November 20, 2024, or the vesting commencement date. The shares subject to the stock options will vest over four years, with 25% of the shares vesting on the one-year anniversary of the vesting commencement date and the balance of the shares vesting in a series of 36 successive equal monthly installments thereafter, subject to each employee's continued employment with Avidity on such vesting dates. The RSUs will vest in four equal installments on the first four anniversaries of the vesting commencement date, subject to each employee's continued employment with Avidity on such vesting dates. The awards are subject to the terms and conditions of the 2022 Inducement Plan and the terms and conditions of a stock option agreement or RSU agreement, as applicable, covering the grant. About Avidity Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCsTM). Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare neuromuscular diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is also advancing two wholly-owned precision cardiology development candidates addressing rare genetic cardiomyopathies. In addition, Avidity is broadening the reach of AOCs with its advancing and expanding pipeline including programs in cardiology and immunology through key partnerships. Avidity is headquartered in San Diego, CA. For more information about our AOC platform, clinical development pipeline and people, please visit www.aviditybiosciences.com and engage with us on LinkedIn and X . Investor Contact: Mike MacLean (619) 837-5014 investors@aviditybio.com Media Contact: Navjot Rai (619) 837-5016 media@aviditybio.com View original content to download multimedia: https://www.prnewswire.com/news-releases/avidity-biosciences-announces-inducement-grants-under-nasdaq-listing-rule-5635c4-302313526.html SOURCE Avidity Biosciences, Inc.‘It’s pointless to continue’ – Andre Onana sensationally told to QUIT Man Utd by ex-star after nightmare errors
Deep-pocketed investors have adopted a bullish approach towards Estee Lauder Cos EL , and it's something market players shouldn't ignore. Our tracking of public options records at Benzinga unveiled this significant move today. The identity of these investors remains unknown, but such a substantial move in EL usually suggests something big is about to happen. We gleaned this information from our observations today when Benzinga's options scanner highlighted 10 extraordinary options activities for Estee Lauder Cos. This level of activity is out of the ordinary. The general mood among these heavyweight investors is divided, with 50% leaning bullish and 40% bearish. Among these notable options, 8 are puts, totaling $751,063, and 2 are calls, amounting to $57,539. Projected Price Targets After evaluating the trading volumes and Open Interest, it's evident that the major market movers are focusing on a price band between $79.0 and $145.0 for Estee Lauder Cos, spanning the last three months. Analyzing Volume & Open Interest In terms of liquidity and interest, the mean open interest for Estee Lauder Cos options trades today is 669.43 with a total volume of 666.00. In the following chart, we are able to follow the development of volume and open interest of call and put options for Estee Lauder Cos's big money trades within a strike price range of $79.0 to $145.0 over the last 30 days. Estee Lauder Cos 30-Day Option Volume & Interest Snapshot Noteworthy Options Activity: Symbol PUT/CALL Trade Type Sentiment Exp. Date Ask Bid Price Strike Price Total Trade Price Open Interest Volume EL PUT SWEEP BEARISH 09/19/25 $12.1 $11.8 $12.1 $80.00 $206.8K 72 175 EL PUT SWEEP BEARISH 10/17/25 $21.5 $21.2 $21.5 $95.00 $152.6K 173 74 EL PUT SWEEP BEARISH 10/17/25 $21.5 $21.2 $21.5 $95.00 $103.2K 173 122 EL PUT SWEEP BULLISH 01/16/26 $42.7 $42.2 $42.2 $120.00 $84.4K 1.6K 20 EL PUT SWEEP BULLISH 01/16/26 $42.6 $42.1 $42.1 $120.00 $67.3K 1.6K 21 About Estee Lauder Cos Estee Lauder is a leader in the global prestige beauty market, participating across skin care (51% of fiscal 2024 sales), makeup (29%), fragrance (16%), and hair care (4%) categories, with top-selling brands such as Estee Lauder, Clinique, M.A.C, La Mer, Jo Malone London, Aveda, Bobbi Brown, and Origins. The firm operates in more than 150 countries, generating 30% of revenue from the Americas, 39% from Europe, the Middle East and Africa (including travel retail), and 31% from Asia-Pacific. Estee Lauder sells its products through department