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Dazostinag sodium is under clinical development by and currently in Phase II for Oropharyngeal Cancer. According to GlobalData, Phase II drugs for Oropharyngeal Cancer have a 50% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Dazostinag sodium overview Dazostinag sodium (TAK-676) is under development for the treatment of advanced or metastatic solid tumors including non-small cell lung cancer, triple-negative breast cancer (TNBC), oropharyngeal cancer, colorectal cancer and head and neck cancer squamous cell carcinoma. The drug candidate is cyclic purine dinucleotide and acts by targeting stimulator of interferon genes (STING/TMEM173). It is a new molecular entity. It is administered via intravenous route. Takeda Pharmaceutical overview (Takeda) is a global pharmaceutical company primarily engaged in the research, development, production, and commercialization of biopharmaceutical products. It provides treatment for inflammatory bowel disease, acid-related diseases, motility disorders and liver diseases; hemophilia and hereditary bleeding disorders; primary immunodeficiency and multifocal motor neuropathy; major depressive disorder and attention-deficit hyperactivity disorder; and its cancer treatment encompasses multiple myeloma, mantle cell lymphoma, non-small cell lung cancer and chronic myeloid leukemia. While the company markets its pharmaceutical products directly, it also collaborates with marketing alliance partners in worldwide. Takeda operates in various countries worldwide, including Japan, the US, Europe, Latin America, Africa, the Middle East, and the Asia Pacific region. Takeda is headquartered in Tokyo, Japan. For a complete picture of Dazostinag sodium’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .

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Tobi Egberongbe is stealing a few moments away from the launch of his brand’s latest physical retail space in Atlanta when we catch up over a video call. The founder behind who is a bit lowkey has been toiling away as of late on a pop-up located inside Ponce City Market. The semi-permanent location that launched last weekend is a product of Egberongbe’s diligence and also his of a brand he launched while he attended many moons ago. Officially launching in 2011, Mifland has risen in the athleisure and spaces–it sticks out because it’s one of a few Black-owned brands that have built a robust following and is still running. Alongside the retail space, the multi-hyphenate tells me he’s for the of his new collaboration between Mifland and the Atlanta Falcons. “I think today a lot of the time you see two brands smack logos together and call it a collaboration,” Egberongbe shares. The capsule is the opposite of that. The designer tells me that he worked alongside the Atlanta Falcons’ senior creative director Larry Luke someone he’d previously known for years to bring the capsule to life. Many variations of designs ensued. But what they managed to come up with isn’t corny, instead, it’s a solid lineup of clothing that doesn’t try too hard. While logos were used Egberongbe says there was a major emphasis on what super fans of the NFL would wear–while additional emphasis was placed on the fandom surrounding the team. What eventually came into fruition after months of planning and scrapped designs fits in with the looming trend of tunnel outfits: a sleek and wearable , a vintage-inspired tracksuit, a hooded sweatshirt, and a tee. A quilted red and black jacket rounds out the capsule. The tracksuit is a surefire standout to me largely because it harkens back to the era when padded shoulders were in. Egberongbe says the cream and red outfit was inspired by former NFL player and legend . Before all the fanfare surrounding tunnel outfits Sanders keyed in on personal style in a unique manner. It’s fitting that this ensemble features a callback to him and his impressive fashion moments. Design codes that stayed true to Mifland were an important part of the process. When I tasked Tobi with divulging how he stayed true to this notion he said the cardigan is an example of this. This piece features the Mifland “M” logo emblazoned throughout–but the bright red hue pinpoints the red that is proudly worn at the team’s Mercedes-Benz Stadium (the collection is also available there). “The cardigan is one of my favorite things,” Tobi shared. “If I went to a game and [wore] that, and it’s just [about] being the most comfortable I could be, and it’s still fashionable too.” Messaging rings clearly throughout the collection. If you look intently you’ll notice that each item has distinct detailing. Further proving that the capsule wasn’t created for the sake of creation. “Visually, we wanted this collection to feel unexpected–a different offering than what you might normally see from a sports team, and a true representation of the creative culture in Atlanta,” shared Larry Luke, senior creative director of the Atlanta Falcons. He also added that you can read about the lauded city all you want but experiencing it is a different story. Luke