stores, travel retail, specialty multibrand beauty stores, brand-dedicated freestanding stores, e-commerce, salons/spas, and perfumeries. Current Position of Estee Lauder Cos With a trading volume of 1,150,035, the price of EL is down by -1.46%, reaching $79.84. Current RSI values indicate that the stock is may be overbought. Next earnings report is scheduled for 53 days from now. What The Experts Say On Estee Lauder Cos In the last month, 1 experts released ratings on this stock with an average target price of $81.0. Turn $1000 into $1270 in just 20 days? 20-year pro options trader reveals his one-line chart technique that shows when to buy and sell. Copy his trades, which have had averaged a 27% profit every 20 days. Click here for access .* Consistent in their evaluation, an analyst from DA Davidson keeps a Buy rating on Estee Lauder Cos with a target price of $81. Options are a riskier asset compared to just trading the stock, but they have higher profit potential. Serious options traders manage this risk by educating themselves daily, scaling in and out of trades, following more than one indicator, and following the markets closely. If you want to stay updated on the latest options trades for Estee Lauder Cos, Benzinga Pro gives you real-time options trades alerts. © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.
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In the midst of this crisis, solidarity and compassion have emerged as beacons of hope. Volunteers and healthcare workers are working around the clock to provide support and comfort to the affected individuals and their families. The spirit of resilience and unity in the face of adversity is a testament to the strength and character of the Herb Valley community.
Aybar 2-5 8-11 12, Salatchoum 0-4 2-2 2, Brewer 8-11 1-4 18, Gittens 3-7 0-0 7, Jones 1-4 5-6 7, Williamson 2-7 0-0 5, Gray 1-6 0-0 2, Wilcox 0-2 0-0 0, K.Williams 2-3 0-0 6, Okeke 0-0 0-2 0, Grant 0-0 0-0 0. Totals 19-49 16-25 59. Guillouette 1-3 0-0 2, Barno 4-8 2-4 11, Johnson 3-9 0-0 9, McLean 7-12 2-2 18, Muniz 2-7 5-5 9, Duax 3-6 2-4 8, Stewart 1-6 0-0 3, Reddick 0-0 0-0 0, D.Williams 0-2 0-0 0, Washington 0-2 0-0 0. Totals 21-55 11-15 60. Halftime_FIU 30-29. 3-Point Goals_FIU 5-18 (K.Williams 2-3, Brewer 1-3, Williamson 1-3, Gittens 1-4, Aybar 0-2, Gray 0-3), Florida Gulf Coast 7-27 (Johnson 3-9, McLean 2-5, Barno 1-1, Stewart 1-6, Muniz 0-2, Washington 0-2, D.Williams 0-2). Fouled Out_McLean. Rebounds_FIU 33 (Brewer, Gittens 8), Florida Gulf Coast 29 (Muniz, Duax 8). Assists_FIU 8 (Aybar, Gittens 2), Florida Gulf Coast 13 (Barno, Muniz 5). Total Fouls_FIU 15, Florida Gulf Coast 21. A_1,601 (4,633).Thousands rally in Georgia to demand new elections
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Casey's: Fiscal Q2 Earnings SnapshotUCF and Tulsa will test their mettle against each other on Saturday afternoon in the Orange Bowl Basketball Classic in Sunrise, Fla. The Knights will make their first appearance in the event since recording a two-point loss to Missouri in 2022, while Tulsa's last trip to the Orange Bowl Classic was a loss to Florida State in 2012. UCF (7-2) may have something to prove being away from Addition Financial Arena. The Knights are 7-0 at home, whereas a November trip to the Greenbrier Tip-Off in West Virginia produced an 86-70 loss to Wisconsin and a triple-overtime setback against LSU. The Knights relied heavily on their defense in Sunday's 66-51 win over Tarleton State. After a sluggish start offensively, UCF found its rhythm during a 37-point second half. Jordan Ivy-Curry finished with a game-high 16 points and freshman center Moustapha Thiam collected 10 points, nine rebounds and six blocks. UCF's Big 12 opener draws closer (at Texas Tech, Dec. 31), but head coach Johnny Dawkins remains focused on daily improvement. "I feel a sense of urgency to get better, not with regards to Big 12 play to be quite frank, but every game," Dawkins said. "I don't look too far in the future. Pretty much I've always been in the moment as a player and as a person, and so for me it's about just getting better because it's our standards." Tulsa (4-6) looks to stop a three-game slide following a 70-66 home loss to Southern University last Saturday. Keaston Willis scored in double figures for the sixth time this season, netting a season-high 23 points off the bench. But Isaiah Barnes, one of three Golden Hurricane players to start all 10 games, was injured in the first half and played only eight minutes. To complicate matters, head coach Eric Konkol's team is 0-6 when trailing at halftime. "We got to get some guys healthy that can be healthy for next Saturday (against UCF)," Konkol said. "We got a couple other guys dealing with some different things, but then (also) having some planning to figure out what's the best way going forward for this group." --Field Level Media
BERLIN (AP) — Harry Kane scored a hat trick including two penalties for Bayern Munich to beat Augsburg 3-0 in the Bundesliga on Friday. The win stretched Bayern’s lead to eight points ahead of the rest of the 11th round, and Kane took his goals tally to a league-leading 14. The England forward is the fastest player to reach 50 goals in the Bundesliga in what was his 43rd game. However, coach Vincent Kompany should be concerned by his team’s ongoing difficulty of scoring in matches it dominates. Bayern previously defeated St. Pauli and Benfica only 1-0. Kompany’s team had to wait until stoppage time before Kane sealed the result with his second penalty. Two minutes later, Kane scored with a header after controlling Leon Goretzka's cross with his first touch for a flattering scoreline. “We had to be patient,” Kane said. “And at halftime that’s what we said, to keep doing what we’re doing. We had a few chances in the first half and we just had to be a bit more clinical and obviously, thankfully, we got the penalty to kind of open the game up.” Mads Pedersen was penalized for handball following a VAR review and Kane duly broke the deadlock in the 63rd. Bayern continued as before with 80% possession, but had to wait for Keven Schlotterbeck to be penalized through VAR for a foul on Kane. Kane sealed the result in the third minute of stoppage time and there was still time for him to grab another. It’s Bayern’s seventh consecutive win without conceding a goal since it conceded four at Barcelona (4-1) on Oct. 23 in the Champions League. “You can see now that we have a solid defense and that's the basis, also in games like today's,” Bayern midfielder Joshua Kimmich said. “When it's a game of patience, then it's important for us to know that sometimes one goal will have to do. Like today we added two more before the finish, but in the end you only need to score one more than the opponent.” Bayern next hosts Paris Saint-Germain in the Champions League on Tuesday, then Borussia Dortmund away in the Bundesliga next weekend, before defending champion Bayer Leverkusen visits in the third round of the German Cup. ___ AP soccer: https://apnews.com/hub/soccer Ciarán Fahey, The Associated Press
One dead in Ecuador, Peru ports closed amid massive waves
DALLAS (AP) — The championship vision that led Nathan Eovaldi to sign with Texas as a free agent two years ago is the same one that brought him back to the Rangers. Read this article for free: Already have an account? To continue reading, please subscribe: * DALLAS (AP) — The championship vision that led Nathan Eovaldi to sign with Texas as a free agent two years ago is the same one that brought him back to the Rangers. Read unlimited articles for free today: Already have an account? DALLAS (AP) — The championship vision that led Nathan Eovaldi to sign with Texas as a free agent two years ago is the same one that brought him back to the Rangers. A World Series title in his first season was followed by a losing record this year. “I believe in the guys in the group that we have. We were able to do it in ‘23. I don’t feel a lot has changed,” Eovaldi said Friday, a day after finalizing a $75 million, three-year contract. “We had a down year last year, but I’ve said it before, you learn a lot from losing seasons.” Eovaldi had declined a $20 million player option to become a free agent again and reaching an agreement during the winter meetings in Dallas. Texas also acquired slugging corner infielder Jake Burger in a swap with Miami. Burger had fallen asleep before getting a call late Tuesday night that he had been traded to Texas, where his family was already planning to move after the October birth of a daughter with Down syndrome. “The other city that is really good other than Nashville in terms of children’s hospital and resources for her Downs is in Dallas,” Burger said. “Not just from the baseball spectrum, from the life aspect as well ... I feel like it was meant to be, and we couldn’t be more more excited about that.” In the Nashville area, Burger