expressed that the two respective companies also wanted the design to reflect a perfect synergy between the team and Mifland. By doing so he is hopeful it will resonate equally with both audiences while maintaining the integrity of each brand’s identity. With tunnel fashion looming in the peripheral Mifland and the Atlanta Falcons leaned on Ray Ray McLeod II for the capsule’s campaign. Aside from his prowess on the field ahead of each game the Atlanta Falcons wide receiver regularly keeps many of us on our toes. No matter what he’s aiming for he strikes a cord especially when donning bold trousers or oversized outerwear. “The goal was to strike a balance—designs that feel authentically Falcons and unmistakably Mifland. This even split allows us to engage fans who appreciate high-end streetwear and craftsmanship while celebrating the shared values of quality and creativity,” Luke added. To shop the Mifland X Atlanta Falcons capsule collection head to . You can also shop the collection at the Mercedes-Benz Stadium. Pricing starts at $68.Fossilized footprints reveal 2 extinct hominin species living side by side 1.5 million years ago

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Hologic Inc. stock rises Friday, still underperforms marketYouTube star IShowSpeed has responded after NFL wide receiver Tyreek Hill offered to race the streamer for $100K, barring one specific condition. On November 30, Hill went live on Twitch to play some Fortnite when he brought up Speed’s viral $100K footrace against Olympic sprinter Noah Lyles , saying that he should be given the “same chance” to compete with the streamer. He challenged Speed to a race for the same amount of money — but only if the YouTuber donates to his charity, the Tyreek Hill Family Foundation , a nonprofit organization that helps at-risk youth through health and wellness programs. IShowSpeed wants to race Tyreek Hill in $100K charity wager After this news spread on social media, Speed offered his rebuttal, saying he’s more than willing to step up to Hill’s challenge and donate to his charity. However, he claims that Hill has been ducking him, saying he pulled up to one of his practices and was rebuffed. “Tyreek Hill, you’re about 20-30 minutes away [from me]. I’m tired of hearing your sh*t. I pulled up to your practice last time. You didn’t wanna race me ’cause you were scared. “This is what we gon’ do. Let’s play by your rules. Let’s do $100K race, 40-yard sprint, whenever. Let’s stop the bullsh*t. You are 20 minutes away, and I will donate to your foundation or charity. Let’s race $100K for charity, in fact. “So if I win, you donate to whatever charity that I want to, or you give it to one of my supporters. Tyreek Hill, all you do is talk, bro. That’s all you do.” Related: 🚨| BREAKING: Speed called out @cheetah for a $100,000 40m race! 🤯 pic.twitter.com/4sepMfcrno At the time of writing, Hill has not responded to Speed’s rebuttal, leaving fans anxious to see if these two will eventually face off on the track. Hill is just the latest athlete to feature in Speed’s streams, following his broadcast with Lyles, renowned boxer Manny Pacquiao , and even Olympic gymnast Frederick ‘Flips’ Richard.Jimmy Carter was the epitome of a servant leader, said Rocky Face resident George Sutherland. "It was never about him," said Sutherland. "It was about what was best for the community, for the state, for the nation." Carter, a former president and governor of Georgia, passed away in Plains on Sunday about 3:45 p.m. at age 100. Carter had been in hospice care since February 2023. Sutherland grew up in Plains and knew Carter since Sutherland was a boy. Carter returned to Plains in 1953, leaving the U.S. Navy to take over the family peanut farm and warehouse after the death of his father. "He was a very personable individual," Sutherland said. "My dad was a peanut farmer like the Carters. He'd do business with the Carter warehouse. I remember being there. He was very hands on. I remember siting on a sawhorse while he was building something and talking to him. I was probably 10 or 11 years old. He was very easy to talk to." Sutherland recalls that Carter quickly became a leader in the community. In 1957, Carter served as the president of the Plains Lions Club, and under his leadership, the club built and began to operate a community swimming pool. "That's one of the first things I remember him doing," Sutherland said. "He also organized a group of businessmen to recruit a doctor when the only doctor in Plains retired." Dalton attorney Terry Miller first got to know Carter while working as an intern in the governor's office during Carter's tenure. He would later have some interaction with Carter while working for U.S. Rep. Ed Jenkins during Carter's term as president. "I attended Emory University in Atlanta from 1968 to 1972, and some of my college days overlapped with his service in the governor's mansion (1971 to 1975)," Miller said. "While I was in school, I believe it was his administration that initiated the governor's intern program. The summer after my third year of college, I applied for and was