lives close to Rangers manager Bruce Bochy, whom he plans to visit with soon. His former Marlins manager, Skip Schumaker, was hired last month by the Rangers as as a senior adviser for baseball operations, and Luis Urueta, Miami’s bench coach the past two seasons, recently joined Bochy’s on-field coaching staff for 2025. Burger and Rangers pitcher Dane Dunning were once roommates in the Chicago White Sox organization. Burger hit .250 with 29 home runs and 76 RBIs in 137 games for the Marlins last season, when he started 59 games at third base and 50 starts at first. He was with the White Sox in Texas when he got traded to Miami on Aug. 1, 2023, and four days later hit his first homer with the Marlins at Globe Life Field. When the Rangers made the title run in 2023, Eovaldi was 5-0 with a 2.95 ERA in six postseason starts. He was the winning pitcher in their World Series-clinching Game 5 at Arizona. He was also part of Boston’s 2018 title. Eovaldi was 12-8 this year with a 3.80 ERA in 29 starts, the last seven scoreless innings in the regular-season finale. He is 24-13 with a 3.72 ERA in 54 starts for Texas the past two seasons. Winnipeg Jets Game Days On Winnipeg Jets game days, hockey writers Mike McIntyre and Ken Wiebe send news, notes and quotes from the morning skate, as well as injury updates and lineup decisions. Arrives a few hours prior to puck drop. The new deal for the Texas native, who who turns 35 in February, includes a $12 million signing bonus, half payable on Nov. 15, 2026, and the rest on Jan. 15, 2028, and salaries of $18 million next season, $25 million in 2026 and $20 million in 2027. He gets a full no-trade provision. After being welcomed back by Chris Young, the Rangers president of baseball operations, the pitcher said he never felt like he really left. The Rangers stayed in contact throughout the process after he declined his option Nov. 4. “Kind of listening to the market and everything, I’m extremely happy to be back. I’m glad we were we were able to make it all work out,” Eovaldi said. “We had a lot of teams reach out right away and we were in contact with most them across the league. Ultimately we were able to make it back here.” ___ AP MLB: https://apnews.com/hub/mlb Advertisement AdvertisementUDUPI: Deputy Commissioner Vidya Kumari K has directed officials to implement necessary preventive measures to control Kyasanur Forest Disease (KFD), commonly known as Monkey Fever , which tends to occur between Nov and June. She stressed the importance of inter-departmental coordination to manage the situation effectively. Presiding over the coordination committee meeting held at the Rajathadri recently, the DC discussed the precautionary steps required to prevent KFD and other zoonotic diseases. IPL 2025 mega auction IPL Auction 2025 Live: Arshdeep Singh first player up for bids IPL Auction 2025: Who got whom IPL 2025 Auction: What is RTM card and how does Right to Match work? She noted that although KFD was observed in the Western Ghats and Malnad regions for years, there are currently no reported cases in the district. She explained that KFD usually arises when people venture into forests and encounter ticks carried by monkeys or livestock. To prevent this, she stressed the need to raise awareness among the public. Areas where dead monkeys are found will be marked as hotspots, and fever surveys will be conducted within a 2-kilometre radius. She also directed local health committees to hold awareness meetings and disseminate health information to both residents and tourists. Door-to-door awareness campaigns are to be conducted, particularly for communities living near forested areas, where the risk is higher. Symptoms of Monkey Fever include high fever lasting 3–5 days, severe body pain, red eyes, cough, and cold. Forest department staff were advised to report any sightings of dead monkeys to health authorities promptly and to take precautionary measures. Awareness campaigns should also be carried out using highway billboards. Further, Vidya Kumari noted an increase in dog bite cases in the district and instructed that all necessary measures be taken to control them. An adequate stock of vaccines for dog and snake bites should be maintained to ensure timely treatment. District Health and Family Welfare Officer Dr I.P. Gadad, District Surgeon Dr H. Ashok, District Surveillance Officer Dr Nagaratna, Malaria Control Officer Dr Prashanth Bhat, and others were present.
Panthers TE Ja'Tavion Sanders carted off field for neck injuryIn recent years, the cross-border e-commerce industry has been flourishing, providing opportunities for businesses to enter global markets and reach a wider audience. Recognizing the importance of fostering independent brands in this sector, Guangzhou, a prominent city in southern China, has initiated a series of roadshow events aimed at nurturing and promoting cross-border e-commerce independent brands.
BERLIN (AP) — Harry Kane scored a hat trick including two penalties for Bayern Munich to beat Augsburg 3-0 in the Bundesliga on Friday. The win stretched Bayern’s lead to eight points ahead of the rest of the 11th round, and Kane took his goals tally to a league-leading 14. The England forward is the fastest player to reach 50 goals in the Bundesliga in what was his 43rd game. However, coach Vincent Kompany should be concerned by his team’s ongoing difficulty of scoring in matches it dominates. Bayern previously defeated St. Pauli and Benfica only 1-0. Kompany’s team had to wait until stoppage time before Kane sealed the result with his second penalty. Two minutes later, Kane scored with a header after controlling Leon Goretzka's cross with his first touch for a flattering scoreline. “We had to be patient,” Kane said. “And at halftime that’s what we said, to keep doing what we’re doing. We had a few chances in the first half and we just had to be a bit more clinical and obviously, thankfully, we got the penalty to kind of open the game up.” Mads Pedersen was penalized for handball following a VAR review and Kane duly broke the deadlock in the 63rd. Bayern continued as before with 80% possession, but had to wait for Keven Schlotterbeck to be penalized through VAR for a foul on Kane. Kane sealed the result in the third minute of stoppage time and there was still time for him to grab another. It’s Bayern’s seventh consecutive win without conceding a goal since it conceded four at Barcelona (4-1) on Oct. 23 in the Champions League. “You can see now that we have a solid defense and that's the basis, also in games like today's,” Bayern midfielder Joshua Kimmich said. “When it's a game of patience, then it's important for us to know that sometimes one goal will have to do. Like today we added two more before the finish, but in the end you only need to score one more than the opponent.” Bayern next hosts Paris Saint-Germain in the Champions League on Tuesday, then Borussia Dortmund away in the Bundesliga next weekend, before defending champion Bayer Leverkusen visits in the third round of the German Cup. ___ AP soccer: https://apnews.com/hub/soccer Ciarán Fahey, The Associated PressMoving forward, it is crucial for Alibaba and other cloud service providers to remain vigilant and continually assess and update their security protocols to stay ahead of emerging threats. By investing in state-of-the-art technology and training personnel to respond effectively to emergencies, companies can safeguard against potential disruptions and uphold the trust of their users in an increasingly digital world.In conclusion, Huawei's impact on the Zhoushan Islands serves as a shining example of how technology can bridge divides and bring communities together. By focusing on service and innovation, Huawei has created a legacy of connectivity and warmth that will endure for generations to come. The islands of Zhoushan are not just connected by bridges of steel and concrete but by bridges of compassion, support, and progress. Huawei's commitment to building a better world through technology continues to inspire and uplift communities around the globe.