accepted by that program with a number of other college students from around the state. I was assigned that summer and the next summer, because I did it for two summers, the State Board of Pardons and Paroles." Miller described the internship as a tremendous learning experience. "The governor's key people would hold seminars for us about state government," he said. "It was an interesting time." He said he didn't have a great deal of interaction with Carter, but the time he did spend with him left a big impression on him. "I, and I believe that most if not all of the other students in the intern program, felt that both Rosalynn and Jimmy Carter were interested in us," he said. "I think that was the reason he organized that opportunity for students. The two of them would organize a reception at least once a month for the students at the governor's mansion. They were gracious hosts, very kind." "The people who worked for him in the governor's office, many of whom went with him to Washington, were very loyal to him," Miller said. "And he was definitely a man of faith." Miller said there was a sense of urgency in the governor's office. "The thing I remember is that governors were limited to one term in those days," he said. "The window of opportunity to get things done was really the first two years. A lot of times, their ability to get things done in their final year, maybe final two years, was limited because people in the legislature knew they weren't going to be there much longer." Miller said Jenkins told him "there probably wasn't a finer person in public service." "That was one of the impressions I had, too" Miller said. "Of course, I didn't have a lot of interaction with him personally, but I did interact with members of his administration, both in Atlanta and Washington, and I enjoyed being around them. Something that Mr. Jenkins and I talked about often was that whether you agreed with Carter on an issue or disagreed, you felt that he had an honorable intention behind his position." Miller said Carter was a student of the Middle East, probably because of his strong faith. "He had an enormous heart for peace in the Middle East. I think that's why he was able to get (Egyptian president Anwar) Sadat and (Israeli prime minister Menachem) Begin together to reach that accord." "I believe that his reputation will only increase as we look back through the years," Miller said. Dalton State College professor Ken Ellinger was 17 when Carter first ran for president in 1976. "It was the first political campaign I was personally involved in," he said. "My dad sponsored the Young Democrats at Southwestern Oklahoma State University. I went door-to-door with the Young Democrats campaigning for Carter. All of those young college kids were extremely fired-up about Jimmy Carter." Ellinger said Carter's sincerity appealed to that generation. "It seems hokey today because there is so much cynicism today," he said. "But he was such a breath of fresh air coming out of Watergate, so forthright, so earnest. He answered hard questions, and he gave thoughtful answers." Seventeen candidates sought the Democratic presidential nomination that year, and several started the race with greater name recognition than the one-term governor of Georgia. "When he started out he was such a dark horse," Ellinger said. "People were saying 'Jimmy who?'" Ellinger said he takes issue with those who say Carter had a failed presidency, pointing to accomplishments such as the Middle East peace deal between Egypt and Israel and the treaties that gave Panama control of the Panama Canal. "I think he was committed to doing the right thing even if it wasn't the popular thing," he said. Ellinger pointed to the unconditional pardon Carter granted to those who evaded the draft during the Vietnam War. "I'm sure he knew that would hurt him politically but it was the right thing to do," he said. After leaving office in 1981, Carter remained active in world affairs through the Carter Center in Atlanta, but he continued to call Plains home. "I think it's neat that he came back to Plains and never gave up his house," Ellinger said. In 2003, Ellinger and his family traveled to Plains and took part in a Sunday School class Carter conducted at Maranatha Baptist Church. "He was an excellent Sunday School teacher," he recalled. "My daughter, who was 16 at the time, said it was the best Sunday School lesson she'd ever heard. He related the Bible to things going on in the world." Dalton attorney Warren Coppedge and his wife Patti were among the volunteers on Carter's 1971 run for governor. "As was typical of the day, a candidate would visit the Oakwood Cafe at meal time, walk in the front door and shake hands with customers," Warren Coppedge recalled in a written account. "Jimmy Carter visited the Oakwood, but he entered through the kitchen and shook hands with the employees first." Coppedge was later part of the Peanut Brigade, a group of volunteers, mostly from Georgia, who campaigned across the country for Carter during his 1976 presidential run.

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